Evidence map›Paper›PMID 36131028›Full record

ArticleThe Journal of antibiotics2022

Butorphanol inhibits angiogenesis and migration of hepatocellular carcinoma and regulates MAPK pathway.

Peilei Guo, Qiangfu Hu, Jiandong Wang, Longzhu Hai, Xiaohong Nie, Qingyuan Zhao

Open access · hybridAbstract read
PubMed Publisher
In one paragraph

Article in The Journal of antibiotics, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
1.2field-weighted citation impact, top 22% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed, 8 citations in OpenAlex.

  1. Review
  2. Article
  3. Article
  4. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 1 institution in 1 country.

Peilei GuoDepartment of Anesthesiology, The Fifth Affiliated Hospital of Zhengzhou University, Zhengzhou, 450052, Henan, China. guopeilei_dr@126.com.
Qiangfu HuDepartment of Anesthesiology, The Fifth Affiliated Hospital of Zhengzhou University, Zhengzhou, 450052, Henan, China.
Jiandong WangDepartment of Anesthesiology, The Fifth Affiliated Hospital of Zhengzhou University, Zhengzhou, 450052, Henan, China.
Longzhu HaiDepartment of Anesthesiology, The Fifth Affiliated Hospital of Zhengzhou University, Zhengzhou, 450052, Henan, China.
Xiaohong NieDepartment of Anesthesiology, The Fifth Affiliated Hospital of Zhengzhou University, Zhengzhou, 450052, Henan, China.
Qingyuan ZhaoDepartment of Anesthesiology, The Fifth Affiliated Hospital of Zhengzhou University, Zhengzhou, 450052, Henan, China.
Fifth Affiliated Hospital of Zhengzhou University · CN

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Butorphanol, a synthetic opioid, exerts analgesic and anti-inflammatory effects against pathogenic diseases. Butorphanol repressed malignant behaviors of tumor cells. In this study, the role of butorphanol in hepatocellular carcinoma was evaluated. Firstly, hepatocellular carcinoma cells were treated with butorphanol. The results showed that butorphanol decreased cell viability of hepatocellular carcinoma cells. Cell proliferation and metastasis of hepatocellular carcinoma cells were inhibited by butorphanol. Secondly, butorphanol suppressed angiogenesis, and reduced phosphorylation levels of p38 and JNK in hepatocellular carcinoma cells. Thirdly, butorphanol reduced in vivo tumor growth of hepatocellular carcinoma in nude mice. Butorphanol reduced tumor micro-vascular density (MVD) and repressed lung metastasis. In conclusion, butorphanol exerted anti-angiogenic and anti-metastatic effects on hepatocellular carcinoma and induced inactivation of MAPKs signaling.

Indexed as

Carcinoma, HepatocellularLiver NeoplasmsAnalgesics, OpioidAnimalsAnti-Inflammatory AgentsButorphanolCell Line, TumorCell ProliferationMiceMice, NudeNeovascularization, PathologicAnalgesics, OpioidAnti-Inflammatory AgentsButorphanol

Identifiers

PMID36131028
OpenAlexW4296691525

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.