ArticlePlant physiology2022
Abscisic acid-responsive transcription factors PavDof2/6/15 mediate fruit softening in sweet cherry.
Article in Plant physiology, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 35 papers.
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35 citing papers in PubMed, 54 citations in OpenAlex.
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- Dynamic chromatin regulatory programs of sucrose and citric acid metabolism during fruit ripening in Citrus.The Plant cell · 2026Article
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- The MabZIP5-MaMYB69 module cooperates with MaERF55 to modulate banana fruit ripening via cell wall degradation.Horticulture research · 2026Article
- Identification of pivotal genes associated with sugar and organic acid metabolism during Prunus Mume fruit ripening via metabolomic and transcriptomic analyses.BMC plant biology · 2025Article
- Metabolomics Reveals Resistance-Related Secondary Metabolism in Sweet Cherry Infected byBiomolecules · 2025Article
- Investigation of the Jasmonate ZIM-Domain Family RevealsBiomolecules · 2025Article
- The PavDREB1E-PavD8-PavHY5 module integrates light and gibberellin signals to regulate sweet cherry anthocyanin biosynthesis.Plant physiology · 2025Article
- Identification of PpTHE1, a cell wall integrity sensor regulating the increased duration of harvest window in slow-melting flesh peach, through the assembly of a chromosome-level reference genome of Prunus persica.Plant biotechnology journal · 2025Article
- ERF100 regulated by ERF28 and NOR controls pectate lyase 7, modulating fig (Ficus carica L.) fruit softening.Plant biotechnology journal · 2025Article
- Enrichment of two important metabolites D-galacturonic acid and D-glucuronic acid inhibits MdHb1-mediated fruit softening in apple.Nature plants · 2025Article
- Comprehensive co-expression network reveals the fine-tuning of AsHSFA2c in balancing drought tolerance and growth in oat.Communications biology · 2025Article
- Comprehensive analysis of Dof transcription factors inFrontiers in plant science · 2025Article
- Genomes and integrative genomic insights into the genetic architecture of main agronomic traits in the edible cherries.Horticulture research · 2025Article
- Proteo-metabolomic analysis of fruits reveals molecular insights into variations among Italian Sweet Cherry (Frontiers in plant science · 2025Article
- Overexpression ofFrontiers in plant science · 2025Article
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12 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Softening is a key step during fruit ripening that is modulated by the interplay between multiple phytohormones. The antagonistic action of abscisic acid (ABA) and auxin determines the rate of fruit ripening and softening. However, the transcription factors that integrate ABA and auxin signals to regulate fruit softening remain to be determined. In this study, we identified several DNA-binding with One Finger (Dof) transcription factors essential for ABA-promoted fruit softening, based on transcriptome analysis of two sweet cherry (Prunus avium L.) varieties with different fruit firmness. We show that PavDof6 directly binds to the promoters of genes encoding cell wall-modifying enzymes to activate their transcription, while PavDof2/15 directly repress their transcription. Transient overexpression of PavDof6 and PavDof2/15 in sweet cherry fruits resulted in precocious and delayed softening, respectively. In addition, we show that the auxin response factor PavARF8, the expression of whose encoding gene is repressed by ABA, activates PavDof2/15 transcription. Furthermore, PavDof2/6/15 and PavARF8 directly bind to the 9-cis-epoxycarotenoid dioxygenase 1 (PavNCED1) promoter and regulate its expression, forming a feedback mechanism for ABA-mediated fruit softening. These findings unveil the physiological framework of fruit softening and establish a direct functional link between the ABA-PavARF8-PavDofs module and cell-wall-modifying genes in mediating fruit softening.
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