Evidence map›Paper›PMID 36129480›Full record

ReviewInternational urogynecology journal2023

Hiatal failure: effects of pregnancy, delivery, and pelvic floor disorders on level III factors.

Wenjin Cheng, Emily English, Whitney Horner, Carolyn W Swenson, Luyun Chen, Fernanda Pipitone, James A Ashton-Miller, John O L DeLancey

Abstract readReview
In one paragraph

Review in International urogynecology journal, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers.

0numbers the graph read from it
0cells of the map it votes in
19citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

19 citing papers in PubMed.

  1. Article
  2. Review
  3. Article
  4. Article
  5. Article
  6. Chapter 4.5: New Proposed Treatments for Pelvic Organ Prolapse.International urogynecology journal · 2026
    Review
  7. Article
  8. Article
  9. Article
  10. Article
  11. Article
  12. Article
  13. Up for the tackle? The pelvic floor and rugby. A review.European journal of sport science · 2024
    Review
  14. Article
  15. Review
  16. Review
  17. Article
  18. Review
  19. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Wenjin ChengDepartment of Obstetrics and Gynecology, University of Michigan, Ann Arbor, MI, USA. wenjinc525@yahoo.com.ORCID http://orcid.org/0000-0003-1465-5887
Emily EnglishDepartment of Obstetrics and Gynecology, University of Michigan, Ann Arbor, MI, USA.
Whitney HornerDepartment of Obstetrics and Gynecology, University of Michigan, Ann Arbor, MI, USA.
Carolyn W SwensonDepartment of Obstetrics and Gynecology, University of Michigan, Ann Arbor, MI, USA.
Luyun ChenDepartment of Obstetrics and Gynecology, University of Michigan, Ann Arbor, MI, USA.
Fernanda PipitoneDepartment of Obstetrics and Gynecology, University of Michigan, Ann Arbor, MI, USA.
James A Ashton-MillerDepartment of Biomedical Engineering, University of Michigan, Ann Arbor, MI, USA.
John O L DeLanceyDepartment of Obstetrics and Gynecology, University of Michigan, Ann Arbor, MI, USA.

Funding

Research Education CoreP30AG024824 · NIA · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI Neil Alexander · 2004 to 2026
$29.2M
Development of 21st Century Concepts and Tools for Quantifying Urethral Failure Mechanisms that Cause Urinary IncontinenceRC2DK122379 · NIDDK · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI ASHTON-MILLER, JAMES ANTHONY, DELANCEY, JOHN O.L. · 2019 to 2024
$5.7M
Using a mechanistic classification scheme to identify the causes of anterior vaginal wall prolapse and develop a validated surgical planning systemR01HD094954 · NICHD · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI CHEN, LUYUN · 2018 to 2020
$935k
NIA NIH HHS P30 AG024824NICHD NIH HHS R01 HD094954NIDDK NIH HHS RC2 DK122379
6 · The paper itself

Abstract

introduction and hypothesisThe failure of the levator hiatus (LH) and urogenital hiatus (UGH) to remain closed is not only associated with pelvic floor disorders, but also contributes to recurrence after surgical repair. Pregnancy and vaginal birth are key events affecting this closure. An understanding of normal and failed hiatal closure is necessary to understand, manage, and prevent pelvic floor disorders.

methodsThis narrative review was conducted by applying the keywords "levator hiatus" OR "genital hiatus" OR "urogenital hiatus" in PubMed. Articles that reported hiatal size related to pelvic floor disorders and pregnancy were chosen. Weighted averages for hiatal size were calculated for each clinical situation.

resultsWomen with prolapse have a 22% and 30% larger LH area measured by ultrasound at rest and during Valsalva than parous women with normal support. Women with persistently enlarged UGH have 2-3 times higher postoperative failure rates after surgery for prolapse. During pregnancy, the LH area at Valsalva increases by 29% from the first to the third trimester in preparation for childbirth. The enlarged postpartum hiatus recovers over time, but does not return to nulliparous size after vaginal birth. Levator muscle injury during vaginal birth, especially forceps-assisted, is associated with increases in hiatal size; however, it only explains a portion of hiatus variation-the rest can be explained by pelvic muscle function and possibly injury to other level III structures.

conclusionsFailed hiatal closure is strongly related to pelvic floor disorders. Vaginal birth and levator injury are primary factors affecting this important mechanism.

Indexed as

Pelvic Floor DisordersFemaleHumansImaging, Three-DimensionalParturitionPelvic FloorPostpartum PeriodPregnancyProlapseUltrasonographyLevator hiatusPelvic floor disordersPregnancyUrogenital hiatusVaginal delivery

Identifiers

PMID36129480
PMCPMC10171831

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.