Evidence map›Paper›PMID 36128887›Full record

ArticleMagnetic resonance in medicine2023

Real-time trajectory guide tracking for intraoperative MRI-guided neurosurgery.

Miles E Olsen, Ethan K Brodsky, Jonathan A Oler, Marissa K Riedel, Sascha A L Mueller, Scott C Vermilyea, Jeanette M Metzger, Yunlong Tao, Kevin G Brunner, Azam S Ahmed and 4 more

Open access · hybridAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Magnetic resonance in medicine, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
0.8field-weighted citation impact, top 27% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed, 6 citations in OpenAlex.

  1. Review
  2. Article
  3. Article
  4. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

14 authors at 2 institutions in 1 country.

Miles E OlsenDepartment of Medical Physics, University of Wisconsin-Madison, Madison, Wisconsin, USA.ORCID 0000-0002-3569-1732
Ethan K BrodskyDepartment of Medical Physics, University of Wisconsin-Madison, Madison, Wisconsin, USA.
Jonathan A OlerDepartment of Psychiatry, University of Wisconsin-Madison, Madison, Wisconsin, USA.ORCID 0000-0002-1333-6924
Marissa K RiedelDepartment of Psychiatry, University of Wisconsin-Madison, Madison, Wisconsin, USA.
Sascha A L MuellerDepartment of Psychiatry, University of Wisconsin-Madison, Madison, Wisconsin, USA.
Scott C VermilyeaWisconsin National Primate Research Center, University of Wisconsin-Madison, Madison, Wisconsin, USA.
Jeanette M MetzgerWisconsin National Primate Research Center, University of Wisconsin-Madison, Madison, Wisconsin, USA.
Yunlong TaoWaisman Center, University of Wisconsin-Madison, Madison, Wisconsin, USA.
Kevin G BrunnerWisconsin National Primate Research Center, University of Wisconsin-Madison, Madison, Wisconsin, USA.
Azam S AhmedDepartment of Neurological Surgery, University of Wisconsin-Madison, Madison, Wisconsin, USA.
Su-Chun ZhangWaisman Center, University of Wisconsin-Madison, Madison, Wisconsin, USA.
Marina E EmborgDepartment of Medical Physics, University of Wisconsin-Madison, Madison, Wisconsin, USA.
Ned H KalinDepartment of Psychiatry, University of Wisconsin-Madison, Madison, Wisconsin, USA.
Walter F BlockDepartment of Medical Physics, University of Wisconsin-Madison, Madison, Wisconsin, USA.ORCID 0000-0002-2262-9972
University of Wisconsin–Madison · USUniversity of Wisconsin System · US

Funding

WNPRC Supplemental Request for Nonhuman Primate Enclosures to Equip HIV/AIDS-Related Research FacilitiesP51OD011106 · OD · UNIVERSITY OF WISCONSIN-MADISON · PI Dorota A. Grejner-Brzezinska · 2012 to 2026
$150.7M
DEVELOPMENT AND REGULATION OF EMOTION IN PRIMATESR01MH046729 · NIMH · UNIVERSITY OF WISCONSIN-MADISON · PI Ned H Kalin · 1990 to 2026
$15.3M
Brain Mechanisms Mediating Genetic Risk For Anxiety And DepressionR01MH081884 · NIMH · UNIVERSITY OF WISCONSIN-MADISON · PI Ned H Kalin · 2008 to 2026
$14.8M
Waisman Intellectual and Developmental Disabilities Research Center Down Syndrome RegistryU54HD090256 · NICHD · UNIVERSITY OF WISCONSIN-MADISON · PI POLLAK, SETH D · 2016 to 2020
$6.0M
Individualized Cell Therapy for Parkinson's DiseaseR01NS076352 · NINDS · UNIVERSITY OF WISCONSIN-MADISON · PI ZHANG, SU-CHUN · 2012 to 2016
$3.1M
Reconstruction and Regulation of Neural Circuitry by Human NeuronsR01NS096282 · NINDS · UNIVERSITY OF WISCONSIN-MADISON · PI ZHANG, SU-CHUN · 2017 to 2021
$1.7M
Clinical Neuroengineering Training ProgramT32EB011434 · NIBIB · UNIVERSITY OF WISCONSIN-MADISON · PI MEYERAND, MARY E., PEARCE, ROBERT A · 2011 to 2015
$869k
NIBIB NIH HHS T32 EB011434NICHD NIH HHS U54 HD090256NIH HHS P51 OD011106NIH HHS P51OD011106NIH HHS R01-MH046729NIH HHS R01NS076352NIMH NIH HHS R01 MH046729NIMH NIH HHS R01 MH081884NINDS NIH HHS R01 NS076352NINDS NIH HHS R01 NS096282
6 · The paper itself

Abstract

purposeIn current intraoperative MRI (IMRI) methods, an iterative approach is used to aim trajectory guides at intracerebral targets: image MR-visible features, determine current aim by fitting model to image, manipulate device, repeat. Infrequent updates are produced by such methods, compared to rapid optically tracked stereotaxy used in the operating room. Our goal was to develop a real-time interactive IMRI method for aiming.

methodsThe current trajectory was computed from two points along the guide's central axis, rather than by imaging the entire device. These points were determined by correlating one-dimensional spokes from a radial sequence with the known cross-sectional projection of the guide. The real-time platform RTHawk was utilized to control MR sequences and data acquisition. On-screen updates were viewed by the operator while simultaneously manipulating the guide to align it with the planned trajectory. Accuracy was quantitated in a phantom, and in vivo validation was demonstrated in nonhuman primates undergoing preclinical gene (

resultsUpdates were produced at 5 Hz In 10 phantom experiments at a depth of 48 mm, the cannula tip was placed with radial error of (min, mean, max) = (0.16, 0.29, 0.68) mm. Successful in vivo delivery of payloads to all 14 targets was demonstrated across nine surgeries with depths of (min, mean, max) = (33.3, 37.9, 42.5) mm.

conclusionA real-time interactive update rate was achieved, reducing operator fatigue without compromising accuracy. Qualitative interpretation of images during aiming was rendered unnecessary by objectively computing device alignment.

Indexed as

NeurosurgeryAnimalsCross-Sectional StudiesImaging, Three-DimensionalMagnetic Resonance ImagingPhantoms, Imagingcell deliverygene deliveryintraoperative MRIneurosurgerynonhuman primatesreal-time

Identifiers

PMID36128887
PMCPMC9930741
OpenAlexW4296962291

What OpenQuestion holds

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LicenceCC BY-NC
Read underepoch 390

Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.