ArticleChemical science2022
TADF-based NIR-II semiconducting polymer dots for
Article in Chemical science, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers.
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Who cites it
8 citing papers in PubMed.
- Supramolecular host-guest modulated thermally activated delayed fluorescence for photodynamic therapy.Chemical science · 2026Article
- Enhancing biological imaging with high-performance probes based on thermally activated delayed fluorescence.iScience · 2025Review
- Energy Gap Law-Harnessing Design of Highly Second Near-Infrared Emissive 34π-Annulated Porphyrinoids for In Vivo Imaging.Journal of the American Chemical Society · 2025Article
- Development of TheranosticACS applied bio materials · 2025Article
- Molecular Gold Nanoclusters for Advanced NIR-II Bioimaging and Therapy.Chemical reviews · 2025Review
- The Golden Age of Thermally Activated Delayed Fluorescence Materials: Design and Exploitation.Chemical reviews · 2024Review
- Semiconducting polymer dots for multifunctional integrated nanomedicine carriers.Materials today. Bio · 2024Review
- Quasi-dendritic sulfonate-based organic small molecule for high-quality NIR-II bone-targeted imaging.Journal of nanobiotechnology · 2023Article
Corrections and comments
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Authors and funding
10 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Intraoperative fluorescence imaging in the second near-infrared (NIR-II) region heralds a new era in image-guided surgery since the success in the first-in-human liver-tumor surgery guided by NIR-II fluorescence. Limited by the conventional small organic NIR dyes such as FDA-approved indocyanine green with suboptimal NIR-II fluorescence and non-targeting ability, the resulting shallow penetration depth and high false positive diagnostic values have been challenging. Described here is the design of NIR-II emissive semiconducting polymer dots (Pdots) incorporated with thermally activated delayed fluorescence (TADF) moieties to exhibit emission maxima of 1064-1100 nm and fluorescence quantum yields of 0.40-1.58% in aqueous solutions. To further understand how the TADF units affect the molecular packing and the resulting optical properties of Pdots, in-depth and thorough density-functional theory calculations were carried out to better understand the underlying mechanisms. We then applied these Pdots for
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.