ArticleCerebral cortex (New York, N.Y. : 1991)2023
A middle ground where executive control meets semantics: the neural substrates of semantic control are topographically sandwiched between the multiple-demand and default-mode systems.
Article in Cerebral cortex (New York, N.Y. : 1991), 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 30 papers.
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Who cites it
30 citing papers in PubMed.
- Model-based semantic distance reveals adaptive coordination of distinct cognitive systems in flexible knowledge retrieval.Nature communications · 2026Article
- Structure-function dynamics in healthy cognitive aging: a graph signal processing approach.Brain structure & function · 2026Article
- Concept Cells and the Neural Bases of Human Memory.Acta physiologica (Oxford, England) · 2026Review
- The Neural Processes Underpinning Flexible Semantic Retrieval in Visual and Auditory Modalities.Human brain mapping · 2026Article
- Prefrontal and Cerebellar Contributions to Semantic Memory Retrieval.Neurobiology of language (Cambridge, Mass.) · 2026Article
- Functional differentiation and interactions among inferior, medial frontal and posterior temporal cortex in semantic control.Communications biology · 2025Article
- Altered white matter microstructure of language pathways and semantic cognition deficiencies in early psychosis.Schizophrenia (Heidelberg, Germany) · 2025Article
- Causal contributions of left inferior and medial frontal cortex to semantic and executive control.Communications biology · 2025Article
- The inferior fronto-occipital fasciculus: bridging phylogeny, ontogeny and functional anatomy.Brain : a journal of neurology · 2025Review
- The Dimensionality of Neural Coding for Cognitive Control Is Gradually Transformed within the Lateral Prefrontal Cortex.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2025Article
- What we mean when we say semantic: Toward a multidisciplinary semantic glossary.Psychonomic bulletin & review · 2025Review
- Lifespan oscillatory dynamics in lexical production: A population-based MEG resting-state analysis.Imaging neuroscience (Cambridge, Mass.) · 2025Article
- Mapping the task-general and task-specific neural correlates of speech production: Meta-analysis and fMRI direct comparisons of category fluency and picture naming.Imaging neuroscience (Cambridge, Mass.) · 2025Article
- Inhibition of the inferior parietal lobe triggers state-dependent network adaptations.Heliyon · 2024Article
- Spatiotemporal Neural Network for Sublexical Information Processing: An Intracranial SEEG Study.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2024Article
- Macroscale brain states support the control of semantic cognition.Communications biology · 2024Article
- The Brain's Topographical Organization Shapes Dynamic Interaction Patterns That Support Flexible Behavior Based on Rules and Long-Term Knowledge.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2024Article
- Distinctive and Complementary Roles of Default Mode Network Subsystems in Semantic Cognition.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2024Article
- Default mode network shows distinct emotional and contextual responses yet common effects of retrieval demands across tasks.Human brain mapping · 2024Article
- Measuring semantic memory using associative and dissociative retrieval tasks.Royal Society open science · 2024Article
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5 authors.
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Abstract
Semantic control is the capability to operate on meaningful representations, selectively focusing on certain aspects of meaning while purposefully ignoring other aspects based on one's behavioral aim. This ability is especially vital for comprehending figurative/ambiguous language. It remains unclear why and how regions involved in semantic control seem reliably juxtaposed alongside other functionally specialized regions in the association cortex, prompting speculation about the relationship between topography and function. We investigated this issue by characterizing how semantic control regions topographically relate to the default-mode network (associated with memory and abstract cognition) and multiple-demand network (associated with executive control). Topographically, we established that semantic control areas were sandwiched by the default-mode and multi-demand networks, forming an orderly arrangement observed both at the individual and group level. Functionally, semantic control regions exhibited "hybrid" responses, fusing generic preferences for cognitively demanding operation (multiple-demand) and for meaningful representations (default-mode) into a domain-specific preference for difficult operation on meaningful representations. When projected onto the principal gradient of human connectome, the neural activity of semantic control showed a robustly dissociable trajectory from visuospatial control, implying different roles in the functional transition from sensation to cognition. We discuss why the hybrid functional profile of semantic control regions might result from their intermediate topographical positions on the cortex.
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