ArticleThe Plant cell2022
The type-B response regulators ARR10, ARR12, and ARR18 specify the central cell in Arabidopsis.
Article in The Plant cell, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. An erratum has been issued. Cited by 12 papers.
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Who cites it
12 citing papers in PubMed, 18 citations in OpenAlex.
- Molecular understanding of plant pollination, fertilization, seed development and protoplast regeneration.Science China. Life sciences · 2026Review
- A MAPK cascade regulates nuclear migration during female gametogenesis to establish specific cell identity and rice female fertility.Proceedings of the National Academy of Sciences of the United States of America · 2026Article
- Dissection of genomic regions underlying early seedling vigour in chickpea through genome-wide association mapping.BMC plant biology · 2025Article
- Genome-wide identification and expression analysis of the GARP superfamily in response to abiotic stresses in alfalfa (Medicago sativa L.).BMC plant biology · 2025Article
- Molecular Characterization of Cytokinin Response Regulator ARR21 inPlant direct · 2025Article
- Multi-omics analysis of organ-specific hormone distribution and molecular regulatory mechanisms inFrontiers in plant science · 2025Article
- The Role of Female and Male Genes in Regulating Pollen Tube Guidance in Flowering Plants.Genes · 2024Review
- Cytokinin: From autoclaved DNA to two-component signaling.The Plant cell · 2024Review
- From gametes to zygote: Mechanistic advances and emerging possibilities in plant reproduction.Plant physiology · 2024Review
- Gibberellin biosynthesis is required for CPPU-induced parthenocarpy in melon.Horticulture research · 2023Article
- CKI1-ARRs specify the central cell in Arabidopsis.The Plant cell · 2022Article
- Genome-wide identification and expression analysis of two-component system genes in sweet potato (Frontiers in plant science · 2022Article
Corrections and comments
- Erratum issued
Authors and funding
12 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
In Arabidopsis thaliana, the female gametophyte consists of two synergid cells, an egg cell, a diploid central cell, and three antipodal cells. CYTOKININ INDEPENDENT 1 (CKI1), a histidine kinase constitutively activating the cytokinin signaling pathway, specifies the central cell and restricts the egg cell. However, the mechanism regulating CKI1-dependent central cell specification is largely unknown. Here, we showed that the type-B ARABIDOPSIS RESPONSE REGULATORS10, 12, and 18 (ARR10/12/18) localize at the chalazal pole of the female gametophyte. Phenotypic analysis showed that the arr10 12 18 triple mutant is female sterile. We examined the expression patterns of embryo sac marker genes and found that the embryo sac of arr10 12 18 plants had lost central cell identity, a phenotype similar to that of the Arabidopsis cki1 mutant. Genetic analyses demonstrated that ARR10/12/18, CKI1, and ARABIDOPSIS HISTIDINE PHOSPHOTRANSFER PROTEIN2, 3, and 5 (AHP2/3/5) function in a common pathway to regulate female gametophyte development. In addition, constitutively activated ARR10/12/18 in the cki1 embryo sac partially restored the fertility of cki1. Results of transcriptomic analysis supported the conclusion that ARR10/12/18 and CKI1 function together to regulate the identity of the central cell. Our results demonstrated that ARR10/12/18 function downstream of CKI1-AHP2/3/5 as core factors to determine cell fate of the female gametophyte.
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