Evidence map›Paper›PMID 36129619›Full record

ArticleCancer causes & control : CCC2022

Racial differences in anthropometric measures as risk factors for triple-negative breast cancer.

Fengge Wang, Candyce H Kroenke, Kathy Pan, Aladdin H Shadyab, Rowan T Chlebowski, Jean Wactawski-Wende, Lihong Qi, Juhua Luo

Open access · greenAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Cancer causes & control : CCC, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed, 1 pooled it
0.4field-weighted citation impact, top 36% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed, 1 synthesis or guideline pooled it, 4 citations in OpenAlex.

  1. Pooled it
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 5 institutions in 1 country.

Fengge WangDepartment of Epidemiology and Biostatistics, School of Public Health, Indiana University, Bloomington, IN, USA. fw1@iu.edu.ORCID http://orcid.org/0000-0001-9568-9418
Candyce H KroenkeDivision of Research, Kaiser Permanente Northern California, Oakland, CA, USA.
Kathy PanDepartment of Hematology/Oncology, Kaiser Permanente Southern California, Bellflower, CA, USA.
Aladdin H ShadyabHerbert Wertheim School of Public Health and Human Longevity Science, University of California, San Diego, La Jolla, CA, USA.
Rowan T ChlebowskiThe Lundquist Institute, Torrance, CA, USA.
Jean Wactawski-WendeDepartment of Epidemiology and Environmental Health, School of Public Health and Health Professions, University at Buffalo, Buffalo, NY, USA.
Lihong QiDepartment of Public Health Science, School of Medicine, University of California, Davis, Davis, CA, USA.
Juhua LuoDepartment of Epidemiology and Biostatistics, School of Public Health, Indiana University, Bloomington, IN, USA.
Indiana University Bloomington · USKaiser Permanente · USUniversity at Buffalo, State University of New York · USUniversity of California, Davis · USUniversity of California San Diego · US

Funding

Women's Health Initiative Cancer Survivor CohortUM1CA173642 · NCI · FRED HUTCHINSON CANCER RESEARCH CENTER · PI ANDERSON, GARNET L., CAAN, BETTE J · 2013 to 2018
$12.1M
Social networks and disparities in health behaviors and breast cancer outcomes in immigrant womenR01CA230440 · NCI · KAISER FOUNDATION RESEARCH INSTITUTE · PI KROENKE, CANDYCE H · 2019 to 2024
$3.2M
An Electronic Health Record-Based Tool to Identify Newly Diagnosed Breast Cancer Patients at Risk of Low Social SupportR01CA253028 · NCI · KAISER FOUNDATION RESEARCH INSTITUTE · PI KROENKE, CANDYCE H · 2020 to 2025
$2.6M
WOMENS HEALTH INITIATIVE-N01WH22110N01WH022110 · WH · FRED HUTCHINSON CANCER RESEARCH CENTER · PI ROSS, PRENTICE · 1992 to 2006
$1.2M
NCI NIH HHS R01 CA230440NCI NIH HHS R01 CA253028NCI NIH HHS UM1 CA173642WHI NIH HHS N01 WH022110
6 · The paper itself

Abstract

purposeThe incidence of triple-negative breast cancer (TNBC) is higher in Black women compared to White women which is not explained by racial differences in body mass index (BMI). As BMI has limitations as an anthropometric measure, we used different anthropometric measures to examine associations with TNBC by race.

methodOf 161,808 postmenopausal participants in Women's Health Initiative, eligible were a subsample of 121,744 White and Black postmenopausal women enrolled from 1993 to 1998, 50-79 years of age with anthropometric measures who were followed for breast cancer incidence until March 2019. At entry, BMI, waist circumference (WC), and waist-hip ratio (WHR) were measured using standardized methods. Breast cancers were verified by central medical record review. Associations between anthropometric measures and triple-negative breast cancer risk were examined using Cox proportional hazards regression models.

resultsAfter 17.6 years (median) follow-up, there were 87 Black women and 529 White women with incident triple-negative breast cancer. Overall, there were no significant associations between anthropometric measures and risk of triple-negative breast cancer. However, compared to White women with normal BMI, White women with obesity (BMI ≥ 30) (HR 0.76, 95% CI 0.60, 0.96) were significantly associated with a lower risk of triple-negative breast cancer. And larger waist circumference (HR per centimeter 0.99, 95% CI 0.99, 1.00) was significantly associated with a lower risk of triple-negative breast cancer among White women.

conclusionOverall, among postmenopausal women, anthropometric measures were not associated with risk of TNBC. The association among White women with larger waist circumference and women with obesity with a lower risk of triple-negative breast cancer needs further confirmation.

Indexed as

Triple Negative Breast NeoplasmsBody Mass IndexFemaleHumansObesityPostmenopauseProspective StudiesRace FactorsRisk FactorsWaist CircumferenceWaist-Hip RatioBMIRacial disparityTriple-negative breast cancerWaistWaist-to-hip ratio

Identifiers

PMID36129619
PMCPMC10257496
OpenAlexW4296964334

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.