Evidence map›Paper›PMID 36127656›Full record

ArticleBMC neurology2022

Kynurenine and oxidative stress in children having learning disorder with and without attention deficit hyperactivity disorder: possible role and involvement.

Ayman Kilany, Neveen Hassan Nashaat, Hala M Zeidan, Adel F Hashish, Mostafa M El-Saied, Ehab Ragaa Abdelraouf

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in BMC neurology, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
7citing papers in PubMed, 1 pooled it
0.5field-weighted citation impact, top 49% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

7 citing papers in PubMed, 1 synthesis or guideline pooled it, 7 citations in OpenAlex.

  1. Pooled it
  2. Article
  3. Serotonin dysfunction in ADHD.Journal of neurodevelopmental disorders · 2025
    Review
  4. Article
  5. Review
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 1 institution in 1 country.

Ayman KilanyMedical Research and Clinical Studies Institute, Children with Special Needs Research Department, National Research Centre, Elbuhouth Street, Cairo, 12622, Dokki, Egypt.ORCID http://orcid.org/0000-0002-3157-8396
Neveen Hassan NashaatMedical Research and Clinical Studies Institute, Children with Special Needs Research Department, National Research Centre, Elbuhouth Street, Cairo, 12622, Dokki, Egypt. dr.neveennashaat@gmail.com.ORCID http://orcid.org/0000-0003-1553-9327
Hala M ZeidanMedical Research and Clinical Studies Institute, Children with Special Needs Research Department, National Research Centre, Elbuhouth Street, Cairo, 12622, Dokki, Egypt.ORCID http://orcid.org/0000-0001-7631-9286
Adel F HashishMedical Research and Clinical Studies Institute, Children with Special Needs Research Department, National Research Centre, Elbuhouth Street, Cairo, 12622, Dokki, Egypt.ORCID http://orcid.org/0000-0001-9549-2973
Mostafa M El-SaiedMedical Research and Clinical Studies Institute, Children with Special Needs Research Department, National Research Centre, Elbuhouth Street, Cairo, 12622, Dokki, Egypt.ORCID http://orcid.org/0000-0002-4809-4435
Ehab Ragaa AbdelraoufMedical Research and Clinical Studies Institute, Children with Special Needs Research Department, National Research Centre, Elbuhouth Street, Cairo, 12622, Dokki, Egypt.ORCID http://orcid.org/0000-0002-0899-8261
National Research Centre · EG

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundThe etiological and pathophysiological factors of learning disorder (LD) and attention deficit hyperactivity disorder (ADHD) are currently not well understood. These disorders disrupt some cognitive abilities. Identifying biomarkers for these disorders is a cornerstone to their proper management. Kynurenine (KYN) and oxidative stress markers have been reported to influence some cognitive abilities. Therefore, the aim was to measure the level of KYN and some oxidative stress indicators in children with LD with and without ADHD and to investigate their correlations with the abilities of children with LD.

methodsThe study included 154 participants who were divided into 3 groups: one for children who have LD (N = 69); another for children with LD and ADHD (N = 31); and a group for neurotypical (NT) children (N = 54). IQ testing, reading, writing, and other ability performance evaluation was performed for children with LD. Measuring plasma levels of KYN, malondialdehyde, glutathione peroxidase, and superoxide dismutase by enzyme-linked immunosorbent assay was performed for all participants.

resultsSome IQ measures and learning skills differed between the first two groups. The biochemical measures differed between children with LD (with and without ADHD) and NT children (p < 0.001). However, the biochemical measures did not show a significant statistical difference between the first two groups. KYN and glutathione peroxidase levels were correlated with one-minute writing and at-risk quotient, respectively (p = 0.03;0.04). KYN and malondialdehyde showed the highest sensitivity and specificity values.

conclusionThese biochemical measures could be involved or have a role in the abilities' performance of children with specific learning disorder.

Indexed as

Attention Deficit Disorder with HyperactivityLearning DisabilitiesChildGlutathione PeroxidaseHumansKynurenineMalondialdehydeOxidative StressSuperoxide DismutaseGlutathione PeroxidaseKynurenineMalondialdehydeSuperoxide DismutaseADHDCognitive abilitiesKynurenineLearning disorderOxidative stress

Identifiers

PMID36127656
PMCPMC9487051
OpenAlexW4296785471

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.