ArticleNature communications2022
Resolving molecular diffusion and aggregation of antibody proteins with megahertz X-ray free-electron laser pulses.
Article in Nature communications, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
19 citing papers in PubMed.
- Pressure-Dependent Diffusion of PEG-Functionalized Gold Nanoparticles Probed by X-ray Photon Correlation Spectroscopy.The journal of physical chemistry. B · 2026Article
- A pipeline for megahertz X-ray photon correlation spectroscopy on soft matter samples at the MID instrument of European XFEL.Journal of synchrotron radiation · 2026Article
- Vesicle dynamics in synapsin-induced condensates by passive X-ray microrheology.Biophysical journal · 2026Article
- Nanofluidic-based electrochemical pump for remotely controlled, on-demand drug delivery.Lab on a chip · 2026Article
- Non-uniform interval-pulse X-ray photon correlation spectroscopy for reduced exposure.Journal of synchrotron radiation · 2026Article
- Lipoprotein diffusion in dense yolk plasma is governed by softness, hydrodynamics, and caging: Insights from MHz-XPCS.Proceedings of the National Academy of Sciences of the United States of America · 2026Article
- Coherent X-rays reveal anomalous molecular diffusion and cage effects in crowded protein solutions.Nature communications · 2025Article
- GRAMMCell: Docking-based Cell Modeling Resource.Journal of molecular biology · 2025Article
- Electrospinning and Nanofiber Technology: Fundamentals, Innovations, and Applications.Advanced materials (Deerfield Beach, Fla.) · 2025Review
- MHz X-ray photon correlation spectroscopy using an acoustic levitator at the European XFEL.Journal of synchrotron radiation · 2025Article
- Simulating Crowding In Vitro: Not an Elusive Goal Any Longer.Sub-cellular biochemistry · 2025Review
- Diffusion and Viscosity in Mixed Protein Solutions.The journal of physical chemistry. B · 2024Article
- On the analysis of two-time correlation functions: equilibrium versus non-equilibrium systems.Journal of applied crystallography · 2024Article
- Review
- Real-time swelling-collapse kinetics of nanogels driven by XFEL pulses.Science advances · 2024Article
- Lipid vesicle pools studied by passive X-ray microrheology.The European physical journal. E, Soft matter · 2023Article
- Exploring non-equilibrium processes and spatio-temporal scaling laws in heated egg yolk using coherent X-rays.Nature communications · 2023Article
- X-ray driven and intrinsic dynamics in protein gels.Scientific reports · 2023Article
- Coherent X-ray Scattering Reveals Nanoscale Fluctuations in Hydrated Proteins.The journal of physical chemistry. B · 2023Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
29 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
X-ray free-electron lasers (XFELs) with megahertz repetition rate can provide novel insights into structural dynamics of biological macromolecule solutions. However, very high dose rates can lead to beam-induced dynamics and structural changes due to radiation damage. Here, we probe the dynamics of dense antibody protein (Ig-PEG) solutions using megahertz X-ray photon correlation spectroscopy (MHz-XPCS) at the European XFEL. By varying the total dose and dose rate, we identify a regime for measuring the motion of proteins in their first coordination shell, quantify XFEL-induced effects such as driven motion, and map out the extent of agglomeration dynamics. The results indicate that for average dose rates below 1.06 kGy μs
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.