Evidence map›Paper›PMID 36130816›Full record

ArticleThe British journal of ophthalmology2023

Electroretinographic findings in retinal vasculitis.

Hashem H Ghoraba, Wataru Matsumiya, Christopher Or, Hassan Khojasteh, Prem Patel, Irmak Karaca, Jonathan Regenold, Moosa Zaidi, Jaclyn Hwang, Sherin Lajevardi and 8 more

Open access · greenAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in The British journal of ophthalmology, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
1.2field-weighted citation impact, top 23% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed, 6 citations in OpenAlex.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

18 authors at 2 institutions in 2 countries.

Hashem H GhorabaByers Eye Institute, Stanford University, Palo Alto, California, USA.ORCID 0000-0002-1145-4134
Wataru MatsumiyaByers Eye Institute, Stanford University, Palo Alto, California, USA.ORCID 0000-0003-3495-7460
Christopher OrByers Eye Institute, Stanford University, Palo Alto, California, USA.
Hassan KhojastehByers Eye Institute, Stanford University, Palo Alto, California, USA.
Prem PatelByers Eye Institute, Stanford University, Palo Alto, California, USA.
Irmak KaracaByers Eye Institute, Stanford University, Palo Alto, California, USA.ORCID 0000-0001-7927-0887
Jonathan RegenoldByers Eye Institute, Stanford University, Palo Alto, California, USA.
Moosa ZaidiByers Eye Institute, Stanford University, Palo Alto, California, USA.ORCID 0000-0003-1788-6306
Jaclyn HwangByers Eye Institute, Stanford University, Palo Alto, California, USA.
Sherin LajevardiByers Eye Institute, Stanford University, Palo Alto, California, USA.ORCID 0000-0002-7609-3827
Negin YavariByers Eye Institute, Stanford University, Palo Alto, California, USA.
Ngoc Trong Tuong ThanByers Eye Institute, Stanford University, Palo Alto, California, USA.
Sung Who ParkByers Eye Institute, Stanford University, Palo Alto, California, USA.
Amir AkhavanrezayatByers Eye Institute, Stanford University, Palo Alto, California, USA.
Gunay UludagByers Eye Institute, Stanford University, Palo Alto, California, USA.
Cigdem YasarByers Eye Institute, Stanford University, Palo Alto, California, USA.
Loh-Shan B LeungByers Eye Institute, Stanford University, Palo Alto, California, USA.ORCID 0000-0001-8496-0698
Quan Dong NguyenByers Eye Institute, Stanford University, Palo Alto, California, USA ndquan@stanford.edu.ORCID 0000-0001-9033-8117
Smith-Kettlewell Eye Research Institute · USStanford University · US

Funding

Stanford Vision Research CoreP30EY026877 · NEI · STANFORD UNIVERSITY · PI Jeffrey L Goldberg · 2017 to 2026
$8.0M
NEI NIH HHS P30 EY026877
6 · The paper itself

Abstract

aimTo describe and correlate electroretinographic responses with clinical and angiographic findings in retinal vasculitis (RV).

methodsMedical records of patients with diagnosis of RV at a tertiary eye centre from December 2017 to May 2021 were reviewed. Cases in which fluorescein angiography (FFA) and full field electroretinography (ffERG) were done within 1 month were included. FFAs were graded according to the Angiography Scoring for Uveitis Working Group from 0 to 40, where 0 is normal. A novel ffERG grading system was implemented where individual waves were graded for timing and amplitude and general ffERG score was determined with 6 being a perfect score.

results20 patients (34 eyes) were included. Mean age was 43.9±19.8 years; 70% were female. Median best-corrected visual acuity was 0.8 (0.08-1). Mean FFA score was 12.6±6.5. Median general ffERG score was 5 (0-6). 68% and 91% of eyes had responses with general ffERG scores ≥5 and 4, respectively. Flicker timing was most commonly affected.FFA scores weakly correlated with delayed photopic cone b-wave and flicker timing (p=0.03 and 0.016, respectively). Vitreous haze moderately correlated with delayed cone b-wave timing (p<0.001), delayed flicker timing (p=0.002) and weakly correlated with lower flicker amplitude (p=0.03). Underlying systemic disease was associated with poor ffERG responses.

conclusionIn this study, RV was not frequently associated with severe global retinal dysfunction Higher FFA scores, and vitreous haze grading were weakly, but significantly, correlated with cone-generated ffERG responses.

Indexed as

RetinaRetinal VasculitisAdultElectroretinographyFemaleFluorescein AngiographyHumansMaleMiddle AgedRetinal Cone Photoreceptor CellsYoung Adultelectrophysiologyinflammationretina

Identifiers

PMID36130816
PMCPMC10863994
OpenAlexW4296706153

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.