ArticlePLoS genetics2022
Long-distance transport of sucrose in source leaves promotes sink root growth by the EIN3-SUC2 module.
Article in PLoS genetics, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers.
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Who cites it
19 citing papers in PubMed, 39 citations in OpenAlex.
- The loss of COP1 delays senescence and inhibits root growth through modulation of sucrose allocation and availability.Plant physiology · 2026Article
- Reducing recalcitrance of black pepper toHorticulture research · 2026Article
- Article
- Regulatory DNA Sequences Controlling Gene Expression in Leaf Phloem Cells.Methods in molecular biology (Clifton, N.J.) · 2026Review
- Limited phosphate resources are efficiently allocated to each organ by the PHR1-EIN3/EIL1 module to coordinate their establishment.Science advances · 2025Article
- RsWRKY40 coordinates the cold stress response by integrating RsSPS1-mediated sucrose accumulation and the CBF-dependent pathway in radish (Raphanus sativus L.).Molecular horticulture · 2025Article
- Crosstalk Between Ethylene and JA/ABA/Sugar Signalling in Plants Under Physiological and Stress Conditions.Molecular plant pathology · 2025Review
- Trichome development of systemic developing leaves is regulated by a nutrient sensor-relay mechanism within mature leaves.Science advances · 2025Article
- Sugar transporters: mediators of carbon flow between plants and microbes.Frontiers in plant science · 2025Review
- RAPID ALKALINIZATION FACTOR 22 is a key modulator of the root hair growth responses to fungal ethylene emissions in Arabidopsis.Plant physiology · 2024Article
- The critical roles of three sugar-related proteins (HXK, SnRK1, TOR) in regulating plant growth and stress responses.Horticulture research · 2024Article
- Maize multi-omics reveal leaf water status controlling of differential transcriptomes, proteomes and hormones as mechanisms of age-dependent osmotic stress response in leaves.Stress biology · 2024Article
- Drought stress tolerance and metabolomics ofFrontiers in plant science · 2024Article
- The Sink-Source Relationship in Cucumber (Plants (Basel, Switzerland) · 2023Article
- Vacuolar Sugar Transporter TMT2 Plays Crucial Roles in Germination and Seedling Development in Arabidopsis.International journal of molecular sciences · 2023Article
- Circadian regulation of metabolism across photosynthetic organisms.The Plant journal : for cell and molecular biology · 2023Review
- Integrating Transcriptional, Metabolic, and Physiological Responses to Drought Stress inPlants (Basel, Switzerland) · 2023Article
- Signalling and regulation of plant development by carbon/nitrogen balance.Physiologia plantarumReview
- Impact of the Simultaneous Loss of the Plastid Envelope-Localized Homologous Pair Ycf10 and DLDG1 in Plant Growth and Photosynthetic Performance.Physiologia plantarumArticle
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Authors and funding
10 authors at 4 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
In most plants, sucrose, a major storage sugar, is transported into sink organs to support their growth. This key physiological process is dependent on the function of sucrose transporters. Sucrose export from source tissues is predominantly controlled through the activity of SUCROSE TRANSPORTER 2 (SUC2), required for the loading of sucrose into the phloem of Arabidopsis plants. However, how SUC2 activity is controlled to support root growth remains unclear. Glucose is perceived via the function of HEXOKINASE 1 (HXK1), the only known nuclear glucose sensor. HXK1 negatively regulates the stability of ETHYLENE-INSENSITIVE3 (EIN3), a key ethylene/glucose interaction component. Here we show that HXK1 functions upstream of EIN3 in the regulation of root sink growth mediated by glucose signaling. Furthermore, the transcription factor EIN3 directly inhibits SUC2 activity by binding to the SUC2 promoter, regulating glucose signaling linked to root sink growth. We demonstrate that these molecular components form a HXK1-EIN3-SUC2 module integral to the control of root sink growth. Also, we demonstrate that with increasing age, the HXK1-EIN3-SUC2 module promotes sucrose phloem loading in source tissues thereby elevating sucrose levels in sink roots. As a result, glucose signaling mediated-sink root growth is facilitated. Our findings thus establish a direct molecular link between the HXK1-EIN3-SUC2 module, the source-to sink transport of sucrose and root growth.
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