Evidence map›Paper›PMID 36127808›Full record

ArticleCancer medicine2023

Genetic ancestry, differential gene expression, and survival in pediatric B-cell acute lymphoblastic leukemia.

Freddy A Barragan, Lauren J Mills, Andrew R Raduski, Erin L Marcotte, Kelsey E Grinde, Logan G Spector, Lindsay A Williams

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Cancer medicine, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
0.6field-weighted citation impact, top 31% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed, 3 citations in OpenAlex.

  1. Article
  2. Incidence and Mortality Rates for Childhood Acute Lymphoblastic Leukemia in Puerto Rican Hispanics, 2012-2016.Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology · 2023
    Article
  3. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 2 institutions in 1 country.

Freddy A BarraganDepartment of Mathematics, Statistics, and Computer Science, Macalester College, St. Paul, Minnesota, USA.ORCID 0000-0001-7317-0412
Lauren J MillsDivision of Epidemiology and Clinical Research, Department of Pediatrics, University of Minnesota, Minneapolis, Minnesota, USA.ORCID 0000-0002-8914-2587
Andrew R RaduskiDivision of Epidemiology and Clinical Research, Department of Pediatrics, University of Minnesota, Minneapolis, Minnesota, USA.ORCID 0000-0002-7069-6934
Erin L MarcotteDivision of Epidemiology and Clinical Research, Department of Pediatrics, University of Minnesota, Minneapolis, Minnesota, USA.ORCID 0000-0002-9630-9701
Kelsey E GrindeDepartment of Mathematics, Statistics, and Computer Science, Macalester College, St. Paul, Minnesota, USA.ORCID 0000-0001-8306-9238
Logan G SpectorDivision of Epidemiology and Clinical Research, Department of Pediatrics, University of Minnesota, Minneapolis, Minnesota, USA.ORCID 0000-0003-2516-0222
Lindsay A WilliamsDivision of Epidemiology and Clinical Research, Department of Pediatrics, University of Minnesota, Minneapolis, Minnesota, USA.ORCID 0000-0003-3842-4629
University of Minnesota · USMacalester College · US

Funding

Sex and racial/ethnic differences in B-ALL genomicsR01CA239701 · NCI · UNIVERSITY OF MINNESOTA · PI SCHEURER, MICHAEL E., SPECTOR, LOGAN G. · 2020 to 2024
$3.5M
NCI NIH HHS 1R01CA239701-01A1S1NCI NIH HHS R01 CA239701
6 · The paper itself

Abstract

backgroundBlack children have lower incidence yet worse survival than White and Latinx children with B-cell acute lymphoblastic leukemia (B-ALL). It is unclear how reported race/ethnicity (RRE) is associated with death in B-ALL after accounting for differentially expressed genes associated with genetic ancestry.

methodsUsing Phase 1 and 2 NCI TARGET B-ALL cases (N = 273; RRE-Black = 21, RRE-White = 162, RRE-Latinx = 69, RRE-Other = 9, RRE-Unknown = 12), we estimated proportions of African (AFR), European (EUR), and Amerindian (AMR) genetic ancestry. We estimated hazard ratios (HR) and 95% confidence intervals (95% CI) between ancestry and death while adjusting for RRE and clinical measures. We identified genes associated with genetic ancestry and adjusted for them in RRE and death associations.

resultsGenetic ancestry varied within RRE (RRE-Black, AFR proportion: Mean: 78.5%, Range: 38.2%-93.6%; RRE-White, EUR proportion: Mean: 94%, Range: 1.6%-99.9%; RRE-Latinx, AMR proportion: Mean: 52.0%, Range: 1.2%-98.7%). We identified 10, 1, and 6 differentially expressed genes (p

conclusionsOur work highlights B-ALL survival differences by RRE after adjusting for ancestry differentially expressed genes suggesting other factors impacting survival are important.

Indexed as

Burkitt LymphomaPrecursor B-Cell Lymphoblastic Leukemia-LymphomaChildEthnicityGene ExpressionHumansProportional Hazards Modelsacute lymphoblastic leukemiagenetic ancestrysurvival disparities

Identifiers

PMID36127808
PMCPMC9972134
OpenAlexW4296959139

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.