Evidence map›Paper›PMID 36129776›Full record

ArticleMolecular biology of the cell2022

Membrane fusion by

Daniel Crosby, Tina H Lee

Abstract read
In one paragraph

Article in Molecular biology of the cell, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

5 citing papers in PubMed.

  1. Review
  2. Article
  3. Article
  4. The atlastin paralogs: The complexity in the tails.The Journal of cell biology · 2023
    Article
  5. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

2 authors.

Daniel CrosbyDepartment of Biological Sciences, Carnegie Mellon University, Pittsburgh, PA 15213.
Tina H LeeDepartment of Biological Sciences, Carnegie Mellon University, Pittsburgh, PA 15213.ORCID 0000-0002-2610-6204

Funding

Mechanism and Role of Membrane Fusion by the Atlastin GTPase - Equipment SupplementR01GM107285 · NIGMS · CARNEGIE-MELLON UNIVERSITY · PI LEE, CHRISTINA H · 2014 to 2025
$2.9M
NIGMS NIH HHS R01 GM107285
6 · The paper itself

Abstract

Atlastin (ATL) GTPases undergo trans dimerization and a power strokelike crossover conformational rearrangement to drive endoplasmic reticulum membrane fusion. Fusion depends on GTP, but the role of nucleotide hydrolysis has remained controversial. For instance, nonhydrolyzable GTP analogs block fusion altogether, suggesting a requirement for GTP hydrolysis in ATL dimerization and crossover, but this leaves unanswered the question of how the ATL dimer is disassembled after fusion. We recently used the truncated cytoplasmic domain of wild-type

Indexed as

DrosophilaMembrane FusionAnimalsEndoplasmic ReticulumGuanosine TriphosphateHydrolysisMembrane ProteinsModels, MolecularGuanosine TriphosphateMembrane Proteins

Identifiers

PMID36129776
PMCPMC9727788

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-SA
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.