Evidence map›Paper›PMID 36130057›Full record

Trial reportJournal of the National Cancer Institute2023

Improving biobehavioral health in younger breast cancer survivors: Pathways to Wellness trial secondary outcomes.

Julienne E Bower, Ann H Partridge, Antonio C Wolff, Steve W Cole, Michael R Irwin, Elissa D Thorner, Hadine Joffe, Laura Petersen, Catherine M Crespi, Patricia A Ganz

Registry-linked trialOpen access · bronzeAbstract readRandomized Controlled Trial
PubMed Full text at PMC Publisher
In one paragraph

Trial report in Journal of the National Cancer Institute, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT03025139 (Improving Outcomes for Younger Breast Cancer Survivors), which is not on this map. Cited by 10 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
10citing papers in PubMed, 1 pooled it
1.2field-weighted citation impact, top 20% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT03025139 naunknown statusnot on this map

Improving Outcomes for Younger Breast Cancer Survivors: A Phase III Randomized Trial Targeting Behavioral Symptoms in Younger Breast Cancer Survivors

TypeinterventionalSponsorJonsson Comprehensive Cancer CenterRan2017 to 2024Enrolled96ConditionsCancer Survivor, Early-Stage Breast Carcinoma, Stage 0 Breast Cancer, Stage IA Breast CancerArmsEducational Intervention, Laboratory Biomarker Analysis, Meditation Therapy, Questionnaire Administration
3 · Its place in the literature

Who cites it

10 citing papers in PubMed, 1 synthesis or guideline pooled it, 12 citations in OpenAlex.

  1. Management of Fatigue in Adult Survivors of Cancer: ASCO-Society for Integrative Oncology Guideline Update.Journal of clinical oncology : official journal of the American Society of Clinical Oncology · 2024
    Guideline
  2. Trial
  3. Review
  4. Review
  5. Observational
  6. Article
  7. Review
  8. Article
  9. Review
  10. Psychosocial and supportive care concerns of young women living with advanced breast cancer: baseline findings from a prospective virtual support intervention study.Supportive care in cancer : official journal of the Multinational Association of Supportive Care in Cancer · 2024
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors at 4 institutions in 1 country.

Julienne E BowerDepartment of Psychology, University of California, Los Angeles, Los Angeles, CA, USA.ORCID 0000-0003-0813-4444
Ann H PartridgeDepartment of Medical Oncology, Dana Farber Cancer Institute, Boston, MA, USA.
Antonio C WolffThe Johns Hopkins University School of Medicine and Sidney Kimmel Comprehensive Cancer Center, Baltimore, MD, USA.
Steve W ColeDepartment of Psychiatry and Biobehavioral Sciences, David Geffen School of Medicine, University of California, Los Angeles, Los Angeles, CA, USA.
Michael R IrwinDepartment of Psychology, University of California, Los Angeles, Los Angeles, CA, USA.
Elissa D ThornerThe Johns Hopkins University School of Medicine and Sidney Kimmel Comprehensive Cancer Center, Baltimore, MD, USA.
Hadine JoffeConnors Center for Women's Health and Gender Biology, Brigham and Women's Hospital, Harvard Medical School, Boston, MA, USA.ORCID 0000-0002-7035-8249
Laura PetersenJonsson Comprehensive Cancer Center, University of California, Los Angeles, Los Angeles, CA, USA.ORCID 0000-0002-4843-2692
Catherine M CrespiJonsson Comprehensive Cancer Center, University of California, Los Angeles, Los Angeles, CA, USA.
Patricia A GanzJonsson Comprehensive Cancer Center, University of California, Los Angeles, Los Angeles, CA, USA.
Salk Institute for Biological Studies · USUniversity of California, Los Angeles · USBrigham and Women's Hospital · USJohns Hopkins University · US

Funding

Translational Research Central ServicesP30CA006973 · NCI · JOHNS HOPKINS UNIVERSITY · PI Rosalie Wollett · 1985 to 2026
$208.6M
Women's CancersP30CA016042 · NCI · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI Samuel Wheeler French · 1985 to 2026
$134.5M
UCLA Clinical Translational Science InstituteUL1TR001881 · NCATS · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI ARLEEN F. BROWN, ARASH NAEIM · 2016 to 2026
$118.1M
A Phase III Randomized Trial Targeting Behavioral Symptoms in Younger Breast Cancer SurvivorsR01CA200977 · NCI · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI BOWER, JULIENNE E, GANZ, PATRICIA A. · 2016 to 2020
$3.2M
NCATS NIH HHS UL1 TR001881NCI NIH HHS P30 CA006973NCI NIH HHS P30 CA016042NCI NIH HHS R01 CA200977NIH HHS R01 CA200977NIH HHS UL1TR001881Susan G. Komen SAC 170001
6 · The paper itself

Abstract

backgroundThe Pathways to Wellness trial tested the efficacy of 2 interventions for younger breast cancer survivors: mindful awareness practices (MAPs) and survivorship education (SE). This planned secondary analysis examines intervention effects on stress, positive psychological outcomes, and inflammation (Clincaltrials.gov NCT03025139).

methodsWomen diagnosed with breast cancer at or before age 50 years who had completed treatment and had elevated depressive symptoms were randomly assigned to 6 weeks of MAPs, SE, or wait-list control (WLC). Assessments conducted at pre- and postintervention and at 3- and 6-month follow-up measured general stress perceptions, cancer-related intrusive thoughts and worry, positive affect, meaning and peace in life, altruism and empathy, and markers of inflammation. Analyses compared change in outcomes over time in each intervention group relative to WLC using linear mixed models.

resultsA total 247 women were randomly assigned to MAPs (n = 85), SE (n = 81), or WLC (n = 81). MAPs statistically significantly decreased intrusive thoughts and worry at postintervention and 3-month follow-up relative to WLC (P < .027) and statistically significantly increased positive affect and meaning and peace at postintervention, with positive affect persisting at 3-month follow-up (P < .027). SE statistically significantly decreased intrusive thoughts at 3-month follow-up and statistically significantly increased positive affect at 6-month follow-up relative to WLC (P < .01). Proinflammatory gene expression increased in WLC relative to MAPs (P = .016) but did not differ from SE. There were no intervention effects on other outcomes.

conclusionMAPs had beneficial effects on psychological and immune outcomes in younger breast cancer survivors and is a promising approach for enhancing biobehavioral health.

Indexed as

Breast NeoplasmsCancer SurvivorsCognitionFemaleHumansInflammationMiddle Aged

Identifiers

PMID36130057
PMCPMC9830488
OpenAlexW4296932860

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.