Evidence map›Paper›PMID 36129491›Full record

ArticlePsychopharmacology2023

The role of dorsomedial striatum adenosine 2A receptors in the loss of goal-directed behaviour.

Jaec A Emtage, Megan L Shipman, Laura H Corbit

Abstract read
PubMed Publisher
In one paragraph

Article in Psychopharmacology, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
0.5field-weighted citation impact, top 43% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed, 5 citations in OpenAlex.

  1. Review
  2. Review
  3. Article
  4. Striatopallidal adenosine ANeuropharmacology · 2023
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors at 1 institution in 1 country.

Jaec A EmtageDepartment of Cell and Systems Biology, University of Toronto, 25 Harbord Street, Toronto, ON, M5S 3G5, Canada.
Megan L ShipmanDepartment of Psychology, University of Toronto, 100 St. George Street, Toronto, ON, M5S 3G3, Canada.
Laura H CorbitDepartment of Cell and Systems Biology, University of Toronto, 25 Harbord Street, Toronto, ON, M5S 3G5, Canada. laura.corbit@utoronto.ca.ORCID http://orcid.org/0000-0002-8356-0999
University of Toronto · CA

Funding

CIHR 404315
6 · The paper itself

Abstract

rationaleAdenosine A

objectivesTo examine the effects of the adenosine A

methodsMale rats were trained to lever press for food reward. The A

resultsIntra-DMS administration of CGS-21680 impaired sensitivity to outcome devaluation. CGS-21680 treatment did not impair acquisition of specific response-outcome associations, selective control of responding based on the presence of stimuli that signaled when reward was or was not available, discrimination between stimuli or lever choices nor did it influence the effect of devaluation on the amounts of food eaten in a consumption test.

conclusionsCGS-21680 impairs the ability to modulate responding based on recent changes to outcome value, an effect that is not accounted for by impairments in behavioural inhibition, discrimination, encoding the specific outcome of a response or the effectiveness of specific satiety.

Indexed as

Conditioning, OperantGoalsAdenosineAnimalsCorpus StriatumMaleNeostriatumRatsAdenosineAdenosineCGS-21680DevaluationDorsomedial striatumGoal-directed behaviourInhibitionOperantStimulus

Identifiers

PMID36129491
OpenAlexW4296964445

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.