Evidence map›Paper›PMID 36128657›Full record

ArticleESC heart failure2022

Contemporary outcome of subsequent pregnancies in patients with previous peripartum cardiomyopathy.

Sorel Goland, Jacob George, Uri Elkayam, Sara Shimoni, Irena Fugenfirov, Edi Vaisbuch, Michael Arad, Dov Freimark, Michal Simchen, Rafael Kuperstein

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in ESC heart failure, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers, 2 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
8citing papers in PubMed, 2 pooled it
2.6field-weighted citation impact, top 9% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

8 citing papers in PubMed, 2 syntheses or guidelines pooled it, 17 citations in OpenAlex.

  1. Pooled it
  2. Pooled it
  3. Review
  4. Subsequent pregnancies in peripartum cardiomyopathy: Patient-level differences and decision-making.American heart journal plus : cardiology research and practice · 2024
    Article
  5. What Do We Know about Peripartum Cardiomyopathy? Yesterday, Today, Tomorrow.International journal of molecular sciences · 2024
    Review
  6. Diagnosis and management of peripartum cardiomyopathy and recurrence risk.International journal of cardiology. Congenital heart disease · 2024
    Article
  7. Five cases of Peripartum Cardiomyopathy in Malawi.Malawi medical journal : the journal of Medical Association of Malawi · 2023
    Article
  8. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors at 5 institutions in 2 countries.

Sorel GolandThe Heart Institute, Kaplan Medical Center, Rehovot, Israel.
Jacob GeorgeThe Heart Institute, Kaplan Medical Center, Rehovot, Israel.
Uri ElkayamDepartment of Medicine, Division of Cardiovascular Medicine and Department of Obstetrics and Gynecology, Keck School of Medicine, University of Southern California, Los Angeles, CA, USA.
Sara ShimoniThe Heart Institute, Kaplan Medical Center, Rehovot, Israel.
Irena FugenfirovThe Heart Institute, Kaplan Medical Center, Rehovot, Israel.
Edi VaisbuchHadassah Medical School, Hebrew University, Jerusalem, Israel.
Michael AradLeviev Heart Center Sheba Medical Center, Ramat Gan, Israel.
Dov FreimarkLeviev Heart Center Sheba Medical Center, Ramat Gan, Israel.
Michal SimchenSackler School of Medicine, Tel Aviv University, Tel Aviv, Israel.
Rafael KupersteinLeviev Heart Center Sheba Medical Center, Ramat Gan, Israel.
Hebrew University of Jerusalem · ILKaplan Medical Center · ILSheba Medical Center · ILTel Aviv University · ILUniversity of Southern California · US

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

aimsTo describe the effect of subsequent pregnancies (SSP) on left ventricular (LV) function and outcomes in patients with peripartum cardiomyopathy (PPCM).

methodsAmong146 women with PPCM who were prospectively followed at two medical centres in Israel (2007-2019), 75 SSPs (in 50 women) were identified: 8 miscarriages, 8 terminations, and 59 life birth.

resultsForty-five patients with 59 full-term SSPs [mean age was 32.9 ± 4.1 years, LV ejection fraction (LVEF) 57.7 ± 5.1%] were analysed. Data on LVEF at 1-month post-delivery were available in 46 and at 6 months in 36 SSPs. There was a small decrease in the mean LVEF, mostly at third trimester (57.2 ± 5.6 vs. 54.4. ± 7.3, P < 0.001); and at 1-mont (57.9 ± 5.7% vs. 55.4 ± 6.1%, P = 0.001) and at 6-month post-delivery (57.4 ± 6.1 vs. 55.3 ± 7.9%, P = 0.03). In patients with pre-SSP LV LVEF ≥55%, a mild reduction in the mean group LVEF was seen at 1-month post-delivery (P = 0.009). One patient with pre-SSP LVEF ≥55% developed severe relapse. In patients with pre-SSP LVEF <55%, a mild reduction in LVEF was obtained mostly at third trimester (51.1 ± 5.6 vs 47.0 ± 7.4%, P < 0.001), which persisted at 6 months (P = 0.03). A relapse was observed in three (25%) women with LVEF <55%. There was no maternal mortality, 32 patients delivered by caesarean section, and there were no foetal complications.

conclusionsOur study indicates a favourable outcome and low likelihood of maternal mortality associated with SSP in women with a history of PPCM and recovered LV systolic function. SSP was associated with a slight reduction in LVEF mostly during the third trimester, which persisted up to 6 months after delivery.

Indexed as

CardiomyopathiesPregnancy Complications, CardiovascularAdultCesarean SectionFemaleHumansMalePeripartum PeriodPregnancyRecurrenceCardiomyopathyOutcomePeripartumPregnanciesSubsequent

Identifiers

PMID36128657
PMCPMC9773727
OpenAlexW4297875027

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.