Evidence map›Paper›PMID 36131131›Full record

ArticleClinical hematology international2022

High Expression of the Costimulatory Checkpoint Factor DNAM-1 by CD4

Katrine Fladeland Iversen, Line Nederby, Thomas Lund, Torben Plesner

Open access · diamondAbstract read
In one paragraph

Article in Clinical hematology international, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
0.3field-weighted citation impact, top 39% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed, 2 citations in OpenAlex.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors at 3 institutions in 1 country.

Katrine Fladeland IversenInstitute of Regional Health Science, University of Southern Denmark, Beriderbakken 4, 7100, Vejle, Denmark. katrine.fladeland.iversen@rsyd.dk.ORCID http://orcid.org/0000-0003-4494-9034
Line NederbyDepartment of Biochemistry and Immunology, Lillebaelt Hospital, University Hospital of Southern Denmark, Beriderbakken 4, 7100, Vejle, Denmark.
Thomas LundDepartment of Hematology, Odense University Hospital, J.B. Winsløvs Vej 4, 5000, Odense C, Denmark.
Torben PlesnerInstitute of Regional Health Science, University of Southern Denmark, Beriderbakken 4, 7100, Vejle, Denmark.
University of Southern Denmark · DKLillebaelt Hospital · DKOdense University Hospital · DK

Funding

Fonden til Lægevidenskabens Fremme 19-L-0185Lægeforeningen 2019-3780/67Region of Southern Denmark 2019 19/12124/A233
6 · The paper itself

Abstract

Multiple myeloma is an incurable disease characterized by unregulated growth of malignant plasma cells in the bone marrow (BM). Tumor-induced dysfunction of T-cells may be responsible for immune evasion and failure of immunotherapy. Therefore, a better understanding of the phenotype of T-cells at the tumor site is needed. We assessed the expression of immune regulatory receptors on T-cell subsets from peripheral blood (PB) and BM using multicolor flow cytometry. Paired PB and BM samples were collected from newly diagnosed, treatment-naïve myeloma patients (n = 19) and patients progressing during treatment with the CD38 monoclonal antibody daratumumab alone or in combination with other anti-myeloma drugs (n = 39). We observed that CD4

Indexed as

Bone marrow microenvironmentCheckpoint inhibitorDaratumumabImmunotherapyMultiple myelomaTreatment

Identifiers

PMID36131131
PMCPMC9492812
OpenAlexW4292401652

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.