Evidence map›Paper›PMID 36129301›Full record

ArticleMicrobiology spectrum2022

Microevolution of CG23-I Hypervirulent Klebsiella pneumoniae during Recurrent Infections in a Single Patient.

Yao-Chen Wang, Min-Chi Lu, Yia-Ting Li, Hui-Ling Tang, Pei-Yi Hsiao, Bo-Han Chen, Ru-Hsiou Teng, Chien-Shun Chiou, Yi-Chyi Lai

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Microbiology spectrum, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
0.3field-weighted citation impact, top 55% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed, 4 citations in OpenAlex.

  1. Article
  2. Review
  3. Article
  4. HypervirulentInfection and drug resistance · 2023
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 4 institutions in 1 country.

Yao-Chen Wang *Department of Internal Medicine, Chung Shan Medical Universitygrid.411641.7 Hospital, Taichung, Taiwan.
Min-Chi Lu *Department of Microbiology and Immunology, School of Medicine, China Medical Universitygrid.411508.9grid.254145.3, Taichung, Taiwan.
Yia-Ting Li *Division of Respiratory Therapy, Department of Internal Medicine, Chung Shan Medical Universitygrid.411641.7 Hospital, Taichung, Taiwan.
Hui-Ling TangDepartment of Microbiology and Immunology, School of Medicine, China Medical Universitygrid.411508.9grid.254145.3, Taichung, Taiwan.
Pei-Yi HsiaoDepartment of Microbiology and Immunology, School of Medicine, Chung Shan Medical Universitygrid.411641.7, Taichung, Taiwan.
Bo-Han ChenCentral Region Laboratory, Center for Diagnostics and Vaccine Development, Centers for Disease Control, Ministry of Health and Welfare, Taipei, Taiwan.
Ru-Hsiou TengCentral Region Laboratory, Center for Diagnostics and Vaccine Development, Centers for Disease Control, Ministry of Health and Welfare, Taipei, Taiwan.
Chien-Shun ChiouCentral Region Laboratory, Center for Diagnostics and Vaccine Development, Centers for Disease Control, Ministry of Health and Welfare, Taipei, Taiwan.ORCID 0000-0003-3674-1030
Yi-Chyi LaiDepartment of Internal Medicine, Chung Shan Medical Universitygrid.411641.7 Hospital, Taichung, Taiwan.ORCID 0000-0003-2396-1827
Chung Shan Medical University Hospital · TWMinistry of Health and Welfare · TWChina Medical University · TWChung Shan Medical University · TW

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

CG23-I lineage constitutes the majority of hypervirulent Klebsiella pneumoniae. A diabetic patient suffered six episodes of infections caused by CG23-I K. pneumoniae. A total of nine isolates were collected in 2020. We performed whole-genome sequencing to elucidate the within-patient evolution of CG23-I K. pneumoniae. The maximum pairwise difference among the nine longitudinally collected isolates was five single nucleotide polymorphisms. One of the mutations was at the Asp87 position of GyrA. Four indels were identified, including an initiator tRNAfMet duplication, a tRNAArg deletion, a 7-bp insertion, and a 22-bp deletion. All 9 isolates had the genomic features of CG23-I K. pneumoniae, a chromosome-borne ICE

Indexed as

Klebsiella InfectionsKlebsiella pneumoniaeAnimalsAnti-Bacterial AgentsGenome, BacterialHumansMicePlasmidsReinfectionRNA, Transfer, ArgRNA, Transfer, MetAnti-Bacterial AgentsRNA, Transfer, ArgRNA, Transfer, MetCG23-IgyrA mutationhypervirulentKL1Klebsiella pneumoniaeST23

Identifiers

PMID36129301
PMCPMC9602619
OpenAlexW4296706134

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.