ArticleScience translational medicine2022
Receptor-independent fluid-phase macropinocytosis promotes arterial foam cell formation and atherosclerosis.
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Article in Science translational medicine, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 28 papers.
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28citing papers in PubMed
3.1field-weighted citation impact, top 7% of its field
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28 citing papers in PubMed, 41 citations in OpenAlex.
- Myeloid Cell-Specific Deletion of LGR4 Suppresses Atherosclerotic Lesion Formation.Arteriosclerosis, thrombosis, and vascular biology · 2026Article
- Mechanistic Insights into Redox-Dependent Macropinocytosis in Primary Human Neutrophils.Antioxidants (Basel, Switzerland) · 2026Article
- Toll-like receptor 4 signaling links cytoskeletal remodeling to lipid accumulation in macrophages.Inflammation and regeneration · 2026Review
- A foam cell-targeted lipophagy restoration strategy stabilizes vulnerable atherosclerotic plaques.Bioactive materials · 2026Article
- New insights into outer membrane vesicles in Gram-negative bacteria from biogenesis to applications.Communications biology · 2026Review
- Macropinocytosis inhibition attenuates profibrotic responses in lung fibroblasts and pulmonary fibrosis models.The Journal of clinical investigation · 2026Article
- IL-6 triggers lysosomal degradation of LDL-R and enhances LDL-C uptake in vascular endothelial cells via macropinocytosis.Molecular medicine (Cambridge, Mass.) · 2026Article
- Anti-Atherogenic Actions of Pomegranate Polyphenol Punicalagin and Its Metabolites: In Vitro Effects on Vascular Cells and In Vivo Atheroprotection by Urolithin A via Anti-Inflammatory and Plaque-Stabilising Mechanisms.Antioxidants (Basel, Switzerland) · 2026Article
- Tirzepatide mitigates atherosclerosis progression and modulates oxLDL-mediated proatherogenic effects in macrophages: evidence for M1/M2 homeostasis restoration.Archives of pharmacal research · 2026Article
- Macrophage FTO deficiency accelerates atherosclerosis via PACS2-mediated activation of the PPARγ lipid signaling pathway.Journal of translational medicine · 2026Article
- Liver sinusoidal endothelial cells constitute a major route for hemoglobin clearance.EMBO reports · 2026Article
- The cardiovascular-immune axis: crosstalk and therapy in atherosclerosis, myocarditis and vasculitis.Frontiers in immunology · 2026Review
- The CD47 signaling axis regulates the formation and vulnerability of atherosclerotic plaques: mechanism analysis and targeting strategies.Frontiers in immunology · 2026Review
- NHE1 in macrophages promotes octanal/Olfr2-induced atherosclerosis via calcium-dependent ROS and NLRP3 inflammasome activation.Scientific reports · 2025Article
- Targeting autophagy in dysfunctional tumor vasculature.iScience · 2025Review
- Role of Matricellular Proteins in Endothelial Cell Inflammation and Atherosclerosis.Antioxidants (Basel, Switzerland) · 2025Review
- Metabolites in the extracellular tumor microenvironment and the shaping of macrophage function.Molecular cell · 2025Review
- Vascular Smooth Muscle Cells: A Therapeutic Target in Atherosclerosis.Reviews in cardiovascular medicine · 2025Review
- Regulatory roles of PIWI-interacting RNAs in cardiovascular disease.American journal of physiology. Heart and circulatory physiology · 2025Review
- Recombinant high-density lipoprotein targeted delivery of celastrol to promote foam cells lipophagy against early atherosclerosis.Journal of nanobiotechnology · 2025Article
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Authors and funding
19 authors at 3 institutions in 2 countries.
Hui-Ping LinVascular Biology Center, Medical College of Georgia, Augusta University, Augusta, GA 30912, USA.ORCID 0000-0002-3136-9543
Bhupesh SinglaVascular Biology Center, Medical College of Georgia, Augusta University, Augusta, GA 30912, USA.ORCID 0000-0003-2752-6849
WonMo AhnVascular Biology Center, Medical College of Georgia, Augusta University, Augusta, GA 30912, USA.ORCID 0000-0001-9735-8022
Pushpankur GhoshalVascular Biology Center, Medical College of Georgia, Augusta University, Augusta, GA 30912, USA.ORCID 0000-0003-0233-4701
Maria BlahoveVascular Biology Center, Medical College of Georgia, Augusta University, Augusta, GA 30912, USA.ORCID 0000-0002-9022-7801
Mary Cherian-ShawVascular Biology Center, Medical College of Georgia, Augusta University, Augusta, GA 30912, USA.ORCID 0000-0002-8079-6453
Alex ChenVascular Biology Center, Medical College of Georgia, Augusta University, Augusta, GA 30912, USA.ORCID 0000-0001-5662-8188
April HallerCenter for Lipid and Arteriosclerosis Science, Department of Pathology and Laboratory Medicine, University of Cincinnati, Cincinnati, OH 45237, USA.ORCID 0000-0002-0560-3033
David Y HuiCenter for Lipid and Arteriosclerosis Science, Department of Pathology and Laboratory Medicine, University of Cincinnati, Cincinnati, OH 45237, USA.ORCID 0000-0001-7333-2151
Kunzhe DongDepartment of Pharmacology and Toxicology, Medical College of Georgia, Augusta University, Augusta, GA 30912, USA.ORCID 0000-0003-0039-9835
Jiliang ZhouDepartment of Pharmacology and Toxicology, Medical College of Georgia, Augusta University, Augusta, GA 30912, USA.ORCID 0000-0002-2375-4636
Joseph WhiteDepartment of Pathology, Medical College of Georgia, Augusta University, Augusta, GA 30912, USA.ORCID 0000-0003-0289-686X
Alexis M StranahanDepartment of Neuroscience and Regenerative Medicine, Medical College of Georgia, Augusta University, Augusta, GA 30912, USA.ORCID 0000-0003-0612-2837
Agnieszka JasztalJagiellonian Centre for Experimental Therapeutics (JCET), Jagiellonian University, Bobrzynskiego 14, 30-348 Krakow, Poland.ORCID 0000-0002-5790-1059
Rudolf LucasVascular Biology Center, Medical College of Georgia, Augusta University, Augusta, GA 30912, USA.ORCID 0000-0003-3805-8868
Brian K StansfieldVascular Biology Center, Medical College of Georgia, Augusta University, Augusta, GA 30912, USA.ORCID 0000-0002-1105-8895
David FultonVascular Biology Center, Medical College of Georgia, Augusta University, Augusta, GA 30912, USA.ORCID 0000-0002-1528-1517
Stefan ChlopickiJagiellonian Centre for Experimental Therapeutics (JCET), Jagiellonian University, Bobrzynskiego 14, 30-348 Krakow, Poland.ORCID 0000-0002-2878-3858
Gábor CsányiVascular Biology Center, Medical College of Georgia, Augusta University, Augusta, GA 30912, USA.ORCID 0000-0002-4429-3031
Augusta University · USJagiellonian University · PLUniversity of Cincinnati · US
Funding
Inflammation and retinopathy of prematurityR01EY029318 · NEI · AUGUSTA UNIVERSITY · PI STANSFIELD, BRIAN KEVIN · 2019 to 2023
$2.2MENaC-α mediates lung fluid clearance and capillary barrier function in pneumoniaR01HL138410 · NHLBI · AUGUSTA UNIVERSITY · PI LUCAS, RUDOLF · 2018 to 2021
$2.0MLipid macropinocytosis: a novel target in atherosclerotic cardiovascular diseaseR01HL139562 · NHLBI · AUGUSTA UNIVERSITY · PI CSANYI, GABOR · 2018 to 2022
$1.9MA Novel Role of Macrophage TSP1-CD47 Signaling in AtherosclerosisR00HL114648 · NHLBI · AUGUSTA UNIVERSITY · PI CSANYI, GABOR · 2015 to 2017
$747kRegulation of Lymphangiogenesis by Thrombospondin 1R00HL146954 · NHLBI · UNIVERSITY OF TENNESSEE HEALTH SCI CTR · PI SINGLA, BHUPESH · 2022 to 2024
$739kRegulation of Lymphangiogenesis by Thrombospondin 1K99HL146954 · NHLBI · AUGUSTA UNIVERSITY · PI SINGLA, BHUPESH · 2020 to 2021
$232kMechanisms of foamy monocyte formation in atherosclerosisF31HL162498 · NHLBI · AUGUSTA UNIVERSITY · PI AHN, WONMO · 2022 to 2024
$105kNEI NIH HHS R01 EY029318NHLBI NIH HHS F31 HL162498NHLBI NIH HHS K99 HL146954NHLBI NIH HHS R00 HL114648NHLBI NIH HHS R00 HL146954NHLBI NIH HHS R01 HL138410NHLBI NIH HHS R01 HL139562
Abstract
Accumulation of lipid-laden foam cells in the arterial wall plays a central role in atherosclerotic lesion development, plaque progression, and late-stage complications of atherosclerosis. However, there are still fundamental gaps in our knowledge of the underlying mechanisms leading to foam cell formation in atherosclerotic arteries. Here, we investigated the role of receptor-independent macropinocytosis in arterial lipid accumulation and pathogenesis of atherosclerosis. Genetic inhibition of fluid-phase macropinocytosis in myeloid cells (
Indexed as
AtherosclerosisFoam CellsAnimalsApolipoproteins EArteriesCD36 AntigensHumansLipoproteins, LDLMiceMice, KnockoutApolipoproteins ECD36 AntigensLipoproteins, LDL
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