Evidence map›Paper›PMID 36132078›Full record

ArticleBioMed research international2022

Nanocurcumin Improves Lipid Status, Oxidative Stress, and Function of the Liver in Aluminium Phosphide-Induced Toxicity: Cellular and Molecular Mechanisms.

Ali Salimi, Nejat Kheiripour, Ali Fathi Jouzdani, Hassan Ghasemi, Sara Soleimani Asl, Abolfazl Ghafouri-Khosrowshahi, Akram Ranjbar

Open access · hybridAbstract read
In one paragraph

Article in BioMed research international, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers.

0numbers the graph read from it
0cells of the map it votes in
10citing papers in PubMed
1.0field-weighted citation impact, top 27% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

10 citing papers in PubMed, 16 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 2 institutions in 1 country.

Ali SalimiMedicinal Plants and Natural Products Research Center, Hamadan University of Medical Sciences, Hamadan, Iran.
Nejat KheiripourResearch Center for Biochemistry and Nutrition in Metabolic Diseases, Kashan University of Medical Sciences, Kashan, Iran.ORCID https://orcid.org/0000-0003-0684-7125
Ali Fathi JouzdaniStudent Research Committee, Hamadan University of Medical Science, Hamadan, Iran.ORCID https://orcid.org/0000-0002-6838-929X
Hassan GhasemiDepartment of Clinical Biochemistry, Abadan School of Medical Sciences, Abadan, Iran.ORCID https://orcid.org/0000-0001-7809-2732
Sara Soleimani AslDepartment of Anatomical Sciences, Faculty of Medicine, Hamadan University of Medical Sciences, Hamadan, Iran.ORCID https://orcid.org/0000-0003-1518-3308
Abolfazl Ghafouri-KhosrowshahiDepartments of Medicinal Chemistry and Pharmacology and Toxicology, School of Pharmacy, Hamadan University of Medical Sciences, Hamadan, Iran.ORCID https://orcid.org/0000-0002-6054-9682
Akram RanjbarMedicinal Plants and Natural Products Research Center, Hamadan University of Medical Sciences, Hamadan, Iran.ORCID https://orcid.org/0000-0002-4564-3603
Hamedan University of Medical Sciences · IRKashan University of Medical Sciences · IR

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Background: The present study aimed to evaluate the effect of nanocurcumin and curcumin on liver transaminases, lipid profile, oxidant and antioxidant system, and pathophysiological changes in aluminium phosphide (ALP) induced hepatoxicity. Results: In the aluminium phosphide group, there was a significant increase in MDA, ALT, AST, and AP and total bilirubin, cholesterol, triglyceride, LDL, and VLDL; AST, ALT, total bilirubin, LDL, VLDL, cholesterol, and MDA were significantly decreased; and HDL and TAC were significantly increased compared to ALP ( Conclusion: Nanocurcumin significantly protects the liver against aluminum phosphide toxicity. It is suggested that nanocurcumin-based drugs be developed to reduce the toxic effects of ALP in poisoned patients.

Indexed as

AntioxidantsCurcuminAlanine TransaminaseAlkaline PhosphataseAluminum CompoundsAnimalsAspartate AminotransferasesBilirubinCatalaseCholesterol, LDLEosine Yellowish-(YS)Forkhead Box Protein O1Glutathione PeroxidaseHematoxylinLipoproteins, HDLLipoproteins, VLDLAlanine TransaminaseAlkaline PhosphataseAluminum Compoundsaluminum phosphideAntioxidantsAspartate AminotransferasesBilirubinCatalaseCholesterol, LDLCurcuminEosine Yellowish-(YS)Forkhead Box Protein O1Glutathione PeroxidaseHematoxylinLipoproteins, HDLLipoproteins, VLDLMalondialdehydeOxidantsPhosphinesRNA, MessengerSirtuin 1Triglycerides

Identifiers

PMID36132078
PMCPMC9484886
OpenAlexW4295880772

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.