ArticleeLife2022
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Article in eLife, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers.
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19citing papers in PubMed
3.8field-weighted citation impact, top 5% of its field
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Who cites it
19 citing papers in PubMed, 27 citations in OpenAlex.
- Dietary vitamin A restricts intestinal tuft cell differentiation.Cell reports · 2026Article
- Influenza-induced tuft cell expansion is associated with changes in ILC2 populations in the distal lungs of mice.Physiological reports · 2026Article
- Influenza-induced tuft cell expansion alters ILC-mediated inflammation.bioRxiv : the preprint server for biology · 2026Article
- Tuft cells shape airway remodeling by eliciting OXGR1- and SOX9-dependent stem cell programs.Nature communications · 2026Article
- Review
- Sympathetic Neurons Promote Small Cell Lung Cancer through the β2-Adrenergic Receptor.Cancer discovery · 2025Article
- Hypoxia-inducible factor 2 regulates alveolar regeneration after repetitive injury in three-dimensional cellular and in vivo models.Science translational medicine · 2025Article
- Article
- Viral infection induces inflammatory signals that coordinate YAP regulation of dysplastic cells in lung alveoli.The Journal of clinical investigation · 2024Article
- G protein subunit GeLife · 2024Article
- Airway Microfold Cells Emerge in the Post-Influenza Lung.American journal of respiratory cell and molecular biology · 2024Article
- Single Cell Analysis of Lung Lymphatic Endothelial Cells and Lymphatic Responses during Influenza Infection.Journal of respiratory biology and translational medicine · 2024Article
- Intestinal Tuft Cells: Morphology, Function, and Implications for Human Health.Annual review of physiology · 2024Review
- Tuft cells are required for a rhinovirus-induced asthma phenotype in immature mice.JCI insight · 2024Article
- Senescence of alveolar epithelial progenitor cells: a critical driver of lung fibrosis.American journal of physiology. Cell physiology · 2023Review
- Article
- An exploratory study for tuft cells in the breast and their relevance in triple-negative breast cancer: the possible relationship of SOX9.BMC cancer · 2023Article
- Pulmonary cancers across different histotypes share hybrid tuft cell/ionocyte-like molecular features and potentially druggable vulnerabilities.Cell death & disease · 2022Article
- Short histological kaleidoscope - recent findings in histology. Part IV.Romanian journal of morphology and embryology = Revue roumaine de morphologie et embryologieReview
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
23 authors at 9 institutions in 2 countries.
Huachao HuangColumbia Center for Human Development, Department of Medicine, Columbia University Medical Center, New York, United States.
Yinshan FangColumbia Center for Human Development, Department of Medicine, Columbia University Medical Center, New York, United States.ORCID 0000-0001-9249-4498
Ming JiangInstitute of Genetics, the Children's Hospital, Zhejiang University School of Medicine, Hangzhou, China.
Yihan ZhangMucosal Immunology and Biology Research Center, Massachusetts General Hospital, Harvard Medical School, Boston, United States.
Jana BiermannDivision of Hematology/Oncology, Department of Medicine, Columbia University Irving Medical Center, New York, United States.ORCID 0000-0002-8907-4633
Johannes C MelmsDivision of Hematology/Oncology, Department of Medicine, Columbia University Irving Medical Center, New York, United States.ORCID 0000-0002-5410-6586
Jennifer A DanielssonDepartment of Anesthesiology, Columbia University Irving Medical Center, New York, United States.
Ying YangProgram in Epithelial Biology, Stanford University School of Medicine, Stanford, United States.ORCID 0000-0002-4197-6216
Li QiangDepartment of Pathology & Cell Biology, Columbia University Medical Center, New York, United States.ORCID 0000-0001-8322-1797
Jia LiuState Key Laboratory of Virology, Wuhan Institute of Virology, Center for Biosafety Mega-Science, Chinese Academy of Sciences, Wuhan, China.
Yiwu ZhouDepartment of Forensic Medicine, Tongji Medical College of Huazhong University of Science and Technology, Wuhan, China.
Manli WangState Key Laboratory of Virology, Wuhan Institute of Virology, Center for Biosafety Mega-Science, Chinese Academy of Sciences, Wuhan, China.
Zhihong HuState Key Laboratory of Virology, Wuhan Institute of Virology, Center for Biosafety Mega-Science, Chinese Academy of Sciences, Wuhan, China.ORCID 0000-0002-1560-0928
Timothy C WangDivision of Digestive and Liver Diseases, Department of Medicine, Columbia University Medical Center, New York, United States.
Anjali SaqiDepartment of Pathology & Cell Biology, Columbia University Medical Center, New York, United States.
Jie SunCarter Immunology Center, the University of Virginia, Charlottesville, United States.
Ichiro MatsumotoMonell Chemical Senses Center, Philadelphia, United States.
Wellington V CardosoColumbia Center for Human Development, Department of Medicine, Columbia University Medical Center, New York, United States.ORCID 0000-0002-8868-9716
Charles W EmalaDepartment of Anesthesiology, Columbia University Irving Medical Center, New York, United States.
Jian ZhuDepartment of Pathology, Ohio State University College of Medicine, Columbus, United States.
Benjamin IzarDivision of Hematology/Oncology, Department of Medicine, Columbia University Irving Medical Center, New York, United States.ORCID 0000-0003-2379-6702
Hongmei MouMucosal Immunology and Biology Research Center, Massachusetts General Hospital, Harvard Medical School, Boston, United States.
Jianwen QueColumbia Center for Human Development, Department of Medicine, Columbia University Medical Center, New York, United States.ORCID 0000-0002-6540-6701
Columbia University Irving Medical Center · USChinese Academy of Sciences · CNHarvard University · USCarter Center · USChildren's Hospital of Zhejiang University · CNHuazhong University of Science and Technology · CNMonell Chemical Senses Center · USStanford University · USThe Ohio State University · US
Funding
Tumor Biology and Microenvironment ProgramP30CA013696 · NCI · COLUMBIA UNIV NEW YORK MORNINGSIDE · PI Anil K Rustgi · 1985 to 2026
$115.3MThe Role of Stem Cells and the Microenvironment in Gastrointestinal CancersR35CA210088 · NCI · COLUMBIA UNIVERSITY HEALTH SCIENCES · PI Timothy Cragin Wang · 2017 to 2026
$10.2MThe Organoid and Cell Culture CoreP30DK132710 · NIDDK · COLUMBIA UNIVERSITY HEALTH SCIENCES · PI Robert F. Schwabe · 2022 to 2026
$7.2MBasal Progenitor Cells and Eosinophilic EsophagitisR01DK100342 · NIDDK · UNIVERSITY OF ROCHESTER · PI QUE, JIANWEN · 2014 to 2022
$3.3MImprove Lung Regeneration Through Targeting Tuft Cells Following Viral InfectionR01HL159675 · NHLBI · COLUMBIA UNIVERSITY HEALTH SCIENCES · PI QUE, JIANWEN · 2021 to 2024
$2.4MVEGF/KDR Signaling in Airway Epithelial Regeneration and DiseaseR01HL152293 · NHLBI · COLUMBIA UNIVERSITY HEALTH SCIENCES · PI QUE, JIANWEN · 2021 to 2024
$2.0MSignaling Mechanisms Promoting Barrett’s MetaplasiaR01DK120650 · NIDDK · COLUMBIA UNIVERSITY HEALTH SCIENCES · PI QUE, JIANWEN · 2019 to 2022
$1.8MIMPACT OF PRENATAL VITAMIN A DEFICIENCY ON CELL FATE ALTERATIONS IN ADULT AIRWAY HYPERRESPONSIVENESSR01HL145302 · NHLBI · TEXAS A&M AGRILIFE RESEARCH · PI SUZUKI, MASAKO · 2020 to 2023
$1.6MAntagonism of the Calcium -Activated Chloride Channel TMEM16A; Beneficial Therapeutic Effects on Airway Epithelium and Smooth MuscleK08HL132203 · NHLBI · COLUMBIA UNIVERSITY HEALTH SCIENCES · PI DANIELSSON, JENNIFER ANN · 2017 to 2021
$821kLeica Stellaris 8 Confocal MicroscopeS10OD032447 · OD · COLUMBIA UNIVERSITY HEALTH SCIENCES · PI SNOECK, HANS-WILLEM E · 2022 to 2022
$652kBD Biosciences InfluxS10OD020056 · OD · COLUMBIA UNIVERSITY HEALTH SCIENCES · PI SNOECK, HANS-WILLEM E · 2015 to 2015
$600kTuft Cells Modulate Macrophage Response Following Lung Viral InfectionR21AI163753 · NIAID · COLUMBIA UNIVERSITY HEALTH SCIENCES · PI QUE, JIANWEN · 2022 to 2023
$446kNCI NIH HHS P30 CA013696NCI NIH HHS R35 CA210088NHLBI NIH HHS K08 HL132203NHLBI NIH HHS R01 HL145302NHLBI NIH HHS R01 HL152293NHLBI NIH HHS R01 HL159675NIAID NIH HHS R21 AI163753NIDDK NIH HHS P30 DK132710NIDDK NIH HHS R01 DK100342NIDDK NIH HHS R01 DK120650NIH HHS S10 OD020056NIH HHS S10 OD032447
Abstract
Viral infection often causes severe damage to the lungs, leading to the appearance of ectopic basal cells (EBCs) and tuft cells in the lung parenchyma. Thus far, the roles of these ectopic epithelial cells in alveolar regeneration remain controversial. Here, we confirm that the ectopic tuft cells are originated from EBCs in mouse models and COVID-19 lungs. The differentiation of tuft cells from EBCs is promoted by Wnt inhibition while suppressed by Notch inhibition. Although progenitor functions have been suggested in other organs, pulmonary tuft cells don't proliferate or give rise to other cell lineages. Consistent with previous reports,
Indexed as
COVID-19AnimalsBiomarkersCell DifferentiationCell LineageEpithelial CellsMiceTamoxifenTrans-ActivatorsBiomarkersTamoxifenTrans-ActivatorsTrp63 protein, mousealveolar regenerationbasal cellscell biologyCOVID-19lung regenerationmouseregenerative medicinestem cellstuft cellsviral infection
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.