ArticleThe Plant cell2022
Genetic variation underlying differential ammonium and nitrate responses in Arabidopsis thaliana.
Article in The Plant cell, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers.
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Who cites it
14 citing papers in PubMed, 22 citations in OpenAlex.
- Plasticity of metabolism in plants.The Plant journal : for cell and molecular biology · 2026Review
- HHO5 orchestrates dose-dependent feedback regulation of organic versus inorganic nitrogen signaling in Arabidopsis.The Plant cell · 2026Article
- Root system architecture modulates nitrogen uptake and use efficiency, influencing grain yield in rice.Scientific reports · 2026Article
- Functional insights into dispensable genes using genome-wide loss-of-function burden tests in Arabidopsis.The Plant cell · 2026Article
- Natural variation in the adjustment of primary metabolism determines ammonium tolerance in the model grass Brachypodium distachyon.Journal of experimental botany · 2024Article
- Natural variation in response to combined water and nitrogen deficiencies in Arabidopsis.The Plant cell · 2024Article
- Integration of shoot-derived polypeptide signals by root TGA transcription factors is essential for survival under fluctuating nitrogen environments.Nature communications · 2024Article
- A persistent major mutation in canonical jasmonate signaling is embedded in an herbivory-elicited gene network.Proceedings of the National Academy of Sciences of the United States of America · 2023Article
- Integrated comparative transcriptome and physiological analysis reveals the metabolic responses underlying genotype variations in NHFrontiers in plant science · 2023Article
- Determination of optimal NHFrontiers in plant science · 2023Article
- Breeding for Higher Yields of Wheat and Rice through Modifying Nitrogen Metabolism.Plants (Basel, Switzerland) · 2022Review
- Mapping the genomic basis of developmental and metabolic responses to nitrogen.The Plant cell · 2022Article
- Abolishing ANAC017-Mediated Mitochondria Retrograde Signalling Alleviates Ammonium Toxicity in Arabidopsis thaliana.Physiologia plantarumArticle
- Novel method for the quantification of rosette area from images ofApplications in plant sciencesArticle
Corrections and comments
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Authors and funding
10 authors at 2 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Nitrogen is an essential element required for plant growth and productivity. Understanding the mechanisms and natural genetic variation underlying nitrogen use in plants will facilitate the engineering of plant nitrogen use to maximize crop productivity while minimizing environmental costs. To understand the scope of natural variation that may influence nitrogen use, we grew 1,135 Arabidopsis thaliana natural genotypes on two nitrogen sources, nitrate and ammonium, and measured both developmental and defense metabolite traits. By using different environments and focusing on multiple traits, we identified a wide array of different nitrogen responses. These responses are associated with numerous genes, most of which were not previously associated with nitrogen responses. Only a small portion of these genes appear to be shared between environments or traits, while most are predominantly specific to a developmental or defense trait under a specific nitrogen source. Finally, by using a large population, we were able to identify unique nitrogen responses, such as preferring ammonium or nitrate, which appear to be generated by combinations of loci rather than a few large-effect loci. This suggests that it may be possible to obtain novel phenotypes in complex nitrogen responses by manipulating sets of genes with small effects rather than solely focusing on large-effect single gene manipulations.
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