ArticleBMC ophthalmology2022
Systemic immune-inflammation index could be associated with pseudophakic cystoid macular edema after an uneventful phacoemulsification surgery in patients without risk factors.
Article in BMC ophthalmology, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers.
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11 citing papers in PubMed, 12 citations in OpenAlex.
- Earlier onset of type 2 diabetes mellitus as a risk factor for Irvine-Gass syndrome.Clinics (Sao Paulo, Brazil) · 2026Article
- Systemic inflammatory response index as a predictive biomarker for Irvine-Gass syndrome.International ophthalmology · 2025Article
- Association of systemic inflammatory biomarkers with ocular disease: a large population-based cross-sectional study.European journal of medical research · 2025Article
- Association between systemic immune inflammation index and cataract incidence from 2005 to 2008.Scientific reports · 2025Article
- Association of inflammatory markers and hematological inflammatory indices in predicting pseudoexfoliation.Bioinformation · 2025Article
- Hematological inflammation biomarkers in patients with pseudoexfoliation syndrome and pseudoexfoliation glaucoma.International journal of ophthalmology · 2025Article
- Clinical macular edema following uneventful cataract surgery in eyes without pre-existing fundus diseases: risk factors and treatment prognosis.BMC ophthalmology · 2024Article
- Congential nasolacrimal duct obstruction: investigating the role of systemic inflammation through novel biomakers.International ophthalmology · 2024Article
- Association between systemic immune-inflammation index and cataract among outpatient US adults.Frontiers in medicine · 2024Article
- Can the Pan-Immune Inflammation Value, Systemic Inflammatory Response Index, and Other Hematological Inflammatory Indices Be Clinically Used to Predict Pseudoexfoliation?Journal of clinical practice and research · 2024Article
- Systemic immuno-inflammatory index in patients with pseudoexfoliation syndrome and pseudoexfoliative glaucoma.Therapeutic advances in ophthalmologyArticle
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Authors and funding
3 authors at 3 institutions in 1 country.
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No grant is acknowledged in the PubMed record.
Abstract
backgroundTo evaluate the association between serum biomarkers and pseudophakic cystoid macular edema (PCME) in eyes without risk factors after uneventful phacoemulsification cataract surgery.
methodsThis is a case-control study. Patients without risk factors and who developed clinically significant PCME after uncomplicated phacoemulsification surgery were enrolled in the study. The age- and sex-matched control group that had normal fundus examination findings and 10/10 visual acuity in the first week, first month and following postoperative control visits was randomly recruited from the same study cohort. The neutrophil-to-lymphocyte ratio (NLR), platelet-to-lymphocyte ratio (PLR), and systemic immune-inflammation index (SII) were obtained from the preoperative complete blood count (CBC) test and compared between the two groups. Linear regression analysis was used to assess the relationship between central macular thickness (CMT) and biomarkers. A binary logistic regression model was generated to evaluate the significance of the biomarkers in predicting PCME. The receiver operating characteristic (ROC) curves of the significant parameters in the logistic regression model were presented to detect the area under the curve (AUC), the cut-off point, the sensitivity and the specificity.
resultsThe study cohort included 5352 patients. Of these patients, 52 (0.97%) met the inclusion criteria, and 60 age- and sex-matched patients were recruited as the control group. PLR, NLR, and SII were significantly different between the two groups (p = 0.006, p = 0.002, p < 0.001, respectively). According to the linear regression analysis, SII was found to have a significant relationship with CMT (p < 0.001). Only SII was assessed as significant in the logistic regression model (p = 0.046). In the ROC curve, the AUC of SII was 0.709. The sensitivity and specificity of SII for PCME prediction were 65.38% and 75%, respectively, and the cut-off point was 433.70.
conclusionSII is associated with the occurrence of PCME in eyes without risk factors after uneventful phacoemulsification surgery. SII could be a useful tool to predict PCME in eyes without risk factors.
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