ArticleNature2022
CLN3 is required for the clearance of glycerophosphodiesters from lysosomes.
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Article in Nature, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 86 papers.
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0cells of the map it votes in
86citing papers in PubMed
14.3field-weighted citation impact, top 1% of its field
What it found
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
86 citing papers in PubMed, 133 citations in OpenAlex.
- Long-Term Open-Label Study Evaluating Oral Miglustat Treatment in Patients With Neuronal Ceroid Lipofuscinosis Type 3.Neurology · 2025Trial
- The SLC-ome of membrane transport: from molecular discovery to physiology and clinical applications.Physiological reviews · 2026Review
- The Batten disease protein CLN8 is a stereospecific acyltransferase in bis(monoacylglycero)phosphate biosynthesis.Nature cell biology · 2026Article
- Batten disease protein CLN8 enables a non-canonical phospholipid synthesis pathway.Nature cell biology · 2026Article
- CLN8 recycles glycerol backbones for BMP.Nature cell biology · 2026Article
- Robust analytical methods for bis(monoacylglycero)phosphate profiling in health and disease.Nature protocols · 2026Review
- Mapping brain cell-type-specific diversity of lysosomal proteins.Cell research · 2026Article
- FILM: mapping organellar metabolism by mid-infrared photothermal-modulated fluorescence.Nature methods · 2026Article
- Lysosome: not only for digestion but also for production.Life metabolism · 2026Article
- Lysosomes contribute to the synthesis of tricarboxylic acid-related metabolites in the hippocampus.Life metabolism · 2026Article
- Modeling CLN3 Batten disease in astrocytes reveals alterations in mitochondria homeostasis, fatty acid metabolism and oxidative stress response.Journal of biomedical science · 2026Article
- Toward Early Diagnosis and Therapeutic Discovery in CLN3 Disease: A Computational Biomarker Discovery Framework.medRxiv : the preprint server for health sciences · 2026Article
- FILM: Mapping organellar metabolism by mid-infrared photothermal modulated fluorescence.ArXiv · 2026Article
- Lipofuscin accumulation in aging and CLN1 is associated with deficient de-S-acylation, lyso-mitochondrial dysfunction, and lipid dyshomeostasis.Acta neuropathologica · 2026Article
- Visual Recovery and Neurological Stabilization Following Miglustat Treatment in Pediatric CLN3 Disease.Journal of child neurology · 2026Article
- Granulin loss and TMEM106B risk converge on lysosomal C-terminal fragment pathology in frontotemporal dementia.bioRxiv : the preprint server for biology · 2026Article
- Translational lipidomics reveals BMP and its precursor LPG as biomarkers for CLN5 Batten disease.bioRxiv : the preprint server for biology · 2026Article
- PPa1 insufficiency drives lysosomal storage disease and inflammatory macrophage expansion in the bone marrow.bioRxiv : the preprint server for biology · 2026Article
- In vivo endosomal escape assay identifies mechanisms for efficient hepatic LNP delivery.Nature biotechnology · 2026Article
- CLN3 mediates chloride efflux from lysosomes.Neuron · 2026Article
26 more citing papers are in PubMed but not listed here.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
16 authors at 7 institutions in 2 countries.
Nouf N LaqtomDepartment of Chemical Engineering, Stanford University, Stanford, CA, USA.
Wentao DongDepartment of Chemical Engineering, Stanford University, Stanford, CA, USA.
Uche N MedohDepartment of Chemical Engineering, Stanford University, Stanford, CA, USA.
Andrew L CangelosiDepartment of Biology, Massachusetts Institute of Technology, Cambridge, MA, USA.
Vimisha DharamdasaniWhitehead Institute for Biomedical Research, Cambridge, MA, USA.
Sze Ham ChanWhitehead Institute for Biomedical Research, Cambridge, MA, USA.
Tenzin KunchokWhitehead Institute for Biomedical Research, Cambridge, MA, USA.
Caroline A LewisWhitehead Institute for Biomedical Research, Cambridge, MA, USA.
Ivonne HeinzeLeibniz Institute on Aging-Fritz Lipmann Institute, Jena, Germany.
Rachel TangWalther Straub Institute of Pharmacology and Toxicology, Faculty of Medicine, Ludwig-Maximilians-Universität, Munich, Germany.
Christian GrimmWalther Straub Institute of Pharmacology and Toxicology, Faculty of Medicine, Ludwig-Maximilians-Universität, Munich, Germany.ORCID http://orcid.org/0000-0002-0177-5559
An N Dang DoDivision of Translational Medicine, Eunice Kennedy Shriver National Institute of Child Health and Human Development, NIH, Bethesda, MD, USA.
Forbes D PorterDivision of Translational Medicine, Eunice Kennedy Shriver National Institute of Child Health and Human Development, NIH, Bethesda, MD, USA.ORCID http://orcid.org/0000-0001-9397-0046
Alessandro OriLeibniz Institute on Aging-Fritz Lipmann Institute, Jena, Germany.ORCID http://orcid.org/0000-0002-3046-0871
David M Sabatini *
Monther Abu-Remaileh *Department of Chemical Engineering, Stanford University, Stanford, CA, USA. monther@stanford.edu.
Whitehead Institute for Biomedical Research · USStanford University · USEunice Kennedy Shriver National Institute of Child Health and Human Development · USLeibniz Institute on Aging - Fritz Lipmann Institute (FLI) · DELudwig-Maximilians-Universität München · DEAllen Institute · USStanford Health Care · US
Funding
Regulation of the mTOR Pathway By NutrientsR01CA103866 · NCI · WHITEHEAD INSTITUTE FOR BIOMEDICAL RES · PI WEISSMAN, JONATHAN S. · 2004 to 2021
$7.0MCell Growth Signaling in Cancer DevelopmentR01CA129105 · NCI · WHITEHEAD INSTITUTE FOR BIOMEDICAL RES · PI WEISSMAN, JONATHAN S. · 2008 to 2021
$5.9MClinical Investigations of Inborn Errors of MetabolismZIAHD008989 · NICHD · EUNICE KENNEDY SHRIVER NATIONAL INSTITUTE OF CHILD HEALTH & HUMAN DEVELOPMENT · PI PORTER, FORBES · 2020 to 2025
$5.1MInnovations and mechanisms in tumor subcellular metabolismDP2CA271386 · NCI · STANFORD UNIVERSITY · PI ABU-REMAILEH, MONTHER · 2021 to 2024
$2.4MStanford Chem-H Chemistry/Biology Interface Predoctoral Training ProgramT32GM120007 · NIGMS · STANFORD UNIVERSITY · PI BERTOZZI, CAROLYN · 2016 to 2020
$1.2MLeucine Sensing by the mTORC1 Pathway in the LiverF31DK113665 · NIDDK · MASSACHUSETTS INSTITUTE OF TECHNOLOGY · PI CANGELOSI, ANDREW LOUIS · 2018 to 2021
$181kIntramural NIH HHS ZIA HD008989NCI NIH HHS DP2 CA271386NCI NIH HHS R01 CA103866NCI NIH HHS R01 CA129105NIDDK NIH HHS F31 DK113665NIGMS NIH HHS T32 GM120007
Abstract
Lysosomes have many roles, including degrading macromolecules and signalling to the nucleus
Indexed as
EstersGlycerophospholipidsInositol PhosphatesLysosomesMembrane GlycoproteinsMolecular ChaperonesAnimalsBiomarkersChildHumansLysosomal Storage DiseasesMiceNeuronal Ceroid-LipofuscinosesBiomarkersCLN3 protein, humanCLN3 protein, mouseEstersGlycerophospholipidsglycerylphosphoinositolInositol PhosphatesMembrane GlycoproteinsMolecular Chaperones
Identifiers
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.