ArticleJournal of thrombosis and haemostasis : JTH2022
Predicting bleeding after liver biopsy using comprehensive clinical and laboratory investigations: A prospective analysis of 302 procedures.
Article in Journal of thrombosis and haemostasis : JTH, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT06231082 (Bloody or Well Done. How Would You Like Your Liver Biopsy, Sir? Post Liver bIopsy abdoMinal PaIn as Predictive Factor for Liver bleeDing), which is not on this map. Cited by 13 papers.
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The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Bloody or Well Done. How Would You Like Your Liver Biopsy, Sir? Post Liver bIopsy abdoMinal PaIn as Predictive Factor for Liver bleeDing (LIMPID)
Who cites it
13 citing papers in PubMed, 26 citations in OpenAlex.
- Histotripsy for liver tumours: a systematic review and meta-analysis of current clinical evidence.EClinicalMedicine · 2026Article
- Impact of MRI Texture Analysis on Complication Rate in MRI-Guided Liver Biopsies.Journal of imaging informatics in medicine · 2025Article
- Utility of tumor and non-tumor biopsies during percutaneous radiofrequency ablation for hepatocellular carcinoma.JHEP reports : innovation in hepatology · 2025Article
- Diagnostic yield and adverse events of liver biopsy in intensive-care-unit patients: a multicenter retrospective observational cohort study.Annals of intensive care · 2025Article
- Prediction and prevention of post-procedural bleedings in patients with cirrhosis.Clinical and molecular hepatology · 2025Review
- Unravelling risk factors for delayed bleeding following ultrasonography-guided liver biopsy: a retrospective analysis.Translational gastroenterology and hepatology · 2025Article
- [Analysis of risk factors for bleeding as a complication of ultrasound-guided percutaneous liver biopsy examination].Zhonghua gan zang bing za zhi = Zhonghua ganzangbing zazhi = Chinese journal of hepatology · 2024Article
- What is the Safe Observation Period for Image-Guided Percutaneous Liver Biopsies?Cardiovascular and interventional radiology · 2024Article
- Expert opinion on bleeding risk from invasive procedures in cirrhosis.JHEP reports : innovation in hepatology · 2024Article
- Treating periprocedural bleeding in patients with cirrhosis.Journal of thrombosis and thrombolysis · 2024Review
- How to manage hemostasis in patients with liver disease during interventions.Hematology. American Society of Hematology. Education Program · 2023Review
- Transjugular liver biopsy: enlarge the indications for liver biopsy with reliable diagnostic quality.BMC gastroenterology · 2023Article
- Predicting bleeding after liver biopsy using comprehensive clinical and laboratory investigations: A prospective analysis of 302 procedures.Journal of thrombosis and haemostasis : JTH · 2022Article
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Authors and funding
12 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundLiver biopsy carries a small risk of bleeding complications. No validated clinical or laboratory tool helps predict liver biopsy-related bleeding.
objectivesTo determine whether global hemostasis tests and/or a clinical questionnaire could identify patients at risk of liver biopsy-related bleeding. PATIENTS/
methodsConsecutive patients scheduled for liver biopsy with an overnight hospital stay were prospectively included. Before liver biopsy, routine hemostasis tests, Platelet Function Analyzer 100, thromboelastometry, thrombin generation assay, plasma clot lysis time, and a clinical questionnaire were performed. Bleeding was defined as a liver hematoma or new free fluid on a systematic ultrasound performed 24 h after liver biopsy or a decrease in hemoglobin level of 2 g/dL or more in patients with pre-existing free fluid in the abdominal cavity.
resultsThree hundred two patients were included: 173 underwent percutaneous and 129 transjugular liver biopsy. There were 21 bleeding episodes (7%); 20 based on ultrasonographic criteria, 1 on laboratory criteria. None of the hemostasis tests and no item of the clinical questionnaire were associated with liver biopsy-related bleeding in the overall study group. Same results were obtained in subgroup analyses focusing on patients who underwent percutaneous liver biopsy, transjugular liver biopsy, or on patients with cirrhosis. Pain 2 h after liver biopsy was more frequent in patients with liver biopsy-related bleeding (55% vs. 23% p = .002).
conclusionsAn extensive hemostasis workup, including global hemostasis assays, does not improve prediction of liver biopsy-related bleeding. Pain 2 h after liver biopsy should alert the clinician to the possibility of procedure-related bleeding.
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