ArticleInfection and immunity2022
A Co-Association of Streptococcus mutans and Veillonella parvula/dispar in Root Caries Patients and
Article in Infection and immunity, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 21 papers, 1 of them a synthesis that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
21 citing papers in PubMed, 1 synthesis or guideline pooled it, 24 citations in OpenAlex.
- Use of the oral microbiota as screening test to identify children at risk for caries development. A systematic review of longitudinal studies.European journal of oral sciences · 2026Pooled it
- Efficacy of toothpaste containing OPTIMEALTH® OR in inhibiting dental plaque and gingivitis: A randomized controlled trial.Medicine · 2025Trial
- Human Oral-AssociatedMicroorganisms · 2026Review
- Microbiome in adult severe caries and cross-kingdom biofilms validation.Clinical oral investigations · 2026Article
- [Isolation, identification, and metabolic characterization of aBeijing da xue xue bao. Yi xue ban = Journal of Peking University. Health sciences · 2026Article
- The role ofFrontiers in oral health · 2026Review
- Filtration-enriched metabolites and their association with salivary microbiota: a combined two-cohort analysis.Journal of oral microbiology · 2026Article
- Co-infection with CbpJournal of oral microbiology · 2026Article
- Folate Production byJournal of microbiology and biotechnology · 2025Article
- Synthesis, Microbiology, and Biophysical Characterization of Mutanofactins from the Human Oral Microbiome.ACS central science · 2025Article
- Effects of a Novel Magnetic Nanomaterial on Oral Biofilms.International dental journal · 2025Article
- The link between inflammatory/ SCFA profiles and oral/gut microbiome: an observational study in patients with ST-segment elevation myocardial infarction.Current research in microbial sciences · 2025Article
- Microbiota-based biomarkers of infection risk in patients undergoing vascular endograft implantation: a pilot study.Frontiers in medicine · 2025Article
- Influence of species composition and cultivation condition on peri-implant biofilm dysbiosisFrontiers in oral health · 2025Article
- The oral microbiome in aging: a window into health and longevity.Journal of oral microbiology · 2025Review
- Veillonella parvula promotes root caries development through interactions with Streptococcus mutans and Candida albicans.Microbial biotechnology · 2024Article
- Emerging liver infection ofAnnals of medicine and surgery (2012) · 2024Article
- Effects of glucose and lactate onMicrobiology spectrum · 2024Article
- High-performing cross-dataset machine learning reveals robust microbiota alteration in secondary apical periodontitis.Frontiers in cellular and infection microbiology · 2024Article
- Efficient Removal of Dental Plaque Biofilm from Training Typodont Teeth via Water Flosser.Bioengineering (Basel, Switzerland) · 2023Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
21 authors at 2 institutions in 1 country.
Funding
Abstract
Root caries in geriatric patients is a growing problem as more people are maintaining their natural teeth into advanced age. We determined the levels of various bacterial species previously implicated in root caries disease or health using quantitative real-time PCR in a pilot study of 7 patients with 1 to 4 root caries lesions per person. Levels of 12 different species on diseased roots compared to healthy (contralateral control) roots were measured. Four species were found at significantly higher levels on diseased roots (Streptococcus mutans, Veillonella parvula/dispar, Actinomyces naeslundii/viscosus, and Capnocytophaga granulosa) compared across all plaque samples. The level of colonization by these species varied dramatically (up to 1,000-fold) between patients, indicating different patients have different bacteria contributing to root caries disease. Neither of the two species previously reported to correlate with healthy roots (C. granulosa and Delftia acidovorans) showed statistically significant protective roles in our population, although D. acidovorans showed a trend toward higher levels on healthy teeth (
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.