ArticlePloS one2022
Numerical study of magnetic hyperthermia ablation of breast tumor on an anatomically realistic breast phantom.
Article in PloS one, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers.
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11 citing papers in PubMed, 32 citations in OpenAlex.
- How do vibration stimulation frequencies affect the nonlinear dynamics and mechanical characterization of breast cancer cells?Biochemistry and biophysics reports · 2026Article
- Multiphysical Characterization of a Tissue-Mimicking Phantom: Composition, Thermal Behavior, and Broadband Electromagnetic Properties from Visible to Terahertz and Microwave Frequencies.Materials (Basel, Switzerland) · 2026Article
- A comprehensive modeling on thermal damage in tumor hyperthermia therapies using magneto-plasmonic nanocomposite.Scientific reports · 2025Article
- 3D Computational Modeling of FeNanotechnology, science and applications · 2025Article
- A Review of Electromagnetic Fields in Cellular Interactions and Cacao Bean Fermentation.Foods (Basel, Switzerland) · 2024Review
- Model based deep learning method for focused ultrasound pathway scanning.Scientific reports · 2024Article
- Article
- Tumor-targeting cell membrane-coated nanorings for magnetic-hyperthermia-induced tumor ablation.Biomaterials science · 2023Article
- A 3D Approach Using a Control Algorithm to Minimize the Effects on the Healthy Tissue in the Hyperthermia for Cancer Treatment.Entropy (Basel, Switzerland) · 2023Article
- Non-Surgical Definitive Treatment for Operable Breast Cancer: Current Status and Future Prospects.Cancers · 2023Review
- Numerical Estimation of SAR and Temperature Distributions inside Differently Shaped Female Breast Tumors during Radio-Frequency Ablation.Materials (Basel, Switzerland) · 2022Article
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2 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Magnetic fluid hyperthermia (MFH) is a novel reliable technique with excellent potential for thermal therapies and treating breast tumours. This method involves injecting a magnetic nanofluid into the tumour and applying an external AC magnetic field to induce heat in the magnetic nanoparticles (MNPs) and raise the tumour temperature to ablation temperature ranges. Because of the complexity of considering and coupling all different physics involves in this phenomenon and also due to the intricacy of a thorough FEM numerical study, few FEM-based studies address the entire MFH process as similar to reality as possible. The current study investigates a FEM-based three-dimensional numerical simulation of MFH of breast tumours as a multi-physics problem. An anatomically realistic breast phantom (ARBP) is considered, some magnetic nanofluid is injected inside the tumour, and the diffusion phenomenon is simulated. Then, the amount of heat generated in the MNP-saturated tumour area due to an external AC magnetic field is simulated. In the end, the fraction of tumour tissue necrotized by this temperature rise is evaluated. The study's results demonstrate that by injecting nanofluid and utilizing seven circular copper windings with each coil carrying 400 A current with a frequency of 400 kHz for generating the external AC magnetic field, the temperature in tumour tissue can be raised to a maximum of about 51.4°C, which leads to necrosis of entire tumour tissue after 30 minutes of electromagnetic field (EMF) exposure. This numerical platform can depict all four various physics involved in the MFH of breast tumours by numerically solving all different equation sets coupled together with high precision. Thus, the proposed model can be utilized by clinicians as a reliable tool for predicting and identifying the approximate amount of temperature rise and the necrotic fraction of breast tumour, which can be very useful to opt for the best MFH therapeutic procedure and conditions based on various patients. In future works, this numerical platform's results should be compared with experimental in-vivo results to improve and modify this platform in order to be ready for clinical applications.
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