Evidence map›Paper›PMID 36129535›Full record

Trial reportEuropean journal of pediatrics2022

The effect of placental transfusion on hemodynamics in premature newborns: a randomized controlled trial.

Marwa Mohamed Farag, Mohamed Alaa Eldin Hassan Thabet, Ali Mohamed Abd-Almohsen, Heba Idris Abudeif Mohammed Ibrahim

Registry-linked trialOpen access · hybridAbstract readRandomized Controlled Trial
PubMed Full text at PMC Publisher
In one paragraph

Trial report in European journal of pediatrics, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT04811872 (Evaluation of the Effect of Placental Transfusion on Hemodynamics in Premature Newborns), which is not on this map. Cited by 8 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
8citing papers in PubMed, 1 pooled it
1.1field-weighted citation impact, top 22% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT04811872 phase2 / phase3completednot on this map

Evaluation of the Effect of Placental Transfusion on Hemodynamics in Premature Newborns

TypeinterventionalSponsorMarwa Mohamed FaragRan2021 to 2021Enrolled57ConditionsPre-TermArmsIntact umbilical cord milking (I-UCM), Cut-umbilical cord milking(C-UCM), Delayed Cord Clamping (DCC)
3 · Its place in the literature

Who cites it

8 citing papers in PubMed, 1 synthesis or guideline pooled it, 7 citations in OpenAlex.

  1. Pooled it
  2. Trial
  3. Trial
  4. Trial
  5. Article
  6. Observational
  7. Article
  8. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors at 1 institution in 1 country.

Marwa Mohamed FaragPediatric Department, Alexandria University, Alexandria, Egypt. d.marwa.farag@gmail.com.ORCID http://orcid.org/0000-0003-0426-9018
Mohamed Alaa Eldin Hassan ThabetPediatric Department, Alexandria University, Alexandria, Egypt.
Ali Mohamed Abd-AlmohsenPediatric Department, Alexandria University, Alexandria, Egypt.
Heba Idris Abudeif Mohammed IbrahimPediatric Department, Alexandria University, Alexandria, Egypt.
Alexandria University · EG

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Despite of growing evidence of the beneficial effects of placental transfusion techniques, there is no available sufficient data about their effects on vulnerable hemodynamics and myocardium of premature infants. The purpose of this work is to study ventricular functions and hemodynamics after applying different placental transfusion techniques, delayed cord clamping (DCC), cut cord milking (C-UCM), and intact cord milking (I-UCM). Sixty-four infants delivered whether by C-section or vaginal delivery were randomly assigned to undergo C-UCM (20-30 cm), I-UCM (3-4 strippings), and DCC (30-60 s). Functional echocardiography was done on day 1 and day 3 of life for 57 infants. Primary outcome variable was superior vena cava flow measurement in infants having placental transfusion in the first 24 h of life and between 64 and 72 h. Secondary outcomes were other echocardiographic and clinical hemodynamic parameters, and biventricular functions in those infants. Of a total 196 preterm infants ≤ 32 weeks delivered in the study period, from January 2021 to August 2021, 57 infants were eligible and survived till the second examination. They were randomly assigned to the three groups. Neonates randomly assigned to DCC had significantly higher superior vena cava flow and lower right ventricular systolic function in the first 24 h of life. This finding vanished at day 3. Neonates undergone different methods of placental transfusions had similar hemoglobin, admission temperature, and mean blood pressure in the first 24 h of life.

conclusionDespite their potential benefits, placental transfusions have shown to alter the hemodynamics and adversely affect myocardial function of premature neonates.

trial registrationThis trial was registered in the clinical trial gov NCT04811872. WHAT IS KNOWN: • Placental transfusion techniques might have benefits regarding prematurity- related morbidities and mortality. WHAT IS NEW: • Placental transfusion might adversely affect the myocardium and alter hemodynamics in premature infants.

Indexed as

Infant, PrematureInfant, Premature, DiseasesConstrictionFemaleHemodynamicsHumansInfantInfant, NewbornPlacentaPregnancyUmbilical CordUmbilical Cord ClampingVena Cava, SuperiorCord milkingDelayed cord clampingFractional shorteningSuperior vena cava flow

Identifiers

PMID36129535
PMCPMC9649456
OpenAlexW4296962005

What OpenQuestion holds

Textmetadata
LicenceCC BY
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Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.