Evidence map›Paper›PMID 36131241›Full record

ArticleBMC nephrology2022

SARS-CoV-2 in dialysis patients and the impact of vaccination.

Louise Rachel Moore, Noor Al-Jaddou, Harsha Wodeyar, Asheesh Sharma, Michael Schulz, Anirudh Rao, Kottarathil Abraham

Abstract read
In one paragraph

Article in BMC nephrology, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.

0numbers the graph read from it
0cells of the map it votes in
6citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

6 citing papers in PubMed.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Louise Rachel MooreLiverpool University Hospitals NHS FT, Liverpool, UK. louise.moore10@nhs.net.
Noor Al-JaddouLiverpool University Hospitals NHS FT, Liverpool, UK.
Harsha WodeyarLiverpool University Hospitals NHS FT, Liverpool, UK.
Asheesh SharmaLiverpool University Hospitals NHS FT, Liverpool, UK.
Michael SchulzLiverpool University Hospitals NHS FT, Liverpool, UK.
Anirudh RaoLiverpool University Hospitals NHS FT, Liverpool, UK.
Kottarathil AbrahamLiverpool University Hospitals NHS FT, Liverpool, UK.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundIn centre haemodialysis (ICHD) patients have been identified as high risk of contracting Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2) infection due to frequent healthcare contact and poor innate and adaptive immunity. Our ICHD patients were offered immunisation from January 2021. We aimed to assess outcomes following SARS-CoV-2 infection and report on the effect of vaccination in our ICHD patients.

methodsDemographics, SARS-CoV-2 status, hospitalisation, mortality and vaccination status were analysed. From 11

resultsSARS-CoV-2 infection occurred in 28.4% with 51.1% of them requiring hospitalisation in contrast to community infection rates of 13.9% and hospitalisation of 9.0%. 28-day mortality was 19.2% in comparison to 1.9% of the community. Mortality increased to 34.0% over the study period. Mortality over the study period was 1.8 times in infected patients (HR 1.81 (1.32-2.49) P < 0.001) despite adjustment for age, gender and ethnicity. 91.3% of ICHD patients have now received both doses of SARS-CoV-2 vaccinations.

conclusionsICHD patients are at increased risk of acquiring SARS-CoV-2, with increased rates of hospitalisation and mortality. The increased mortality extends well beyond the 28 days post-infection and persists in those who have recovered. Peaks and troughs in infection rates mirrored community trends. Preliminary data indicates that the SARS-CoV-2 vaccination provides protection to ICHD patients, with ICHD case rates now comparable to that of the local population.

Indexed as

COVID-19SARS-CoV-2COVID-19 VaccinesHumansRenal DialysisVaccinationCOVID-19 VaccinesDialysis patientsEfficacySARS-CoV-2Vaccination

Identifiers

PMID36131241
PMCPMC9490718

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.