ArticleMolecular biology of the cell2022
Cell segregation via differential collision modes between heterotypic cell populations.
Article in Molecular biology of the cell, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
6 citing papers in PubMed, 11 citations in OpenAlex.
- Partial EMT Drives Persistent Collective Migration via Collision Guidance in Heterogeneous Populations.bioRxiv : the preprint server for biology · 2026Article
- Organoid bioprinting to pattern the matrix microenvironment.Current opinion in biomedical engineering · 2025Article
- Friction in soft biological systems and surface self-organization: the role of viscoelasticity.Biophysical reviews · 2024Review
- Role of viscoelasticity in the appearance of low-Reynolds turbulence: considerations for modelling.Journal of biological engineering · 2024Review
- Topological data analysis of spatial patterning in heterogeneous cell populations: clustering and sorting with varying cell-cell adhesion.NPJ systems biology and applications · 2023Article
- Independent control over cell patterning and adhesion on hydrogel substrates for tissue interface mechanobiology.iScience · 2023Article
Corrections and comments
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Authors and funding
3 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
In tissue development and regeneration, the establishment of sharp boundaries between heterotypic cells is essential for the differentiation of tissue functions. During the dynamic rearrangements of constituent cells that result from cell division and collective migration, the segregation boundary encounters various challenges. Several studies have suggested that cortical actomyosin structures play a crucial role in the maintenance of the boundary interface of segregated cell populations, implicating actin-mediated stresses. Examining physical cellular properties such as motility, traction, and intercellular stress, we investigated the formation and maintenance of the stable segregation between epithelial and mesenchymal cell populations devoid of heterotypic adhesions. At the contact boundary, the homotypic adhesion-mediated epithelial aggregates exerted collision-mediated compression against the surrounding mesenchymal cells. Our results demonstrated that heterotypic cell populations established a robust interfacial boundary by accumulating stress from active collisions and repulsions between two dissimilar cell types. Furthermore, the moment of the heterotypic collisions was identified by the existence of a sharp rise in maximum shear stress within the cell cluster.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.