Observational studyEuropean radiology experimental2022
Kat-ARC accelerated 4D flow CMR: clinical validation for transvalvular flow and peak velocity assessment.
Observational study in European radiology experimental, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers.
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Who cites it
13 citing papers in PubMed.
- Mitral Valve Repair vs. Replacement: Hemodynamics in Valve Surgery.Reviews in cardiovascular medicine · 2026Review
- Comparing transthoracic echocardiography, 2D and 4D flow cardiovascular magnetic resonance for quantitative valve assessment after percutaneous pulmonary valve implantation.European heart journal. Imaging methods and practice · 2026Article
- Article
- Intracranial pulse wave velocity using 4D flow MRI: method comparison and covariate analysis.Interface focus · 2025Article
- Clinical relevance of aortic conduit and reservoir function.Open heart · 2024Article
- Assessment of Tricuspid Regurgitation by Cardiac Magnetic Resonance Imaging: Current Role and Future Applications.Journal of clinical medicine · 2024Review
- Measuring global cerebrovascular pulsatility transmission using 4D flow MRI.Scientific reports · 2024Article
- Validation of 2D flow MRI for helical and vortical flows.Open heart · 2024Article
- Direct comparison of whole heart quantifications between different retrospective and prospective gated 4D flow CMR acquisitions.Frontiers in cardiovascular medicine · 2024Article
- Cardiac MR modelling of systolic and diastolic blood pressure.Open heart · 2023Article
- The Importance of Mitral Valve Prolapse Doming Volume in the Assessment of Left Ventricular Stroke Volume with Cardiac MRI.Medical sciences (Basel, Switzerland) · 2023Article
- Automated 4D flow cardiac MRI pipeline to derive peak mitral inflow diastolic velocities using short-axis cine stack: two centre validation study against echocardiographic pulse-wave doppler.BMC cardiovascular disorders · 2023Article
- Aortic flow is abnormal in HFpEF.Wellcome open research · 2023Article
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Authors and funding
19 authors.
Funding
Abstract
backgroundTo validate the k-adaptive-t autocalibrating reconstruction for Cartesian sampling (kat-ARC), an exclusive sparse reconstruction technique for four-dimensional (4D) flow cardiac magnetic resonance (CMR) using conservation of mass principle applied to transvalvular flow.
methodsThis observational retrospective study (2020/21-075) was approved by the local ethics committee at the University of East Anglia. Consent was waived. Thirty-five patients who had a clinical CMR scan were included. CMR protocol included cine and 4D flow using Kat-ARC acceleration factor 6. No respiratory navigation was applied. For validation, the agreement between mitral net flow (MNF) and the aortic net flow (ANF) was investigated. Additionally, we checked the agreement between peak aortic valve velocity derived by 4D flow and that derived by continuous-wave Doppler echocardiography in 20 patients.
resultsThe median age of our patient population was 63 years (interquartile range [IQR] 54-73), and 18/35 (51%) were male. Seventeen (49%) patients had mitral regurgitation, and seven (20%) patients had aortic regurgitation. Mean acquisition time was 8 ± 4 min. MNF and ANF were comparable: 60 mL (51-78) versus 63 mL (57-77), p = 0.310). There was an association between MNF and ANF (rho = 0.58, p < 0.001). Peak aortic valve velocity by Doppler and 4D flow were comparable (1.40 m/s, [1.30-1.75] versus 1.46 m/s [1.25-2.11], p = 0.602) and also correlated with each other (rho = 0.77, p < 0.001).
conclusionsKat-ARC accelerated 4D flow CMR quantified transvalvular flow in accordance with the conservation of mass principle and is primed for clinical translation.
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