ArticleNature2022
A cellular hierarchy in melanoma uncouples growth and metastasis.
Erratum issuedOpen access · greenAbstract read
In one paragraph
Article in Nature, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. An erratum has been issued. Cited by 161 papers.
0numbers the graph read from it
0cells of the map it votes in
161citing papers in PubMed
19.6field-weighted citation impact, top 1% of its field
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
161 citing papers in PubMed, 234 citations in OpenAlex.
- MITF-Driven melanoma plasticity as a core mechanism of therapy resistance: integrating microenvironmental signaling, mechanotransduction, and metabolic reprogramming.Cell cycle (Georgetown, Tex.) · 2026Review
- Niches in cancer: from primary tumors to metastatic disease.Journal of hematology & oncology · 2026Review
- Decoding epithelial-mesenchymal transitions with multi-omics.Nature reviews. Genetics · 2026Review
- Mechanistic modeling reveals a configurable AP-1 network governing cell-state heterogeneity and adaptive plasticity in melanoma cells.Cell reports · 2026Article
- Melanoma evolution in the lymph node shapes systemic outcomes.bioRxiv : the preprint server for biology · 2026Article
- A Multistep Immune-Competent Genetically Engineered Mouse Model Reveals Phenotypic Plasticity in Uveal Melanoma.Cancer research · 2026Article
- Targeted therapy in BRAF‑mutant melanoma: Advances and challenges (Review).International journal of oncology · 2026Review
- Metastatic Cancers Exploit Vagal Sensory Neurons and Neural Repair Programs to Colonize New Tissues.Research square · 2026Article
- Tumor evolution: signaling pathways, molecular mechanisms and therapeutic targets.Signal transduction and targeted therapy · 2026Review
- Tumor heterogeneity: development, mechanisms, and therapeutic implications.Signal transduction and targeted therapy · 2026Review
- MCFST: spatial domain identification method based on multi-view graph convolutional network and graph fusion network.Bioinformatics (Oxford, England) · 2026Article
- Adherent-to-suspension transition modulates circulating tumor cell dynamics and metastatic potential in melanoma.Molecules and cells · 2026Article
- Melanoma cell states shape spatial tumor-immune ecosystems to dictate the efficacy of anti-PD1 immunotherapy.Journal for immunotherapy of cancer · 2026Article
- Travelling Waves in Gene Expression: A Mathematical Model of Cell-State Dynamics in Melanoma.Bulletin of mathematical biology · 2026Article
- An Itch Receptor Drives Melanoma.bioRxiv : the preprint server for biology · 2026Article
- Neural crest gene regulatory networks as drivers of development, diversification and disease.Nature reviews. Molecular cell biology · 2026Review
- A Targetable Developmental Program Coregulates Angiogenesis and Immune Evasion in Melanoma.Cancer discovery · 2026Article
- Spatial transcriptomics reveals influence of microenvironment on intrinsic fates in melanoma therapy resistance.Genome biology · 2026Article
- A MAFG~MITF complex drives melanoma phenotype switching and progression.Nature communications · 2026Article
- mTOR inhibition enhances the antitumor efficacy of pan-RAF-MEK blockade by inhibiting the ATF4-MTHFD2 pathway.Cell death & disease · 2026Article
101 more citing papers are in PubMed but not listed here.
Corrections and comments
- Commented on by
- Erratum issued
Authors and funding
32 authors at 11 institutions in 6 countries.
Panagiotis KarrasLaboratory for Molecular Cancer Biology, Center for Cancer Biology, VIB, Leuven, Belgium.
Ignacio Bordeu *Department of Applied Mathematics and Theoretical Physics, Centre for Mathematical Sciences, University of Cambridge, Cambridge, UK.
Joanna Pozniak *Laboratory for Molecular Cancer Biology, Center for Cancer Biology, VIB, Leuven, Belgium.
Ada Nowosad *Laboratory for Molecular Cancer Biology, Center for Cancer Biology, VIB, Leuven, Belgium.
Cecilia PazziLaboratory for Molecular Cancer Biology, Center for Cancer Biology, VIB, Leuven, Belgium.ORCID http://orcid.org/0000-0001-5172-3215
Nina Van RaemdonckLaboratory for Molecular Cancer Biology, Center for Cancer Biology, VIB, Leuven, Belgium.ORCID http://orcid.org/0000-0002-8913-6275
Ewout LandeloosLaboratory for Molecular Cancer Biology, Center for Cancer Biology, VIB, Leuven, Belgium.ORCID http://orcid.org/0000-0002-9128-6432
Yannick Van HerckDepartment of General Medical Oncology, UZ Leuven, Leuven, Belgium.
Dennis PedriLaboratory for Molecular Cancer Biology, Center for Cancer Biology, VIB, Leuven, Belgium.ORCID http://orcid.org/0000-0001-6619-0132
Greet BervoetsLaboratory for Molecular Cancer Biology, Center for Cancer Biology, VIB, Leuven, Belgium.
Samira MakhzamiLaboratory for Molecular Cancer Biology, Center for Cancer Biology, VIB, Leuven, Belgium.
Jia Hui KhooBGI-Shenzhen, Shenzhen, China.ORCID http://orcid.org/0000-0001-8385-5669
Benjamin PavieVIB BioImaging Core, VIB Center for Brain and Disease Research, Leuven, Belgium.ORCID http://orcid.org/0000-0002-0249-3844
Jochen LamoteFACS Expertise Center, Center for Cancer Biology, VIB, Leuven, Belgium.
Oskar Marin-BejarLaboratory for Molecular Cancer Biology, Center for Cancer Biology, VIB, Leuven, Belgium.ORCID http://orcid.org/0000-0002-6889-6566
Michael DewaeleLaboratory for Molecular Cancer Biology, Center for Cancer Biology, VIB, Leuven, Belgium.
Han LiangBGI-Shenzhen, Shenzhen, China.
Xingju ZhangBGI-Shenzhen, Shenzhen, China.
Yichao HuaDepartment of Oncology, KU Leuven, Leuven, Belgium.ORCID http://orcid.org/0000-0002-1695-172X
Jasper WoutersCenter for Brain & Disease Research, VIB-KU Leuven, Leuven, Belgium.ORCID http://orcid.org/0000-0002-7129-2990
Robin BrowaeysData Mining and Modeling for Biomedicine Group, VIB Center for Inflammation Research, Ghent, Belgium.
Gabriele BergersDepartment of Oncology, KU Leuven, Leuven, Belgium.
Yvan SaeysData Mining and Modeling for Biomedicine Group, VIB Center for Inflammation Research, Ghent, Belgium.ORCID http://orcid.org/0000-0002-0415-1506
Francesca BosisioLaboratory for Translational Cell and Tissue Research, Department of Imaging and Pathology, KU Leuven, Leuven, Belgium.ORCID http://orcid.org/0000-0002-8874-2003
Joost van den OordLaboratory for Translational Cell and Tissue Research, Department of Imaging and Pathology, KU Leuven, Leuven, Belgium.
Diether LambrechtsLaboratory of Translational Genetics, Center for Cancer Biology, VIB, Leuven, Belgium.ORCID http://orcid.org/0000-0002-3429-302X
Anil K RustgiHerbert Irving Comprehensive Center, Columbia University Irving Medical Center, New York, USA.
Oliver BechterDepartment of General Medical Oncology, UZ Leuven, Leuven, Belgium.ORCID http://orcid.org/0000-0003-0667-3284
Cedric BlanpainLaboratory of Stem Cells and Cancer, Université Libre de Bruxelles (ULB), Brussels, Belgium.ORCID http://orcid.org/0000-0002-4028-4322
Benjamin D SimonsDepartment of Applied Mathematics and Theoretical Physics, Centre for Mathematical Sciences, University of Cambridge, Cambridge, UK.ORCID http://orcid.org/0000-0002-3875-7071
Florian RambowLaboratory for Molecular Cancer Biology, Center for Cancer Biology, VIB, Leuven, Belgium. florian.rambow@kuleuven.vib.be.
Jean-Christophe MarineLaboratory for Molecular Cancer Biology, Center for Cancer Biology, VIB, Leuven, Belgium. jeanchristophe.marine@kuleuven.vib.be.ORCID http://orcid.org/0000-0003-2433-9837
VIB-KU Leuven Center for Cancer Biology · BEBGI Group (China) · CNGhent University · BEKU Leuven · BEUniversitair Ziekenhuis Leuven · BEColumbia University Irving Medical Center · USGerman Cancer Research Center · DEUniversité Libre de Bruxelles · BEUniversity of Cambridge · GBVIB-KU Leuven Center for Brain & Disease Research · BEWellcome/MRC Cambridge Stem Cell Institute · GB
Funding
Tumor Biology and Microenvironment ProgramP30CA013696 · NCI · COLUMBIA UNIV NEW YORK MORNINGSIDE · PI Anil K Rustgi · 1985 to 2026
$115.3MThe LIN28b-Let7-IMP1 axis in colonic epithelial biologyR01DK056645 · NIDDK · UNIVERSITY OF PENNSYLVANIA · PI RUSTGI, ANIL K · 2000 to 2021
$6.8MMedical Research Council MC_PC_17230NCI NIH HHS P30 CA013696NIDDK NIH HHS R01 DK056645Wellcome TrustWellcome Trust 219478/Z/19/Z
Abstract
Although melanoma is notorious for its high degree of heterogeneity and plasticity
Indexed as
Cell ProliferationMelanomaNeoplasm MetastasisAnimalsCell CommunicationCell DifferentiationCell LineageCell TrackingCellular ReprogrammingEndothelial CellsMesodermMiceNeural CrestPhenotypeSingle-Cell AnalysisTranscriptome
Identifiers
What OpenQuestion holds
Textmetadata
LicenceTDM
Read underepoch 390
Registered trials
None linked
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.