ArticleThe Korean journal of internal medicine2022
Neuromuscular blocking agents and opioids are major risk factors for developing pressure injuries in patients in the intensive care unit.
Article in The Korean journal of internal medicine, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.
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Who cites it
4 citing papers in PubMed, 5 citations in OpenAlex.
- Neuromuscular blockade and their monitoring in the intensive care unit: a multicenter observational prospective study.Annals of intensive care · 2025Article
- Physical and Cognitive Impairments at ICU Discharge are Associated with High Long-Term Mortality in ICU Survivors with Solid Malignancies: A Retrospective Cohort Study.Therapeutics and clinical risk management · 2025Article
- Preventing pressure injuries in individuals with impaired mobility: Best practices and future directions.Journal of surgery and research · 2025Article
- Comparing the Waterlow and Jackson/Cubbin pressure injury risk scales in intensive care units: A multi-centre study.International wound journal · 2024Article
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Authors and funding
5 authors at 1 institution in 1 country.
Funding
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Abstract
BACKGROUND/
aimsPatients in the intensive care unit (ICU) are at high risk for developing pressure injuries, which can cause severe complications and even increase the mortality risk. Therefore, prevention of pressure injuries is most important. In this study, we investigated the risk factors of pressure injury development in patients admitted to the ICU.
methodsWe retrospectively analyzed patients ages > 18 years admitted to the medical ICU in a tertiary hospital between January and December 2019. We collected patient baseline characteristics, medications received, mechanical ventilation or hemodialysis use, laboratory findings, and date of pressure injury onset and characteristics.
resultsWe analyzed 666 patients who did not have pressure injuries at ICU admission. Pressure injuries developed in 102 patients (15%). The risk of pressure injury development increased as the administration days for neuromuscular blocking agents (NMBAs; odds ratio [OR], 1.138; p = 0.019) and opioids (OR, 1.084; p = 0.028) increased, and if the patient had problem with friction and shear (OR, 2.203; p = 0.011).
conclusionThe prolonged use of NMBAs and opioids can increase the risk of pressure injury development. Because these medications are associated with immobilization, using both should be minimized and patient early mobilization should be promoted. Among the Braden subscales, "friction and shear" was associated with the development of pressure injuries in ICU patients.
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