ArticleJournal of the American Heart Association2022
Insulin Resistance Is Associated With Heart Failure With Recovered Ejection Fraction in Patients Without Diabetes.
Article in Journal of the American Heart Association, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers, 1 of them a synthesis that pooled it.
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Who cites it
18 citing papers in PubMed, 1 synthesis or guideline pooled it, 38 citations in OpenAlex.
- The WATCH-DM risk score estimates clinical outcomes in type 2 diabetic patients with heart failure with preserved ejection fraction.Scientific reports · 2024Pooled it
- Metabolic and vascular insulin resistance: partners in the pathogenesis of cardiovascular disease in diabetes.American journal of physiology. Heart and circulatory physiology · 2025Review
- Evaluating the impact of metabolic indicators and scores on cardiovascular events using machine learning.Diabetology & metabolic syndrome · 2025Article
- Subclinical hypothyroidism: a new predictor of heart failure with improved ejection fraction in HFrEF patients.Internal and emergency medicine · 2025Article
- Course and trajectories of insulin resistance, incident heart failure and all-cause mortality in nondiabetic people.Endocrine · 2025Article
- Association between sleep apnea-specific novel hypoxic metrics and disturbances in glucose and lipid metabolism.Frontiers in endocrinology · 2025Article
- Impact of DPP-4 Inhibitors in Patients with Diabetes Mellitus and Heart Failure: An In-Depth Review.Medicina (Kaunas, Lithuania) · 2024Review
- Triglyceride glucose index is a risk factor for heart failure: A prospective cohort study.ESC heart failure · 2024Article
- Evidence of a bi-directional relationship between heart failure and diabetes: a strategy for the detection of glucose abnormalities and diabetes prevention in patients with heart failure.Cardiovascular diabetology · 2024Review
- Advances in the Insulin-Heart Axis: Current Therapies and Future Directions.International journal of molecular sciences · 2024Review
- Epicardial adipose tissue volume and density are associated with heart failure with improved ejection fraction.Cardiovascular diabetology · 2024Article
- Independent relationship between sleep apnea-specific hypoxic burden and glucolipid metabolism disorder: a cross-sectional study.Respiratory research · 2024Article
- Clinical Perspective of Myocardial Recovery and Improvement: Definitions, Prevalence, and Relevance.Methodist DeBakey cardiovascular journal · 2024Review
- The Negative Impact of Insulin Resistance/Hyperinsulinemia on Chronic Heart Failure and the Potential Benefits of Its Screening and Treatment.Biomedicines · 2023Article
- A low-carbohydrate diet in place of SGLT2i therapy in a patient with diabetic cardiomyopathy.Endocrinology, diabetes & metabolism case reports · 2023Article
- High triglyceride-glucose (TyG) index is associated with poor prognosis of heart failure with preserved ejection fraction.Cardiovascular diabetology · 2023Article
- Long-term glycemic variability predicts compromised development of heart failure with improved ejection fraction: a cohort study.Frontiers in endocrinology · 2023Article
- Glucose-Induced Hemodynamic and Metabolic Response of Skeletal Muscle in Heart Failure Patients with Reduced vs. Preserved Ejection Fraction-A Pilot Study.Journal of cardiovascular development and disease · 2022Article
Corrections and comments
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Authors and funding
12 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Background Because of advances in medical treatments, a substantial proportion of patients with heart failure (HF) have experienced recovery of ejection fraction (EF), termed HF with recovered EF (HFrecEF). Insulin resistance (IR) is prevalent in HF and tightly related with prognosis. This study investigates the relationship between IR and the incidence of HFrecEF in patients who are nondiabetic. Methods and Results A total of 262 patients with HF with reduced EF (HFrEF) who were nondiabetic were consecutively enrolled. Patients were classified into HFrecEF (follow-up EF>40% and ≥10% absolute increase) or otherwise persistent HFrEF based on repeat echocardiograms after 12 months. IR was estimated by an updated homeostasis model assessment for IR (HOMA2-IR). The median HOMA2-IR level was 1.05 (interquartile range [IQR], 0.67-1.63) in our cohort of patients with HF who were nondiabetic. During follow-up, 121 (odds ratio [OR], 46.2% [95% CI 40.2-52.2]) patients developed HFrecEF. Compared with patients with HFrEF, patients with HFrecEF had significantly lower HOMA2-IR levels (0.92 [IQR, 0.61-1.37] versus 1.14 [IQR, 0.75-1.78],
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