ArticleNature2022
Unified rhombic lip origins of group 3 and group 4 medulloblastoma.
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Article in Nature, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 111 papers.
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0cells of the map it votes in
111citing papers in PubMed
14.4field-weighted citation impact, top 1% of its field
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Who cites it
111 citing papers in PubMed, 150 citations in OpenAlex.
- Paediatric therapeutic development workshop on medulloblastoma.British journal of cancer · 2026Review
- Divergent medulloblastoma chromatin states disclose KDM2B as a selective dependency.Nature genetics · 2026Article
- Spatial and single-cell dissection of medulloblastoma identifies developmental hierarchies and a prognostic PPIA-BSG tumor-immune axis.Journal of translational medicine · 2026Article
- Primary cervical multifocal medulloblastoma: a unique case report and review of the literature.European spine journal : official publication of the European Spine Society, the European Spinal Deformity Society, and the European Section of the Cervical Spine Research Society · 2026Article
- Organoids as brain tumour models: bridging the translational gap.Disease models & mechanisms · 2026Review
- From chromatin dynamics to brain disease: Polycomb-Trithorax mechanisms in neurodevelopment.Trends in neurosciences · 2026Review
- Differentially Methylated Regions in Human Rhombic Lip Compartments Are Enriched in Putative Active Enhancers, Human Accelerated Regions, and Medulloblastoma Copy Number Aberrations.Cerebellum (London, England) · 2026Article
- From developmental origins to relapse: molecular and therapeutic insights in medulloblastoma.Child's nervous system : ChNS : official journal of the International Society for Pediatric Neurosurgery · 2026Review
- Pediatric medulloblastoma.Child's nervous system : ChNS : official journal of the International Society for Pediatric Neurosurgery · 2026Review
- Subgroup-Specific Associations of GRIA Genes Encoding AMPA Glutamate Receptor Subunits with Patient Survival in Medulloblastoma.Neuromolecular medicine · 2026Article
- Comprehensive proteogenomic characterization reveals clinically relevant molecular subtypes associated with medulloblastoma progression.Experimental & molecular medicine · 2026Article
- Modeling medulloblastoma pathogenesis and treatment in human cerebellar organoids.Genes & development · 2026Article
- A Rare Nestin-Expressing Granule Cell Precursor subpopulation Underlies SHH Medulloblastoma Formation.bioRxiv : the preprint server for biology · 2026Article
- GPC6 facilitates progression of SHH-subgroup medulloblastoma by enhancing Hedgehog secretion and signaling responses.Journal of biomedical research · 2026Article
- Integration of human and mouse single-cell transcriptomes of the developing cerebellum nominates cells-of-origin for group 3 and 4 medulloblastoma.BMC cancer · 2026Article
- A tumor-associated photoreceptor signature unifies distinct central nervous system malignancies.Cancer cell · 2026Article
- Building the Bergmann glial scaffold: Early arrivals and stops along the way in human cerebellar development.Proceedings of the National Academy of Sciences of the United States of America · 2026Article
- M-PACT leverages cell-free DNA methylomes to achieve robust classification of pediatric brain tumors.Nature cancer · 2026Article
- Developmental determinants of male bias in medulloblastoma.bioRxiv : the preprint server for biology · 2026Article
- Fluid shear stress activates a targetable mechano-metastatic cascade to promote medulloblastoma metastasis.Nature biomedical engineering · 2026Article
51 more citing papers are in PubMed but not listed here.
Corrections and comments
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Authors and funding
30 authors at 6 institutions in 2 countries.
Kyle S Smith *Department of Developmental Neurobiology, St Jude Children's Research Hospital, Memphis, TN, USA.
Laure Bihannic *Department of Developmental Neurobiology, St Jude Children's Research Hospital, Memphis, TN, USA.
Brian L Gudenas *Department of Developmental Neurobiology, St Jude Children's Research Hospital, Memphis, TN, USA.
Parthiv HaldipurCenter for Integrative Brain Research, Seattle Children's Research Institute, Seattle, WA, USA.
Ran TaoDepartment of Developmental Neurobiology, St Jude Children's Research Hospital, Memphis, TN, USA.
Qingsong GaoDepartment of Developmental Neurobiology, St Jude Children's Research Hospital, Memphis, TN, USA.
Yiran LiDepartment of Developmental Neurobiology, St Jude Children's Research Hospital, Memphis, TN, USA.
Kimberly A AldingerCenter for Integrative Brain Research, Seattle Children's Research Institute, Seattle, WA, USA.ORCID http://orcid.org/0000-0002-5406-8911
Igor Y IskusnykhDepartment of Anatomy and Neurobiology, University of Tennessee, Memphis, TN, USA.
Victor V ChizhikovDepartment of Anatomy and Neurobiology, University of Tennessee, Memphis, TN, USA.
Matthew ScogginsDepartment of Diagnostic Imaging, St Jude Children's Research Hospital, Memphis, TN, USA.
Silu ZhangDepartment of Diagnostic Imaging, St Jude Children's Research Hospital, Memphis, TN, USA.ORCID http://orcid.org/0000-0001-5336-5650
Angela EdwardsDepartment of Diagnostic Imaging, St Jude Children's Research Hospital, Memphis, TN, USA.ORCID http://orcid.org/0000-0003-2979-5508
Mei DengDepartment of Pediatrics, University of Washington, Seattle, WA, USA.
Ian A GlassDepartment of Pediatrics, University of Washington, Seattle, WA, USA.
Lynne M OvermanInstitute of Genetic Medicine, Newcastle University, Newcastle upon Tyne, UK.
Jake MillmanCenter for Integrative Brain Research, Seattle Children's Research Institute, Seattle, WA, USA.
Alexandria H SjoboenCenter for Integrative Brain Research, Seattle Children's Research Institute, Seattle, WA, USA.
Jennifer HadleyDepartment of Developmental Neurobiology, St Jude Children's Research Hospital, Memphis, TN, USA.ORCID http://orcid.org/0000-0003-1918-747X
Joseph GolserCenter for Integrative Brain Research, Seattle Children's Research Institute, Seattle, WA, USA.
Kshitij MankadDepartment of Radiology, Great Ormond Street Hospital for Children, London, UK.
Heather SheppardDepartment of Pathology, St Jude Children's Research Hospital, Memphis, TN, USA.ORCID http://orcid.org/0000-0002-9623-2812
Arzu Onar-ThomasDepartment of Biostatistics, St Jude Children's Research Hospital, Memphis, TN, USA.
Amar GajjarDepartment of Oncology, St Jude Children's Research Hospital, Memphis, TN, USA.
Giles W RobinsonDepartment of Oncology, St Jude Children's Research Hospital, Memphis, TN, USA.ORCID http://orcid.org/0000-0001-7441-9486
Volker HovestadtDepartment of Pediatric Oncology, Dana Farber Cancer Institute, Boston, MA, USA.
Brent A OrrDepartment of Pathology, St Jude Children's Research Hospital, Memphis, TN, USA.ORCID http://orcid.org/0000-0003-0997-4728
Zoltán PatayDepartment of Diagnostic Imaging, St Jude Children's Research Hospital, Memphis, TN, USA.ORCID http://orcid.org/0000-0003-1479-9864
Kathleen J MillenCenter for Integrative Brain Research, Seattle Children's Research Institute, Seattle, WA, USA.ORCID http://orcid.org/0000-0001-9978-675X
Paul A NorthcottDepartment of Developmental Neurobiology, St Jude Children's Research Hospital, Memphis, TN, USA. paul.northcott@stjude.org.ORCID http://orcid.org/0000-0002-1220-5252
St. Jude Children's Research Hospital · USUniversity of Tennessee Health Science Center · USUniversity of Washington · USDana-Farber Cancer Institute · USGreat Ormond Street Hospital · GBNewcastle University · GB
Funding
Viral Vector Technology (VVTSR)P30CA021765 · NCI · ST. JUDE CHILDREN'S RESEARCH HOSPITAL · PI CHARLES ROBERTS · 1985 to 2026
$166.9MThe DNA Damage Response and Tumorigenesis in the BrainP01CA096832 · NCI · ST. JUDE CHILDREN'S RESEARCH HOSPITAL · PI BAKER, SUZANNE J. · 2003 to 2025
$38.0MLABORATORY OF DEVELOPMENTAL BIOLOGYR24HD000836 · NICHD · UNIVERSITY OF WASHINGTON · PI Ian Amos Glass · 1995 to 2026
$16.9MMechanisms of Brain Dysmorphology in MN1 C-Terminal Truncation Syndrome, a Novel Intellectual Developmental Disability Disorder P50HD103524 · NICHD · UNIVERSITY OF WASHINGTON · PI DANIEL DOHERTY · 2020 to 2026
$9.9MMentored Career DevelopmentKL2TR001854 · NCATS · UNIVERSITY OF SOUTHERN CALIFORNIA · PI Elizabeth Rhea Erwin Burner, Amy Elizabeth West · 2016 to 2026
$9.0MPathological Mechanisms of Human Cerebellar MalformationsR37NS095733 · NINDS · SEATTLE CHILDREN'S HOSPITAL · PI Kathleen Joyce Millen · 2021 to 2026
$5.5MA Bioengineering Approach to Develop a Laminar 3D Cerebellar Neuronal Circuit for Modeling Human CerebellumR01NS122902 · NINDS · SEATTLE CHILDREN'S HOSPITAL · PI Mary Elizabeth Hatten, Kathleen Joyce Millen · 2022 to 2026
$3.3MPathological Mechanisms of Human Cerebeller MalformationsR01NS095733 · NINDS · SEATTLE CHILDREN'S HOSPITAL · PI MILLEN, KATHLEEN JOYCE · 2016 to 2020
$3.0MMapping the Cerebellar Origins of Medulloblastoma SubgroupsR01CA270785 · NCI · ST. JUDE CHILDREN'S RESEARCH HOSPITAL · PI Paul Northcott · 2023 to 2026
$2.8MDissecting the Spectrum, Prevalence, and Molecular Mechanisms of Enhancer Hijacking in MedulloblastomaR01CA232143 · NCI · ST. JUDE CHILDREN'S RESEARCH HOSPITAL · PI NORTHCOTT, PAUL · 2018 to 2022
$1.9MMesenchymal-neuroepithelial interactions in the developing telencephalon.R01NS093009 · NINDS · UNIVERSITY OF TENNESSEE HEALTH SCI CTR · PI CHIZHIKOV, VIKTOR · 2016 to 2020
$1.7MMULTIMODAL PRECLINICAL CANCER IMAGING AND THERAPY RESEARCH SPECIALISTR50CA211481 · NCI · WASHINGTON UNIVERSITY · PI AKERS, WALTER JOHN · 2016 to 2020
$841kMedical Research Council MR/R006237/1NCATS NIH HHS KL2 TR001854NCI NIH HHS P01 CA096832NCI NIH HHS P30 CA021765NCI NIH HHS R01 CA232143NCI NIH HHS R01 CA270785NCI NIH HHS R50 CA211481NICHD NIH HHS P50 HD103524NICHD NIH HHS R24 HD000836NINDS NIH HHS R01 NS093009NINDS NIH HHS R01 NS095733NINDS NIH HHS R01 NS122902NINDS NIH HHS R37 NS095733Wellcome TrustWellcome Trust MR/R006237/1
Abstract
Medulloblastoma, a malignant childhood cerebellar tumour, segregates molecularly into biologically distinct subgroups, suggesting that a personalized approach to therapy would be beneficial
Indexed as
Cell LineageCerebellar NeoplasmsMedulloblastomaMetencephalonAnimalsCerebellumHumansMiceNeuronsProspective Studies
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.