ArticleScientific reports2022
Compounds from human odor induce attraction and landing in female yellow fever mosquitoes (Aedes aegypti).
Article in Scientific reports, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers.
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Who cites it
10 citing papers in PubMed.
- Functional characterization of AsOBP21f, an odorant-binding protein involved in human odor detection in the malaria vector Anopheles sinensis.Parasites & vectors · 2026Article
- Microbial Volatiles from Human Skin and Floral Nectar: Insufficiently Understood Adult Feeding Cues To Improve Odor-Based Traps for Aedes Vector Control.Journal of chemical ecology · 2025Review
- Spectral preferences of mosquitos are altered by odors.The Journal of experimental biology · 2025Article
- Differences in human skin volatiles between populations with high and low attraction to mosquitoes.Parasites & vectors · 2025Article
- Adaptive genomic signatures of globally invasive populations of the yellow fever mosquito Aedes aegypti.Nature ecology & evolution · 2025Article
- Editorial: Skin - confluence of vertebrate host defences, arthropod vectors, and vector-borne pathogens.Frontiers in immunology · 2025Article
- Context-specific variation in life history traits and behavior ofFrontiers in insect science · 2024Review
- A critical review of current laboratory methods used to evaluate mosquito repellents.Frontiers in insect science · 2024Review
- Biological determinants perpetuating the transmission dynamics of mosquito-borne flaviviruses.Emerging microbes & infections · 2023Review
- Development of an automated biomaterial platform to study mosquito feeding behavior.Frontiers in bioengineering and biotechnology · 2023Article
Corrections and comments
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Authors and funding
2 authors.
Funding
Abstract
The female Aedes aegypti mosquito is a vector of many human diseases such as yellow fever, dengue, and Zika. Transmission of these viruses occurs when an infected female mosquito locates a suitable human host, alights, and blood feeds. Aedes aegypti use human-emitted odors, as well as heat and visual cues, for host location. However, none of the previously identified human-produced compounds induce significant orientation and landing on a human host. Here we show that female yellow fever mosquitoes orient to and land on a mixture of compounds identified from human skin rubbings. Using odor collection, extraction, a two-choice, bioassay-guided fractionation, and chemical analysis, we identified mixtures of 2-ketoglutaric acid and L-lactic acid as landing attractants for female Ae. aegypti. The mixture of pyruvic acid and L-lactic acid were also found to be weakly attractive. Using ratio-response assays, we found that the attraction and alighting behaviors of the mosquitoes were directly related to the ratio of these compounds presented on the surface of the glass assay beads, suggesting that these compounds could mediate landing on a human host even at sub-nanogram dosages. The newly identified compounds fill a gap in our knowledge of odor-mediated attraction of Ae. aegypti and may lead to the development of new attractant-based mosquito control tactics.
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