ArticleBMC medicine2022
L-shaped association of serum 25-hydroxyvitamin D concentrations with cardiovascular and all-cause mortality in individuals with osteoarthritis: results from the NHANES database prospective cohort study.
Article in BMC medicine, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 75 papers.
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Who cites it
75 citing papers in PubMed, 96 citations in OpenAlex.
- Biological Aging Mediates the Associations Between Multiple Serum Micronutrients and All-Cause Mortality Among U.S. Adults.Biological trace element research · 2026Article
- Unveiling the BMI Risk Threshold for Osteoarthritis: Multi-Database Causal and Nonlinear Evidence.Diabetes, obesity & metabolism · 2026Article
- Association of serum 25-hydroxyvitamin D concentrations with premature mortality in adult U.S. patients with sarcopenia.BMC public health · 2026Article
- Article
- Geriatric Nutritional Risk Index and risks of all-cause, cardiovascular, and diabetes-related mortality in adults with obesity: A nationally representative cohort study.American heart journal plus : cardiology research and practice · 2026Article
- Body roundness index mediates the association between high-density lipoprotein cholesterol and diabetic retinopathy: a population-based cross-sectional study.BMC endocrine disorders · 2026Article
- Nonlinear association of triglyceride-glucose body mass index with all-cause mortality in postmenopausal women, a retrospective cohort study: Evidence from the 2001 to 2014 National Health and nutrition examination survey.International journal of gynaecology and obstetrics: the official organ of the International Federation of Gynaecology and Obstetrics · 2026Article
- Association between sarcopenia and mortality in patients with osteoarthritis.Clinical rheumatology · 2026Article
- Allostatic Load of Glucose Homeostasis, Epigenetic Biomarkers, and All-Cause and Cardiovascular Death: A Prospective Cohort Study.Journal of the American Heart Association · 2026Article
- Association of Vitamin D Levels and Mortality in Overactive Bladder: Nonlinear Dose-Response and Threshold Effect.Food science & nutrition · 2026Article
- Association of 25-hydroxyvitamin D with all-cause and cardiovascular disease mortality among individuals incardiovascular-kidney-metabolic syndrome stages 0-3: a cohort study from the NHANES 2001-2018.Diabetology & metabolic syndrome · 2026Article
- The association between life's crucial 9 and osteoarthritis in US adults: the mediating role of central adiposity.Nutrition & metabolism · 2026Article
- Nonlinear associations between serum vitamin mixtures and cardiovascular disease risk: insights from a national cross-sectional analysis.European journal of medical research · 2026Article
- The synergistic impact of anti-inflammatory and nutrient-rich dietary patterns on long-term prognosis among individuals with osteoarthritis.Archives of medical science : AMS · 2026Article
- Temporal trend of serum vitamin profiles and the association with non-alcoholic fatty liver disease.Frontiers in nutrition · 2026Article
- Assessing the Association of the Dietary Inflammatory Index With Stroke Risk and All-Cause Mortality Among Hypertension Patients: A NHANES Cross-Sectional Study (2005-2018).Journal of central nervous system disease · 2026Article
- Nonlinear Association of Daily Sitting Time With Depression Risk in US Adults: A Cross-Sectional Study.Behavioural neurology · 2026Article
- Exploring the impact of dietary theobromine on endometriosis risk: Evidence from Mendelian randomization and NHANES data.Medicine · 2025Observational
- Socioeconomic status, depressive symptoms and cardiometabolic kidney syndrome: an analysis based on national representative data.BMC public health · 2025Article
- Association between neutrophil-lymphocyte ratio and all-cause and cardiovascular mortality in osteoarthritis patients from the NHANES 1999-2018 cohort.Scientific reports · 2025Article
15 more citing papers are in PubMed but not listed here.
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Authors and funding
8 authors at 3 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundThe relationship between vitamin D status and mortality in patients with osteoarthritis (OA) is unknown. This study investigated the associations of serum 25-hydroxyvitamin D [25(OH)D] concentrations with all-cause and cause-specific mortality among American adults with OA.
methodsThis study included 2556 adults with OA from the National Health and Nutrition Examination Survey (2001-2014). Death outcomes were ascertained by linkage to National Death Index (NDI) records through 31 December 2015. Cox proportional hazards model and two-piecewise Cox proportional hazards model were used to elucidate the nonlinear relationship between serum 25(OH)D concentrations and mortality in OA patients, and stratified analyses were performed to identify patients with higher mortality risk.
resultsDuring 16,606 person-years of follow-up, 438 all-cause deaths occurred, including 74 cardiovascular disease (CVD)-related and 78 cancer deaths. After multivariable adjustment, lower serum 25(OH)D levels were significantly and nonlinearly associated with higher risks of all-cause and CVD mortality among participants with OA. Furthermore, we discovered L-shaped associations between serum 25(OH)D levels and all-cause and CVD mortality, with mortality plateauing at 54.40 nmol/L for all-cause mortality and 27.70 nmol/L for CVD mortality. Compared to participants with 25(OH)D levels below the inflection points, those with higher levels had a 2% lower risk for all-cause mortality (hazard ratio [HR] 0.98, 95% confidence interval [CI] 0.96-0.99) and 17% lower risk for CVD mortality (HR 0.83, 95% CI 0.72-0.95).
conclusionsNonlinear associations of serum 25(OH)D levels with all-cause and CVD mortality were observed in American patients with OA. The thresholds of 27.70 and 54.40 nmol/L for CVD and all-cause mortality, respectively, may represent intervention targets for lowering the risk of premature death and cardiovascular disease, but this needs to be confirmed in large clinical trials.
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