ArticleIntensive care medicine2022
Small wards in the ICU: a favorable measure for controlling the transmission of carbapenem-resistant Klebsiella pneumoniae.
Article in Intensive care medicine, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 22 papers.
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Who cites it
22 citing papers in PubMed.
- A conjugated polymer antimicrobial agent triggers metabolic cascade-mediated killing of carbapenem-resistantFrontiers in cellular and infection microbiology · 2026Article
- Comparative Analysis of Clinical Characteristics and Antimicrobial Resistance of IA-BSI Caused byInternational journal of general medicine · 2026Article
- Characterization of Carbapenem-ResistantInfection and drug resistance · 2026Article
- Review
- Carbapenem-ResistantInfection prevention in practice · 2025Article
- Lessons from Four Years (2021-2024) ofAntibiotics (Basel, Switzerland) · 2025Article
- Assessment of the risk of aerosol transmission of CRKP during bronchoscopy in the intensive care unit.Antimicrobial resistance and infection control · 2025Article
- Targeted next-generation sequencing enhances precision and rapid detection in healthcare-associated infection Surveillance: Unveiling multidrug-resistant colonization in ICUs.New microbes and new infections · 2025Article
- Diverse modes of ceftazidime/avibactam resistance acquisition in carbapenem-resistant Klebsiella pneumoniae and Pseudomonas aeruginosa from a Chinese intensive care unit.Annals of clinical microbiology and antimicrobials · 2025Article
- Impact of healthcare-associated infection on healthcare services and survival of patients with cancer: a propensity score-matched retrospective study.BMC cancer · 2025Article
- A Comprehensive Overview ofInfection and drug resistance · 2025Review
- Clinical and Microbiological Characteristics of Carbapenem-ResistantInfection and drug resistance · 2025Article
- External validation of the ICU-CARB score to predict carbapenem-resistant gram-negative bacteria carriage in critically ill patients upon ICU admission: a multicenter analysis.Antimicrobial resistance and infection control · 2024Article
- Retrospective Case-Control Study of Risk Factors for Carbapenem-ResistantPathogens (Basel, Switzerland) · 2024Article
- Disinfectants efficacy in reducing pathogens related to health-care infection associated in universities hospitals of Gorgan, North of Iran.BMC infectious diseases · 2024Observational
- Genomic study substantiates the intensive care unit as a reservoir for carbapenem-resistantMicrobial genomics · 2024Article
- Development and application of a nomogram model for the prediction of carbapenem-resistantMicrobiology spectrum · 2024Article
- A preliminary exploration on the mechanism of the carbapenem-resistance transformation of Serratia marcescens in vivo.BMC genomics · 2024Article
- Clinical and Molecular Characteristics of Patients with Bloodstream Infections Caused by KPC and NDM Co-Producing Carbapenem-ResistantInfection and drug resistance · 2024Article
- Epidemiology and outcomes of carbapenem-resistantFrontiers in microbiology · 2024Article
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8 authors.
Funding
Abstract
purposeCarbapenem-resistant Klebsiella pneumoniae (CRKP) is one of the leading causes of healthcare-associated infections (HAIs) and is particularly pervasive in intensive care units (ICUs). This study takes ICU layout as the research object, and integrates clinical data and bacterial genome analysis to clarify the role of separate, small wards within the ICU in controlling the transmission of CRKP.
methodsThis study prospectively observed the carriage and spread of CRKP from a long-term in-hospital patient (hereafter called the Patient) colonized with CRKP in the gut and located in a separate, small ward within the ICU. The study also retrospectively investigated CRKP-HAIs in the same ICU. The relationship and transmission between CRKP isolates from the Patient and HAI events in the ICU were explored with comparative genomics.
resultsIn this study, 65 CRKP-HAI cases occurred during the investigation period. Seven CRKP-HAI outbreaks were also observed. A total of 95 nonrepetitive CRKP isolates were collected, including 32 strains from the Patient in the separate small ward. Phylogenetic analysis based on core genome single-nucleotide polymorphism (cgSNP) showed that there were five possible CRKP clonal transmission events and two clonal outbreaks (A1, A2) during the study. CRKP strains from the Patient did not cause CRKP between-patient transmission or outbreaks in the ICU during the 5-year study period.
conclusionThe presence of a long-term hospitalized patient carrying CRKP and positioned in a separate, small ward did not lead to CRKP transmission or infection outbreaks in the ICU. Combining a small-ward ICU layout with normative HAI control measures for multidrug-resistant pathogen infection was effective in reducing CRKP transmission.
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