Evidence map›Paper›PMID 36131938›Full record

ArticleFrontiers in immunology2022

Specific transcriptional programs differentiate ICOS from CD28 costimulatory signaling in human Naïve CD4

Casimiro Luca Gigliotti, Elena Boggio, Francesco Favero, Danny Incarnato, Claudio Santoro, Salvatore Oliviero, Josè Maria Rojo, Silvia Zucchelli, Francesca Persichetti, Gianluca Baldanzi and 2 more

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Frontiers in immunology, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
0.4field-weighted citation impact, top 42% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed, 6 citations in OpenAlex.

  1. Review
  2. Review
  3. Article
  4. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors at 4 institutions in 3 countries.

Casimiro Luca GigliottiDepartment of Health Sciences, University of Piemonte Orientale, Novara, Italy.
Elena BoggioDepartment of Health Sciences, University of Piemonte Orientale, Novara, Italy.
Francesco FaveroDepartment of Health Sciences, University of Piemonte Orientale, Novara, Italy.
Danny IncarnatoDepartment of Molecular Genetics, Groningen Biomolecular Sciences and Biotechnology Institute (GBB), University of Groningen, Groningen, Netherlands.
Claudio SantoroDepartment of Health Sciences, University of Piemonte Orientale, Novara, Italy.
Salvatore OlivieroDipartimento di Scienze della Vita e Biologia dei Sistemi, Università di Torino, Torino, Italy.
Josè Maria RojoCentro de Investigaciones Biológicas Margarita Salas, Consejo Superior de Investigaciones Cientificas (CSIC), Madrid, Spain.
Silvia ZucchelliDepartment of Health Sciences, University of Piemonte Orientale, Novara, Italy.
Francesca PersichettiDepartment of Health Sciences, University of Piemonte Orientale, Novara, Italy.
Gianluca BaldanziInterdisciplinary Research Center of Autoimmune Diseases (IRCAD), University of Piemonte Orientale, Novara, Italy.
Umberto DianzaniDepartment of Health Sciences, University of Piemonte Orientale, Novara, Italy.
Davide CoràInterdisciplinary Research Center of Autoimmune Diseases (IRCAD), University of Piemonte Orientale, Novara, Italy.
Università degli Studi del Piemonte Orientale “Amedeo Avogadro” · ITCentro de Investigaciones Biológicas Margarita Salas · ESUniversity of Groningen · NLUniversity of Turin · IT

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Costimulatory molecules of the CD28 family play a crucial role in the activation of immune responses in T lymphocytes, complementing and modulating signals originating from the T-cell receptor (TCR) complex. Although distinct functional roles have been demonstrated for each family member, the specific signaling pathways differentiating ICOS- from CD28-mediated costimulation during early T-cell activation are poorly characterized. In the present study, we have performed RNA-Seq-based global transcriptome profiling of anti-CD3-treated naïve CD4

Indexed as

CD28 AntigensCD4-Positive T-LymphocytesCholesterolGlycosaminoglycansHumansInducible T-Cell Co-Stimulator Proteinp38 Mitogen-Activated Protein KinasesReceptors, Antigen, T-CellTranscription, GeneticCD28 AntigensCholesterolGlycosaminoglycansICOS protein, humanInducible T-Cell Co-Stimulator Proteinp38 Mitogen-Activated Protein KinasesReceptors, Antigen, T-CellCD28human CD4+ T cellsICOSRNA sequencingT-cell receptor

Identifiers

PMID36131938
PMCPMC9484324
OpenAlexW4294680027

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.