Evidence map›Paper›PMID 36130855›Full record

ReviewNeuromuscular disorders : NMD2022

SARS-CoV-2 vaccination and new-onset myasthenia gravis: A report of 7 cases and review of the literature.

Sithara Ramdas, Ryan Malcolm Hum, Abigail Price, Anna Paul, Jeremy Bland, Georgina Burke, Maria Farrugia, Jacqueline Palace, Alice Storrie, Pauline Ho and 3 more

Open access · greenAbstract readReviewCase Reports
In one paragraph

Review in Neuromuscular disorders : NMD, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
17citing papers in PubMed, 1 pooled it
3.5field-weighted citation impact, top 6% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

17 citing papers in PubMed, 1 synthesis or guideline pooled it, 28 citations in OpenAlex.

  1. Pooled it
  2. Article
  3. Article
  4. Review
  5. Autoimmune manifestations recorded after SARS-CoV-2 vaccination.Clinical and experimental vaccine research · 2025
    Article
  6. Article
  7. Article
  8. Article
  9. Article
  10. Article
  11. Autoimmune myasthenia gravis and COVID-19. A case report-based review.The Journal of international medical research · 2023
    Review
  12. Neuro-Ophthalmic Complications of COVID-19 Infection and Vaccination.Advances in ophthalmology and optometry · 2023
    Review
  13. Neurological Adverse Reactions to SARS-CoV-2 Vaccines.Clinical psychopharmacology and neuroscience : the official scientific journal of the Korean College of Neuropsychopharmacology · 2023
    Review
  14. Article
  15. COVID-19 Vaccination and Late-Onset Myasthenia Gravis: A New Case Report and Review of the Literature.International journal of environmental research and public health · 2022
    Review
  16. Article
  17. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

13 authors at 10 institutions in 1 country.

Sithara RamdasMDUK Neuromuscular Centre, Department of Paediatrics, University of Oxford, United Kingdom; Department of Paediatric Neurology, John Radcliffe Hospital, Oxford, United Kingdom.
Ryan Malcolm HumThe Kellgren Centre for Rheumatology, Manchester University NHS Foundation Trust, Manchester, United Kingdom; Centre for Musculoskeletal Research, Faculty of Biology, Medicine and Health, The University of Manchester, Manchester, United Kingdom.
Abigail PriceDepartment of Paediatrics, QEQM Hospital, Margate, United Kingdom.
Anna PaulDepartment of Paediatrics, QEQM Hospital, Margate, United Kingdom.
Jeremy BlandDepartment of Neurophysiology, East Kent University Hospitals NHS Foundation Trust, Kent, United Kingdom.
Georgina BurkeWessex Neurological Centre, Southampton General Hospital, Hampshire, United Kingdom.
Maria FarrugiaInstitute of Neurological Sciences, Queen Elizabeth University Hospital, Glasgow, United Kingdom.
Jacqueline PalaceNuffield Department of Clinical Neurosciences, University of Oxford, Oxford, United Kingdom.
Alice StorrieThe Kellgren Centre for Rheumatology, Manchester University NHS Foundation Trust, Manchester, United Kingdom.
Pauline HoThe Kellgren Centre for Rheumatology, Manchester University NHS Foundation Trust, Manchester, United Kingdom; Centre for Musculoskeletal Research, Faculty of Biology, Medicine and Health, The University of Manchester, Manchester, United Kingdom.
Emma StandingDepartment of Paediatric Neurology, Neuromuscular Service, Evelina's Children Hospital, Guy's & St. Thomas' Hospital NHS Foundation Trust, London, United Kingdom.
James B LillekerCentre for Musculoskeletal Research, Faculty of Biology, Medicine and Health, The University of Manchester, Manchester, United Kingdom; Manchester Centre for Clinical Neurosciences, Northern Care Alliance NHS Foundation Trust, Manchester, United Kingdom.
Heinz JungbluthDepartment of Paediatric Neurology, Neuromuscular Service, Evelina's Children Hospital, Guy's & St. Thomas' Hospital NHS Foundation Trust, London, United Kingdom; Randall Centre for Cell and Molecular Biophysics, Muscle Signalling Section, Faculty of Life Sciences and Medicine, King's College, London, United Kingdom. Electronic address: Heinz.Jungbluth@gstt.nhs.uk.
Manchester University NHS Foundation Trust · GBQueen Margaret's · GBEast Kent Hospitals University NHS Foundation Trust · GBGuy's and St Thomas' NHS Foundation Trust · GBJohn Radcliffe Hospital · GBManchester Academic Health Science Centre · GBQueen Elizabeth University Hospital · GBSouthampton General Hospital · GBSt Thomas' Hospital · GBUniversity of Oxford · GB

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Myasthenia gravis (MG) is an antibody-mediated immune disorder of the neuromuscular junction. SARS-CoV-2 is now recognised as a trigger factor for autoimmune diseases and to cause immune-mediated dysregulation, likely due to molecular mimicry induced by viral antigens. SARS-CoV-2 vaccination, similarly, results in exposure to viral antigen. Here we report 7 cases of new-onset myasthenia gravis in timely association with SARS-CoV-2 vaccination, including the first paediatric case identified to date. We also reviewed the literature for other new-onset MG cases reported within 4 weeks of SARS-CoV-2 vaccination and discuss our findings in the context of altered (auto)immunity following SARS-CoV-2 vaccination and/or infection.

Indexed as

COVID-19Myasthenia GravisChildCOVID-19 VaccinesHumansSARS-CoV-2VaccinationCOVID-19 VaccinesMyasthenia gravisSARS-CoV-2Vaccination

Identifiers

PMID36130855
PMCPMC9443923
OpenAlexW4294877897

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.