ArticleJournal of immunology (Baltimore, Md. : 1950)2022
Akt-2 Is a Potential Therapeutic Target for Disseminated Candidiasis.
Ling Huang, Yilei Ma, Hui Guo, Na Tang, Song Ouyang, Patrick Nuro-Gyina, Lijian Tao, Yusen Liu, Matthew C O'Brien, Wallace Y Langdon and 1 more
Open access · bronzeAbstract read
In one paragraphArticle in Journal of immunology (Baltimore, Md. : 1950), 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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0citing papers in PubMed
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What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
2 · The registryThe trial behind it
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3 · Its place in the literatureWho cites it
0 citing papers in PubMed, 0 citations in OpenAlex.
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4 · The recordCorrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
5 · Who and what moneyAuthors and funding
11 authors at 6 institutions in 3 countries.
Ling HuangDepartment of Pathology, University of Iowa Roy J. and Lucille A. Carver College of Medicine, Iowa City, IA.
Yilei MaDepartment of Pathology, University of Iowa Roy J. and Lucille A. Carver College of Medicine, Iowa City, IA.
Hui GuoDepartment of Pathology, University of Iowa Roy J. and Lucille A. Carver College of Medicine, Iowa City, IA.
Na TangDepartment of Pathology, University of Iowa Roy J. and Lucille A. Carver College of Medicine, Iowa City, IA.
Song OuyangDepartment of Microbial Infection and Immunity, The Ohio State University, Columbus, OH.
Patrick Nuro-GyinaDepartment of Microbial Infection and Immunity, The Ohio State University, Columbus, OH.ORCID 0000-0002-2811-1533 Lijian TaoDepartment of Nephrology, Xiangya Hospital, Central South University, Changsha, Hunan, People's Republic of China.
Yusen LiuCenter for Perinatal Research, The Abigail Wexner Research Institute at Nationwide Children's Hospital, Columbus, OH.ORCID 0000-0002-0994-0109 Matthew C O'BrienDepartment of Pathology, University of Iowa Roy J. and Lucille A. Carver College of Medicine, Iowa City, IA.
Wallace Y LangdonSchool of Biomedical Sciences, University of Western Australia, Perth, WA, Australia.ORCID 0000-0001-7783-4423 Jian ZhangDepartment of Pathology, University of Iowa Roy J. and Lucille A. Carver College of Medicine, Iowa City, IA; jian-zhang@uiowa.edu.ORCID 0000-0002-9523-5296 University of Iowa · USCentral South University · CNNationwide Children's Hospital · USThe First Hospital of Changsha · CNThe Ohio State University · USThe University of Western Australia · AU
Funding
TRAINING IN MECHANISMS OF PARASITISMT32AI007511 · NIAID · UNIVERSITY OF IOWA · PI BUTLER, NOAH SULLIVAN, WEBER, MARY · 1996 to 2025
$8.1MNEDD4 IN T HELPER CELL DEVELOPMENT AND AUTOIMMUNITYR01AI090901 · NIAID · UNIVERSITY OF IOWA · PI WALDSCHMIDT, THOMAS J · 2010 to 2020
$4.0MRegulation of Innate Immune System Sensing of C. Albicans InfectionsR01AI123253 · NIAID · UNIVERSITY OF IOWA · PI WALDSCHMIDT, THOMAS J · 2016 to 2020
$2.1MRegulation and Function of Mkp-1 During Sepsis.R01AI124029 · NIAID · RESEARCH INST NATIONWIDE CHILDREN'S HOSP · PI LIU, YUSEN · 2017 to 2021
$1.9MRole of Protein Ubiquitination in SepsisR01AI121196 · NIAID · UNIVERSITY OF IOWA · PI ZHANG, JIAN · 2016 to 2020
$1.7MMkp-1 suppresses immune checkpoint protein PD-L1 to prevent sepsis-associated immune dysfunction and mortalityR21AI142885 · NIAID · RESEARCH INST NATIONWIDE CHILDREN'S HOSP · PI LIU, YUSEN · 2019 to 2020
$418kNIAID NIH HHS R01 AI090901NIAID NIH HHS R01 AI121196NIAID NIH HHS R01 AI123253NIAID NIH HHS R01 AI124029NIAID NIH HHS R21 AI142885NIAID NIH HHS T32 AI007511
6 · The paper itselfAbstract
Akt-1 and Akt-2 are the major isoforms of the serine/threonine Akt family that play a key role in controlling immune responses. However, the involvement of Akt-1 and Akt-2 isoforms in antifungal innate immunity is completely unknown. In this study, we show that
Indexed as
Candida albicansCandidiasisAnimalsAntifungal AgentsMiceMice, Inbred C57BLNeutrophilsPeroxidaseProto-Oncogene Proteins c-aktReactive Oxygen SpeciesSerineThreonineAkt2 protein, mouseAntifungal AgentsPeroxidaseProto-Oncogene Proteins c-aktReactive Oxygen SpeciesSerineThreonine
Identifiers
PMID36130126
PMCPMC11141526
OpenAlexW4296794670
What OpenQuestion holds
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