Evidence map›Paper›PMID 36130255›Full record

ArticleACS synthetic biology2022

Precise Genomic Riboregulator Control of Metabolic Flux in Microbial Systems.

Naresh Pandey, Steffi A Davison, Malathy Krishnamurthy, Daniel S Trettel, Chien-Chi Lo, Shawn Starkenburg, Katherine L Wozniak, Theresa L Kern, Sean D Reardon, Clifford J Unkefer and 2 more

Open access · greenAbstract read
In one paragraph

Article in ACS synthetic biology, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.

0numbers the graph read from it
0cells of the map it votes in
6citing papers in PubMed
0.4field-weighted citation impact, top 41% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

6 citing papers in PubMed, 6 citations in OpenAlex.

  1. Harnessing endophytes and Multi-Omics for sustainable Colchicine biosynthesis.World journal of microbiology & biotechnology · 2026
    Review
  2. Article
  3. Article
  4. Article
  5. Review
  6. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors at 1 institution in 1 country.

Naresh PandeyBioscience Division, Los Alamos National Laboratory, Los Alamos, New Mexico 87545, United States.
Steffi A DavisonBioscience Division, Los Alamos National Laboratory, Los Alamos, New Mexico 87545, United States.
Malathy KrishnamurthyBioscience Division, Los Alamos National Laboratory, Los Alamos, New Mexico 87545, United States.
Daniel S TrettelBioscience Division, Los Alamos National Laboratory, Los Alamos, New Mexico 87545, United States.
Chien-Chi LoBioscience Division, Los Alamos National Laboratory, Los Alamos, New Mexico 87545, United States.
Shawn StarkenburgBioscience Division, Los Alamos National Laboratory, Los Alamos, New Mexico 87545, United States.
Katherine L WozniakChemistry Division, Los Alamos National Laboratory, Los Alamos, New Mexico 87545, United States.
Theresa L KernBioscience Division, Los Alamos National Laboratory, Los Alamos, New Mexico 87545, United States.
Sean D ReardonBioscience Division, Los Alamos National Laboratory, Los Alamos, New Mexico 87545, United States.
Clifford J UnkeferBioscience Division, Los Alamos National Laboratory, Los Alamos, New Mexico 87545, United States.
Scott P HennellyBioscience Division, Los Alamos National Laboratory, Los Alamos, New Mexico 87545, United States.
Taraka DaleBioscience Division, Los Alamos National Laboratory, Los Alamos, New Mexico 87545, United States.
Los Alamos National Laboratory · US

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Engineered microbes can be used for producing value-added chemicals from renewable feedstocks, relieving the dependency on nonrenewable resources such as petroleum. These microbes often are composed of synthetic metabolic pathways; however, one major problem in establishing a synthetic pathway is the challenge of precisely controlling competing metabolic routes, some of which could be crucial for fitness and survival. While traditional gene deletion and/or coarse overexpression approaches do not provide precise regulation,

Indexed as

PetroleumPseudomonas putidaEscherichia coliGenomicsMetabolic EngineeringPhosphoenolpyruvatePyruvic AcidRNAPetroleumPhosphoenolpyruvatePyruvic AcidRNAcis,cis-muconatecis-repressorflow cytometrymetabolic engineeringPseudomonas putida KT2440riboregulatorRNA-based regulationsynthetic biology tools

Identifiers

PMID36130255
PMCPMC9594778
OpenAlexW4296949986

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.