ArticleScience translational medicine2022
Molecular MRI quantification of extracellular aldehyde pairs for early detection of liver fibrogenesis and response to treatment.
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Article in Science translational medicine, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 21 papers.
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21citing papers in PubMed
5.6field-weighted citation impact, top 3% of its field
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Who cites it
21 citing papers in PubMed, 37 citations in OpenAlex.
- Early detection of invasive lung cancer and multiorgan metastasis by a collagen-targeted protein MRI contrast agent.Science advances · 2026Article
- A modular protein-nucleic acid nanodevice for non-genetic engineering of mesenchymal stem cells to target pathological collagen in liver fibrosis.Journal of nanobiotechnology · 2026Article
- Molecular Imaging Probes for Early Detection and Staging of Liver Fibrosis.Chemical & biomedical imaging · 2025Review
- Article
- Manganese-based type I collagen-targeting MRI probe for in vivo imaging of liver fibrosis.Npj imaging · 2025Article
- FAP-catalyzed in situ self-assembly of magnetic resonance imaging probe for early and precise staging of liver fibrosis.Science advances · 2025Article
- Non-invasive diagnosis of liver fibrosis via MRI using targeted gadolinium-based nanoparticles.European journal of nuclear medicine and molecular imaging · 2024Article
- Quantitative in Vivo Molecular MRI.Advanced materials (Deerfield Beach, Fla.) · 2024Review
- A FAPα-activated MRI nanoprobe for precise grading diagnosis of clinical liver fibrosis.Nature communications · 2024Article
- Smart Microneedle Arrays Integrating Cell-Free Therapy and Nanocatalysis to Treat Liver Fibrosis.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2024Article
- Allysine-Targeted Molecular MRI Enables Early Prediction of Chemotherapy Response in Pancreatic Cancer.Cancer research · 2024Article
- Simultaneous Positron Emission Tomography and Molecular Magnetic Resonance Imaging of Cardiopulmonary Fibrosis in a Mouse Model of Left Ventricular Dysfunction.Journal of the American Heart Association · 2024Article
- Dynamics of collagen oxidation and cross linking in regenerating and irreversibly infarcted myocardium.Nature communications · 2024Article
- Nitric oxide regulation of fetal and newborn lung development and function.Nitric oxide : biology and chemistry · 2024Review
- Molecular Imaging of Fibrosis in Benign Diseases: An Overview of the State of the Art.Pharmaceuticals (Basel, Switzerland) · 2024Review
- Late-Stage Functionalization of Living Organisms: Rethinking Selectivity in Biology.Chemical reviews · 2024Review
- Advances in Noninvasive Molecular Imaging Probes for Liver Fibrosis Diagnosis.Biomaterials research · 2024Review
- Found in translation-Fibrosis in metabolic dysfunction-associated steatohepatitis (MASH).Science translational medicine · 2023Review
- Optimization of an Allysine-Targeted PET Probe for Quantifying Fibrogenesis in a Mouse Model of Pulmonary Fibrosis.Molecular imaging and biology · 2023Article
- Tailored Chemical Reactivity Probes for Systemic Imaging of Aldehydes in Fibroproliferative Diseases.Journal of the American Chemical Society · 2023Article
Corrections and comments
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Authors and funding
14 authors at 4 institutions in 1 country.
Yingying NingAthinoula A. Martinos Center for Biomedical Imaging, Institute for Innovation in Imaging, Department of Radiology, Massachusetts General Hospital and Harvard Medical School, Boston, MA 02129, USA.ORCID 0000-0002-2942-2202
Iris Y ZhouAthinoula A. Martinos Center for Biomedical Imaging, Institute for Innovation in Imaging, Department of Radiology, Massachusetts General Hospital and Harvard Medical School, Boston, MA 02129, USA.ORCID 0000-0002-4351-7398
Jesse D RobertsCardiovascular Research Center of the General Medical Services, Massachusetts General Hospital and Harvard Medical School, Boston, MA 02129, USA.ORCID 0000-0003-0271-275X
Nicholas J RotileAthinoula A. Martinos Center for Biomedical Imaging, Institute for Innovation in Imaging, Department of Radiology, Massachusetts General Hospital and Harvard Medical School, Boston, MA 02129, USA.ORCID 0000-0001-6568-9927
Eman AkamAthinoula A. Martinos Center for Biomedical Imaging, Institute for Innovation in Imaging, Department of Radiology, Massachusetts General Hospital and Harvard Medical School, Boston, MA 02129, USA.ORCID 0000-0003-2544-5762
Stephen C BarrettDivision of Gastrointestinal and Oncologic Surgery, Massachusetts General Hospital and Harvard Medical School, Boston, MA 02114, USA.ORCID 0000-0002-8764-2027
Mozhdeh SojoodiDivision of Gastrointestinal and Oncologic Surgery, Massachusetts General Hospital and Harvard Medical School, Boston, MA 02114, USA.ORCID 0000-0002-9946-5910
Matthew N BarrDepartment of Earth Sciences, Dartmouth College, Hanover, NH 03766, USA.
Tracy PunshonDepartment of Earth Sciences, Dartmouth College, Hanover, NH 03766, USA.
Pamela PantazopoulosAthinoula A. Martinos Center for Biomedical Imaging, Institute for Innovation in Imaging, Department of Radiology, Massachusetts General Hospital and Harvard Medical School, Boston, MA 02129, USA.
Hannah K DrescherGastrointestinal Unit, Massachusetts General Hospital and Harvard Medical School, Boston, MA 02114, USA.ORCID 0000-0001-9945-1239
Brian P JacksonDepartment of Earth Sciences, Dartmouth College, Hanover, NH 03766, USA.ORCID 0000-0003-2311-2972
Kenneth K TanabeDivision of Gastrointestinal and Oncologic Surgery, Massachusetts General Hospital and Harvard Medical School, Boston, MA 02114, USA.
Peter CaravanAthinoula A. Martinos Center for Biomedical Imaging, Institute for Innovation in Imaging, Department of Radiology, Massachusetts General Hospital and Harvard Medical School, Boston, MA 02129, USA.ORCID 0000-0002-3179-6537
Athinoula A. Martinos Center for Biomedical Imaging · USMassachusetts General Hospital · USDartmouth College · USHarvard University · US
Funding
Translational Engineering in Cancer (TEC)P30CA023108 · NCI · DARTMOUTH COLLEGE · PI Fred W Kolling IV · 1985 to 2026
$91.3MMolecular MR Imaging of Hepatic FibrogenesisR01DK121789 · NIDDK · MASSACHUSETTS GENERAL HOSPITAL · PI Peter D Caravan · 2019 to 2026
$5.0MLaying the Groundwork for Web-based Elemental Imaging Software: The MicroAnalysis ToolkitR24GM141194 · NIGMS · DARTMOUTH COLLEGE · PI Brian P Jackson · 2021 to 2026
$3.1MCarbon-13 Polarizer for Metabolic MR ImagingS10OD021768 · OD · MASSACHUSETTS GENERAL HOSPITAL · PI YEN, YI-FEN · 2017 to 2017
$1.9MTGFB and Nitric Oxide Signaling in Pediatric Pulmonary Vascular DiseaseR01HL125715 · NHLBI · MASSACHUSETTS GENERAL HOSPITAL · PI ROBERTS, JESSE D · 2015 to 2018
$1.7MQuantitative MRI-PET Imaging of Pulmonary FibrosisK25HL148837 · NHLBI · MASSACHUSETTS GENERAL HOSPITAL · PI ZHOU, IRIS YUWEN · 2020 to 2023
$686kElectronics Upgrade for 11.7 TS10OD025234 · OD · MASSACHUSETTS GENERAL HOSPITAL · PI CARAVAN, PETER D · 2018 to 2018
$595kTGFB AND PULMONARY ALDEHYDES IN NEWBORN LUNG INJURYR56HL147863 · NHLBI · MASSACHUSETTS GENERAL HOSPITAL · PI ROBERTS, JESSE D · 2019 to 2019
$425kHPLC-ICP-MS SystemS10OD010650 · OD · MASSACHUSETTS GENERAL HOSPITAL · PI CARAVAN, PETER D · 2013 to 2013
$371kNCI NIH HHS P30 CA023108NHLBI NIH HHS K25 HL148837NHLBI NIH HHS R01 HL125715NHLBI NIH HHS R56 HL147863NIDDK NIH HHS R01 DK121789NIGMS NIH HHS R24 GM141194NIH HHS S10 OD010650NIH HHS S10 OD021768NIH HHS S10 OD025234
Abstract
Liver fibrosis plays a critical role in the evolution of most chronic liver diseases and is characterized by a buildup of extracellular matrix, which can progress to cirrhosis, hepatocellular carcinoma, liver failure, or death. Now, there are no noninvasive methods available to accurately assess disease activity (fibrogenesis) to sensitively detect early onset of fibrosis or to detect early response to treatment. Here, we hypothesized that extracellular allysine aldehyde (Lys
Indexed as
AldehydesLiverAnimalsBiomarkersCollagenFibrosisHumansLiver CirrhosisMagnetic Resonance ImagingMiceMolecular ProbesRatsAldehydesBiomarkersCollagenMolecular Probes
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