ArticleCell reports2022
Error correction and improved precision of spike timing in converging cortical networks.
Article in Cell reports, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers.
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Who cites it
8 citing papers in PubMed, 18 citations in OpenAlex.
- Contribution of spike timing to the neural code: from fast to slow timescales.Biological cybernetics · 2026Review
- Temporal resolution of spike coding in feedforward networks with signal convergence and divergence.PLoS computational biology · 2025Article
- Spike reliability is cell type specific and shapes excitation and inhibition in the cortex.Scientific reports · 2025Article
- Spike Reliability is Cell-Type Specific and Shapes Excitation and Inhibition in the Cortex.bioRxiv : the preprint server for biology · 2024Article
- Article
- Wired together, change together: Spike timing modifies transmission in converging assemblies.Science advances · 2024Article
- Short-term auditory priming in freely-moving mice.iScience · 2023Article
- Positive and biphasic extracellular waveforms correspond to return currents and axonal spikes.Communications biology · 2023Article
Corrections and comments
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Authors and funding
5 authors at 1 institution in 1 country.
Funding
Abstract
The brain propagates neuronal signals accurately and rapidly. Nevertheless, whether and how a pool of cortical neurons transmits an undistorted message to a target remains unclear. We apply optogenetic white noise signals to small assemblies of cortical pyramidal cells (PYRs) in freely moving mice. The directly activated PYRs exhibit a spike timing precision of several milliseconds. Instead of losing precision, interneurons driven via synaptic activation exhibit higher precision with respect to the white noise signal. Compared with directly activated PYRs, postsynaptic interneuron spike trains allow better signal reconstruction, demonstrating error correction. Data-driven modeling shows that nonlinear amplification of coincident spikes can generate error correction and improved precision. Over multiple applications of the same signal, postsynaptic interneuron spiking is most reliable at timescales ten times shorter than those of the presynaptic PYR, exhibiting temporal coding. Similar results are observed in hippocampal region CA1. Coincidence detection of convergent inputs enables messages to be precisely propagated between cortical PYRs and interneurons.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.