Evidence map›Paper›PMID 36132026›Full record

ArticleNanoscale advances2020

Boosting nanotoxicity to combat multidrug-resistant bacteria in pathophysiological environments.

Dana Westmeier, Svenja Siemer, Cecilia Vallet, Jörg Steinmann, Dominic Docter, Jan Buer, Shirley K Knauer, Roland H Stauber

Abstract read
In one paragraph

Article in Nanoscale advances, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

5 citing papers in PubMed.

  1. Article
  2. Review
  3. Article
  4. Article
  5. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Dana WestmeierENT Department, University Medical Center Mainz Langenbeckstrasse 1 55131 Mainz Germany rstauber@uni-mainz.de.ORCID https://orcid.org/0000-0003-3929-1231
Svenja SiemerENT Department, University Medical Center Mainz Langenbeckstrasse 1 55131 Mainz Germany rstauber@uni-mainz.de.
Cecilia ValletDepartment of Molecular Biology II, Center for Medical Biotechnology/Nanointegration (ZMB/CENIDE), University Duisburg-Essen, Universitätsstrasse 5 45117 Essen Germany.
Jörg SteinmannInstitute of Medical Microbiology, University Hospital Essen, University Duisburg-Essen Hufelandstrasse 55 45112 Essen Germany.
Dominic DocterENT Department, University Medical Center Mainz Langenbeckstrasse 1 55131 Mainz Germany rstauber@uni-mainz.de.
Jan BuerInstitute of Medical Microbiology, University Hospital Essen, University Duisburg-Essen Hufelandstrasse 55 45112 Essen Germany.
Shirley K KnauerDepartment of Molecular Biology II, Center for Medical Biotechnology/Nanointegration (ZMB/CENIDE), University Duisburg-Essen, Universitätsstrasse 5 45117 Essen Germany.ORCID https://orcid.org/0000-0003-4321-0924
Roland H StauberENT Department, University Medical Center Mainz Langenbeckstrasse 1 55131 Mainz Germany rstauber@uni-mainz.de.ORCID https://orcid.org/0000-0002-1341-4523

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Nanomaterials are promising novel antibiotics, but often ineffective. We found that nanomaterial-bacteria complex formation occurred with various nanomaterials. The bactericidal activity of NMs strongly depends on their physical binding to (multidrug-resistant) bacteria. Nanomaterials' binding and antibiotic effect was reduced by various pathophysiological biomolecule coronas strongly inhibiting their antibiotic effects. We show from analytical to

Identifiers

PMID36132026
PMCPMC9419095

What OpenQuestion holds

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LicenceCC BY-NC
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.