ArticleFrontiers in immunology2022
Decoding human-macaque interspecies differences in Fc-effector functions: The structural basis for CD16-dependent effector function in Rhesus macaques.
Open access · goldAbstract read
In one paragraph
Article in Frontiers in immunology, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers.
0numbers the graph read from it
0cells of the map it votes in
16citing papers in PubMed
2.7field-weighted citation impact, top 10% of its field
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
16 citing papers in PubMed, 20 citations in OpenAlex.
- A chikungunya virus-like particle vaccine reduces chikungunya disease in cynomolgus macaques and protection is mediated by antibody transferred from vaccinated humans.NPJ vaccines · 2026Article
- The impact of N-glycan conformational entropy on the binding affinity of Fc γ receptor IIIa/CD16a.Structure (London, England : 1993) · 2026Article
- A chikungunya virus-like particle vaccine reduces chikungunya disease in cynomolgus macaques and protection is mediated by antibody transferred from vaccinated humans.Research square · 2025Article
- Identifying correlates of viral rebound timing and viral control in SHIV-infected infant macaques after ART interruption.Science translational medicine · 2025Article
- Patterns and functional consequences of antibody speciation in maternal-fetal transfer of coronavirus-specific humoral immunity.PLoS pathogens · 2025Article
- Cross-species analysis of FcγRIIa/b (CD32a/b) polymorphisms at position 131: structural and functional insights into the mechanism of IgG- mediated phagocytosis in human and macaque.Frontiers in immunology · 2025Article
- Article
- One N-glycan regulates natural killer cell antibody-dependent cell-mediated cytotoxicity and modulates Fc γ receptor IIIa / CD16a structure.bioRxiv : the preprint server for biology · 2024Article
- Identification of the Linear Fc-Binding Site on the Bovine IgG1 Fc Receptor (boFcγRIII) Using Synthetic Peptides.Veterinary sciences · 2024Article
- Macrophage N-glycan processing inhibits antibody-dependent cellular phagocytosis.Glycobiology · 2023Article
- Conjugation of HIV-1 envelope to hepatitis B surface antigen alters vaccine responses in rhesus macaques.NPJ vaccines · 2023Article
- Relationship of maternal cytomegalovirus-specific antibody responses and viral load to vertical transmission risk following primary maternal infection in a rhesus macaque model.PLoS pathogens · 2023Article
- IgG Fc-Binding Peptide-Conjugated Pan-CoV Fusion Inhibitor Exhibits Extended In Vivo Half-Life and Synergistic Antiviral Effect When Combined with Neutralizing Antibodies.Biomolecules · 2023Article
- Relationship of maternal cytomegalovirus-specific antibody responses and viral load to vertical transmission risk following primary maternal infection in a rhesus macaque model.bioRxiv : the preprint server for biology · 2023Article
- Multivariate analysis of FcR-mediated NK cell functions identifies unique clustering among humans and rhesus macaques.Frontiers in immunology · 2023Article
- Defining genetic diversity of rhesus macaque Fcγ receptors with long-read RNA sequencing.Frontiers in immunology · 2023Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
13 authors at 6 institutions in 2 countries.
William D TolbertInfectious Disease Division, Department of Medicine, Uniformed Services University of the Health Sciences, Bethesda, MD, United States.
Neelakshi GohainInstitute of Human Virology, University of Maryland School of Medicine, Baltimore, MD, United States.
Paul G KremerDepartment of Biochemistry and Molecular Biology, University of Georgia, Athens, GA, United States.
Andrew P HedermanThayer School of Engineering, Dartmouth College, Hanover, NH, United States.
Dung N NguyenInfectious Disease Division, Department of Medicine, Uniformed Services University of the Health Sciences, Bethesda, MD, United States.
Verna VanInstitute of Human Virology, University of Maryland School of Medicine, Baltimore, MD, United States.
Rebekah SherburnInfectious Disease Division, Department of Medicine, Uniformed Services University of the Health Sciences, Bethesda, MD, United States.
George K LewisInstitute of Human Virology, University of Maryland School of Medicine, Baltimore, MD, United States.
Andrés FinziCentre de recherche du CHUM, Montreal, QC, Canada.
Justin PollaraDepartment of Surgery, Duke University School of Medicine, Durham, NC, United States.
Margaret E AckermanThayer School of Engineering, Dartmouth College, Hanover, NH, United States.
Adam W BarbDepartment of Biochemistry and Molecular Biology, University of Georgia, Athens, GA, United States.
Marzena PazgierInfectious Disease Division, Department of Medicine, Uniformed Services University of the Health Sciences, Bethesda, MD, United States.
Uniformed Services University of the Health Sciences · USUniversity of Maryland, Baltimore · USDartmouth College · USUniversity of Georgia · USDuke University · USUniversité de Montréal · CA
Funding
Structure-Function Analytics CoreP01AI162242 · NIAID · DUKE UNIVERSITY · PI TOMARAS, GEORGIA DORIS · 2021 to 2025
$22.2MPhysical Resources CoreP01AI120756 · NIAID · DUKE UNIVERSITY · PI TOMARAS, GEORGIA DORIS · 2016 to 2020
$17.1MProject 3- Mucosal Determinants of Virus TransmissionP01AI124912 · NIAID · UNIVERSITY OF MARYLAND BALTIMORE · PI GALLO, ROBERT C · 2016 to 2019
$14.4MUnlocking Envelope: A New Strategy for a Functional Cure Through Antibody-Dependent Cell-Mediated CytotoxicityR01AI129769 · NIAID · UNIVERSITY OF MARYLAND BALTIMORE · PI PAZGIER, MARZENA ELZBIETA · 2017 to 2021
$2.3MComposition and structure of antibody receptors at the surface of primary human cells during immune activationU01AI148114 · NIAID · UNIVERSITY OF GEORGIA · PI BARB, ADAM WESLEY, MACE, EMILY MARGARET · 2020 to 2024
$2.0MStructural Targeting of Potentially Protective gp120 Epitopes in the C1/C2 RegionR01AI116274 · NIAID · UNIVERSITY OF MARYLAND BALTIMORE · PI PAZGIER, MARZENA ELZBIETA · 2016 to 2019
$1.5MNIAID NIH HHS P01 AI120756NIAID NIH HHS P01 AI124912NIAID NIH HHS P01 AI162242NIAID NIH HHS R01 AI116274NIAID NIH HHS R01 AI129769NIAID NIH HHS U01 AI148114
Abstract
Fc mediated effector functions of antibodies play important roles in immunotherapies and vaccine efficacy but assessing those functions in animal models can be challenging due to species differences. Rhesus macaques,
Indexed as
Immunoglobulin GPolysaccharidesAnimalsHumansImmunoglobulin Fc FragmentsMacaca mulattaReceptors, IgGImmunoglobulin Fc FragmentsImmunoglobulin GPolysaccharidesReceptors, IgGCD16Fc-effector functionFcγRIII Val/Ile158IgG1(Fc)- FcγRIII complex structure - function of RM FcγRIII Ile/Val 158Rhesus macaques Macaca mulatta
Identifiers
What OpenQuestion holds
Textmetadata
LicenceCC BY
Read underepoch 390
Registered trials
None linked
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.