Evidence map›Paper›PMID 36129552›Full record

ArticleAnnals of biomedical engineering2023

Adaptation of Fibril-Reinforced Poroviscoelastic Properties in Rabbit Collateral Ligaments 8 Weeks After Anterior Cruciate Ligament Transection.

Gustavo A Orozco, Aapo Ristaniemi, Mehrnoush Haghighatnejad, Ali Mohammadi, Mikko A J Finnilä, Simo Saarakkala, Walter Herzog, Hanna Isaksson, Rami K Korhonen

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In one paragraph

Article in Annals of biomedical engineering, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
0.7field-weighted citation impact, top 30% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed, 4 citations in OpenAlex.

  1. Article
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 5 institutions in 4 countries.

Gustavo A OrozcoDepartment of Applied Physics, University of Eastern Finland, Yliopistonranta 1, 70210, Kuopio, Finland. gustavo.orozco@bme.lth.se.ORCID http://orcid.org/0000-0002-1054-7937
Aapo RistaniemiDepartment of Applied Physics, University of Eastern Finland, Yliopistonranta 1, 70210, Kuopio, Finland.ORCID http://orcid.org/0000-0002-0909-5099
Mehrnoush HaghighatnejadDepartment of Applied Physics, University of Eastern Finland, Yliopistonranta 1, 70210, Kuopio, Finland.
Ali MohammadiDepartment of Applied Physics, University of Eastern Finland, Yliopistonranta 1, 70210, Kuopio, Finland.ORCID http://orcid.org/0000-0001-6254-0879
Mikko A J FinniläResearch Unit of Medical Imaging, Physics and Technology, University of Oulu, Oulu, Finland.ORCID http://orcid.org/0000-0002-3348-5759
Simo SaarakkalaResearch Unit of Medical Imaging, Physics and Technology, University of Oulu, Oulu, Finland.ORCID http://orcid.org/0000-0003-2850-5484
Walter HerzogHuman Performance Laboratory, Faculty of Kinesiology, University of Calgary, Calgary, Canada.ORCID http://orcid.org/0000-0002-5341-0033
Hanna IsakssonDepartment of Biomedical Engineering, Lund University, Box 188, 221 00, Lund, Sweden.ORCID http://orcid.org/0000-0002-9690-8907
Rami K KorhonenDepartment of Applied Physics, University of Eastern Finland, Yliopistonranta 1, 70210, Kuopio, Finland.ORCID http://orcid.org/0000-0002-3486-7855
University of Eastern Finland · FILund University · SEOulu University Hospital · FIUniversity of Calgary · CAUniversity of Oulu · FI

Funding

Academy of Finland 324529Academy of Finland 334773 - under the frame of ERA PerMed)The Arthritis Society, Canada, SOG-10-0521Vetenskapsrådet 2019-00953 - under the frame of ERA PerMed
6 · The paper itself

Abstract

Ligaments of the knee provide stability and prevent excessive motions of the joint. Rupture of the anterior cruciate ligament (ACL), a common sports injury, results in an altered loading environment for other tissues in the joint, likely leading to their mechanical adaptation. In the collateral ligaments, the patterns and mechanisms of biomechanical adaptation following ACL transection (ACLT) remain unknown. We aimed to characterize the adaptation of elastic and viscoelastic properties of the lateral and medial collateral ligaments eight weeks after ACLT. Unilateral ACLT was performed in six rabbits, and collateral ligaments were harvested from transected and contralateral knee joints after eight weeks, and from an intact control group (eight knees from four animals). The cross-sectional areas were measured with micro-computed tomography. Stepwise tensile stress-relaxation testing was conducted up to 6% final strain, and the elastic and viscoelastic properties were characterized with a fibril-reinforced poroviscoelastic material model. We found that the cross-sectional area of the collateral ligaments in the ACL transected knees increased, the nonlinear elastic collagen network modulus of the LCL decreased, and the amount of fast relaxation in the MCL decreased. Our results indicate that rupture of the ACL leads to an early adaptation of the elastic and viscoelastic properties of the collagen fibrillar network in the collateral ligaments. These adaptations may be important to consider when evaluating whole knee joint mechanics after ACL rupture, and the results aid in understanding the consequences of ACL rupture on other tissues.

Indexed as

Anterior Cruciate Ligament InjuriesCollateral LigamentsAnimalsAnterior Cruciate LigamentBiomechanical PhenomenaCollagenKnee JointRabbitsX-Ray MicrotomographyCollagenAnterior cruciate ligament transectionFinite element modelMedial/lateral collateral ligamentRabbit modelTissue adaptation

Identifiers

PMID36129552
PMCPMC10023629
OpenAlexW4296551132

What OpenQuestion holds

Textfull text, public
LicenceCC BY
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Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.