Evidence map›Paper›PMID 36131247›Full record

ArticleBMC anesthesiology2022

Incidental finding of elevated pulmonary arterial pressures during liver transplantation and postoperative pulmonary complications.

Alexandre Joosten, François Martin Carrier, Aïmane Menioui, Philippe Van der Linden, Brenton Alexander, Audrey Coilly, Nicolas Golse, Marc-Antoine Allard, Valerio Lucidi, Daniel Azoulay and 13 more

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in BMC anesthesiology, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed, 1 pooled it
0.8field-weighted citation impact, top 28% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed, 1 synthesis or guideline pooled it, 6 citations in OpenAlex.

  1. International Liver Transplantation Society practice guideline update on portopulmonary hypertension.Liver transplantation : official publication of the American Association for the Study of Liver Diseases and the International Liver Transplantation Society · 2026
    Guideline
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

23 authors at 9 institutions in 4 countries.

Alexandre Joosten *Department of Anesthesiology and Intensive Care, Paris-Saclay University, Paul Brousse Hospital, Assistance Publique Hôpitaux de Paris (APHP), 12 Avenue Paul Vaillant Couturier, 94800, Villejuif, France. joosten-alexandre@hotmail.com.
François Martin Carrier *Department of Anesthesiology and Department of Medicine, Critical Care Division, Centre Hospitalier de L'Université de Montréal, Montréal, Québec, Canada.
Aïmane MeniouiDepartment of Anesthesiology, Erasme Hospital, Université Libre de Bruxelles, Brussels, Belgium.
Philippe Van der LindenDepartment of Anesthesiology, Brugmann Hospital, Université Libre de Bruxelles, Brussels, Belgium.
Brenton AlexanderDepartment of Anesthesiology, University of California San Diego, La Jolla, San Diego, CA, USA.
Audrey CoillyDepartment of Intensive Care, Paris-Saclay University, Paul Brousse Hospital, Assistance Publique Hôpitaux de Paris (APHP), Villejuif, France.
Nicolas GolseDepartment of Hepatobiliary Surgery and Liver Transplantation, Paris-Saclay University, Paul Brousse hospital, Assistance Publique Hôpitaux de Paris (APHP), Villejuif, France.
Marc-Antoine AllardDepartment of Hepatobiliary Surgery and Liver Transplantation, Paris-Saclay University, Paul Brousse hospital, Assistance Publique Hôpitaux de Paris (APHP), Villejuif, France.
Valerio LucidiDepartment of Hepatobiliary Surgery and Liver Transplantation, Erasme Hospital, Brussels, Belgium.
Daniel AzoulayDepartment of Hepatobiliary Surgery and Liver Transplantation, Paris-Saclay University, Paul Brousse hospital, Assistance Publique Hôpitaux de Paris (APHP), Villejuif, France.
Salima NailiDepartment of Anesthesiology and Intensive Care, Paris-Saclay University, Paul Brousse Hospital, Assistance Publique Hôpitaux de Paris (APHP), 12 Avenue Paul Vaillant Couturier, 94800, Villejuif, France.
Leila ToubalDepartment of Anesthesiology and Intensive Care, Paris-Saclay University, Paul Brousse Hospital, Assistance Publique Hôpitaux de Paris (APHP), 12 Avenue Paul Vaillant Couturier, 94800, Villejuif, France.
Maya MoussaDepartment of Anesthesiology and Intensive Care, Paris-Saclay University, Paul Brousse Hospital, Assistance Publique Hôpitaux de Paris (APHP), 12 Avenue Paul Vaillant Couturier, 94800, Villejuif, France.
Lydia KaramDepartment of Anesthesiology and Intensive Care, Paris-Saclay University, Paul Brousse Hospital, Assistance Publique Hôpitaux de Paris (APHP), 12 Avenue Paul Vaillant Couturier, 94800, Villejuif, France.
Hung PhamDepartment of Anesthesiology and Intensive Care, Paris-Saclay University, Paul Brousse Hospital, Assistance Publique Hôpitaux de Paris (APHP), 12 Avenue Paul Vaillant Couturier, 94800, Villejuif, France.
Edita LaukaityteDepartment of Anesthesiology and Intensive Care, Paris-Saclay University, Paul Brousse Hospital, Assistance Publique Hôpitaux de Paris (APHP), 12 Avenue Paul Vaillant Couturier, 94800, Villejuif, France.
Youcef AmaraDepartment of Anesthesiology and Intensive Care, Paris-Saclay University, Paul Brousse Hospital, Assistance Publique Hôpitaux de Paris (APHP), 12 Avenue Paul Vaillant Couturier, 94800, Villejuif, France.
Marc Lanteri-MinetDepartment of Anesthesiology and Intensive Care, Paris-Saclay University, Paul Brousse Hospital, Assistance Publique Hôpitaux de Paris (APHP), 12 Avenue Paul Vaillant Couturier, 94800, Villejuif, France.
Didier SamuelDepartment of Intensive Care, Paris-Saclay University, Paul Brousse Hospital, Assistance Publique Hôpitaux de Paris (APHP), Villejuif, France.
Olivier SitbonFaculty of Medicine, Paris-Saclay University, Le Kremlin-Bicêtre, France.
Marc HumbertFaculty of Medicine, Paris-Saclay University, Le Kremlin-Bicêtre, France.
Laurent SavaleFaculty of Medicine, Paris-Saclay University, Le Kremlin-Bicêtre, France.
Jacques DuranteauDepartment of Anesthesiology and Intensive Care, Paris-Saclay University, Paul Brousse Hospital, Assistance Publique Hôpitaux de Paris (APHP), 12 Avenue Paul Vaillant Couturier, 94800, Villejuif, France.
Hôpital Paul-Brousse · FRAssistance Publique – Hôpitaux de Paris · FRUniversité Paris-Saclay · FRUniversité Libre de Bruxelles · BEBicêtre Hospital · FRCentre Hospitalier de l’Université de Montréal · CAErasmus Hospital · BEInserm · FRUniversity of California, San Diego · US

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundIn patients with end stage liver disease (ESLD) scheduled for liver transplantation (LT), an intraoperative incidental finding of elevated mean pulmonary arterial pressure (mPAP) may be observed. Its association with patient outcome has not been evaluated. We aimed to estimate the effects of an incidental finding of a mPAP > 20 mmHg during LT on the incidence of pulmonary complications.

methodsWe examined all patients who underwent a LT at Paul-Brousse hospital between January 1,2015 and December 31,2020. Those who received: a LT due to acute liver failure, a combined transplantation, or a retransplantation were excluded, as well as patients for whom known porto-pulmonary hypertension was treated before the LT or patients who underwent a LT for other etiologies than ESLD. Using right sided pulmonary artery catheterization measurements made following anesthesia induction, the study cohort was divided into two groups using a mPAP cutoff of 20 mmHg. The primary outcome was a composite of pulmonary complications. Univariate and multivariable logistic regression analyses were performed to identify variables associated with the primary outcome. Sensitivity analyses of multivariable models were also conducted with other mPAP cutoffs (mPAP ≥ 25 mmHg and ≥ 35 mmHg) and even with mPAP as a continuous variable.

resultsOf 942 patients who underwent a LT, 659 met our inclusion criteria. Among them, 446 patients (67.7%) presented with an elevated mPAP (mPAP of 26.4 ± 5.9 mmHg). When adjusted for confounding factors, an elevated mPAP was not associated with a higher risk of pulmonary complications (adjusted OR: 1.16; 95%CI 0.8-1.7), nor with 90 days-mortality or any other complications. In our sensitivity analyses, we observed a lower prevalence of elevated mPAP when increasing thresholds (235 patients (35.7%) had an elevated mPAP when defined as ≥ 25 mmHg and 41 patients (6.2%) had an elevated mPAP when defined as ≥ 35 mmHg). We did not observe consistent association between a mPAP ≥ 25 mmHg or a mPAP ≥ 35 mmHg and our outcomes.

conclusionIncidental finding of elevated mPAP was highly prevalent during LT, but it was not associated with a higher risk of postoperative complications.

Indexed as

End Stage Liver DiseaseHypertension, PulmonaryLiver TransplantationArterial PressureHumansIncidental FindingsPostoperative ComplicationsPulmonary ArteryRetrospective StudiesHemodynamicLiver surgeryLiver transplantationPostoperative outcomesPulmonary arterial pressure

Identifiers

PMID36131247
PMCPMC9490933
OpenAlexW4296710491

What OpenQuestion holds

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LicenceCC BY
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.