Evidence map›Paper›PMID 36131128›Full record

ReviewClinical hematology international2022

The EBMT Immune Effector Cell Nursing Guidelines on CAR-T Therapy: A Framework for Patient Care and Managing Common Toxicities.

Rose Ellard, Michelle Kenyon, Daphna Hutt, Erik Aerts, Maaike de Ruijter, Christian Chabannon, Mohamad Mohty, Silvia Montoto, Elisabeth Wallhult, John Murray

Open access · diamondAbstract readReview
In one paragraph

Review in Clinical hematology international, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers.

0numbers the graph read from it
0cells of the map it votes in
17citing papers in PubMed
2.4field-weighted citation impact, top 9% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

17 citing papers in PubMed, 23 citations in OpenAlex.

  1. Review
  2. Review
  3. Review
  4. Article
  5. Review
  6. Dependence and clinical fragility in hematopoietic stem cell transplant and CAR-T therapy: a retrospective study.Supportive care in cancer : official journal of the Multinational Association of Supportive Care in Cancer · 2025
    Article
  7. Article
  8. Review
  9. Review
  10. Article
  11. Article
  12. Review
  13. Article
  14. Review
  15. Article
  16. Certainty, wine and haematology.Bone marrow transplantation · 2023
    Article
  17. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors at 10 institutions in 6 countries.

Rose EllardThe Royal Marsden Hospitals NHS Foundation Trust, Fulham Road, London, SW3 6JJ, UK. Rose.Ellard@nhs.net.
Michelle KenyonKings College Hospital NHS Foundation Trust, London, UK.
Daphna HuttThe Edmond and Lily Safra Children's Hospital, Jerusalem, Israel.
Erik AertsUniversity Hospital Zurich, Zurich, Switzerland.
Maaike de RuijterAmsterdam UMC Location VUmc, Amsterdam, The Netherlands.
Christian ChabannonInstitut Paoli-Calmettes, Marseille, France.
Mohamad MohtySorbonne University, INSERM, Saint-Antoine Hospital, Paris, France.
Silvia MontotoBarts Health NHS Trust, London, UK.
Elisabeth WallhultSahlgrenska University Hospital, Göteborg, Sweden.
John MurrayChristie Hospital NHS Foundation Trust, London, UK.
Amsterdam University Medical Centers · NLBarts Health NHS Trust · GBEdmond and Lily Safra Children's Hospital · ILInserm · FRInstitut Paoli-Calmettes · FRKing's College Hospital NHS Foundation Trust · GBRoyal Marsden NHS Foundation Trust · GBSahlgrenska University Hospital · SEThe Christie NHS Foundation Trust · GBUniversity Hospital of Zurich · CH

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Chimeric antigen receptor T-cell (CAR T) therapy is a new and rapidly developing field. Centers across the world are gaining more experience using these innovative anti-cancer treatments, transitioning from the 'bench' to the 'bedside', giving benefit to an increasing number of patients. For those with some refractory hematological malignancies, CAR-T may offer a treatment option that was not available a few years ago.CAR-T therapy is an immune effector cell and precision/personalized medicine treatment which is tailored to the individual patient and associated with a variety of unique adverse events and toxicities that necessitate specialist nursing/medical vigilance in an appropriate clinical setting. Subtle unrecognized signs and symptoms can result in rapid deterioration and, possibly, life threatening cardiorespiratory and/or neurological sequelae.These guidelines have been prepared for nurses working in cellular therapy in inpatient, outpatient and ambulatory settings. Many nurses will encounter cellular therapy recipients indirectly, during the referral process, following discharge, and when patients are repatriated back to local centers. The aim of these guidelines is to provide all nurses with a practice framework to enable recognition, monitoring and grading of CAR-T therapy-associated toxicities, and to support and nurse these highly complex patients with confidence.They have been developed under the auspices of several bodies of the European society for Blood and Marrow Transplantation (EBMT), by experienced health professionals, and will be a valuable resource to all practitioners working in cellular therapy.

Indexed as

CAR-TCAR-T therapyCellular therapyImmunotherapyNursingNursing education

Identifiers

PMID36131128
PMCPMC9263804
OpenAlexW4284895711

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.